Expression of cholesterol-7α-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL

Expression of cholesterol-7α-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL

Unlike macrophages, the hepatic parenchymal cells express cholesterol-7α-hydroxylase (CYP7A1) which regulates the conversion of cholesterol into bile acids, the major quantitative pathway maintaining cholesterol homeostasis. We examined if CYP7A1 expression in RAW 264.7 macrophages could prevent the...

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Bibliographic Details
Main Authors: Gina L. Moore, Roger A. Davis
Format: Article
Language:English
Published: Elsevier 2002-04-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
bile acids
cholesterol-7 α-hydroxylase
lipoproteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520314930

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