Decreasing susceptibility of bacteria to ampicillin/ sulbactam and third generation cephalosporins in urinary tract infections
Abstract. Background:. Urinary tract infections (UTIs) are among the most common bacterial infections worldwide and have become more difficult to treat over the years. Inappropriate antibiotic use has led to increased antibiotic resistance. Materials and methods:. We examined 1921 urine culture samp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health
2022-06-01
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| Series: | Current Urology |
| Online Access: | http://journals.lww.com/10.1097/CU9.0000000000000079 |
| _version_ | 1797976942007287808 |
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| author | Stefan Vallo Patrick Wirth Adnan Kukic Omar Nafez Ladislau Neagoe Sebastian Nestler Jon Jones |
| author_facet | Stefan Vallo Patrick Wirth Adnan Kukic Omar Nafez Ladislau Neagoe Sebastian Nestler Jon Jones |
| author_sort | Stefan Vallo |
| collection | DOAJ |
| description | Abstract. Background:. Urinary tract infections (UTIs) are among the most common bacterial infections worldwide and have become more difficult to treat over the years. Inappropriate antibiotic use has led to increased antibiotic resistance.
Materials and methods:. We examined 1921 urine culture samples from a single hospital and analyzed them for bacterial spectrum and antibiotic susceptibility. We further analyzed changes in the rates of detected bacteria and of the sensitivity of these uropathogens to antibiotics over the years.
Results:. In our hospital-based analysis, cystitis was the most frequently diagnosed UTI in women (76%) and men (79%). Escherichia coli (48%) was the most commonly identified uropathogen. Samples demonstrated an increase in the proportion of E. coli (p < 0.001) and a decrease in Enterococcus faecalis (p < 0.001) over the study time period. Antimicrobial susceptibility analysis showed an increase over time in the number of isolates with resistance to ampicillin/sulbactam (p < 0.001) and to third-generation cephalosporins cefotaxime (p = 0.043) and ceftazidime (p < 0.001).
Conclusions:. Ampicillin/sulbactam and third-generation cephalosporins are antibiotics frequently used in the treatment of UTIs. When selecting an optimal antimicrobial treatment regimen for patients with UTIs, it is imperative to understand regional and timedependent differences in the prevalence of various uropathogens and antimicrobial resistance patterns. Therefore, continuous surveillance of local pathogen and antimicrobial susceptibility patterns for frequently used antibiotics should be prioritized. |
| first_indexed | 2024-04-11T04:59:02Z |
| format | Article |
| id | doaj.art-a49c0405f72c450cbe072eb5998caae1 |
| institution | Directory Open Access Journal |
| issn | 1661-7649 1661-7657 |
| language | English |
| last_indexed | 2024-04-11T04:59:02Z |
| publishDate | 2022-06-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Current Urology |
| spelling | doaj.art-a49c0405f72c450cbe072eb5998caae12022-12-26T06:01:49ZengWolters Kluwer HealthCurrent Urology1661-76491661-76572022-06-01162949810.1097/CU9.0000000000000079202206000-00009Decreasing susceptibility of bacteria to ampicillin/ sulbactam and third generation cephalosporins in urinary tract infectionsStefan ValloPatrick WirthAdnan KukicOmar NafezLadislau NeagoeSebastian NestlerJon JonesAbstract. Background:. Urinary tract infections (UTIs) are among the most common bacterial infections worldwide and have become more difficult to treat over the years. Inappropriate antibiotic use has led to increased antibiotic resistance. Materials and methods:. We examined 1921 urine culture samples from a single hospital and analyzed them for bacterial spectrum and antibiotic susceptibility. We further analyzed changes in the rates of detected bacteria and of the sensitivity of these uropathogens to antibiotics over the years. Results:. In our hospital-based analysis, cystitis was the most frequently diagnosed UTI in women (76%) and men (79%). Escherichia coli (48%) was the most commonly identified uropathogen. Samples demonstrated an increase in the proportion of E. coli (p < 0.001) and a decrease in Enterococcus faecalis (p < 0.001) over the study time period. Antimicrobial susceptibility analysis showed an increase over time in the number of isolates with resistance to ampicillin/sulbactam (p < 0.001) and to third-generation cephalosporins cefotaxime (p = 0.043) and ceftazidime (p < 0.001). Conclusions:. Ampicillin/sulbactam and third-generation cephalosporins are antibiotics frequently used in the treatment of UTIs. When selecting an optimal antimicrobial treatment regimen for patients with UTIs, it is imperative to understand regional and timedependent differences in the prevalence of various uropathogens and antimicrobial resistance patterns. Therefore, continuous surveillance of local pathogen and antimicrobial susceptibility patterns for frequently used antibiotics should be prioritized.http://journals.lww.com/10.1097/CU9.0000000000000079 |
| spellingShingle | Stefan Vallo Patrick Wirth Adnan Kukic Omar Nafez Ladislau Neagoe Sebastian Nestler Jon Jones Decreasing susceptibility of bacteria to ampicillin/ sulbactam and third generation cephalosporins in urinary tract infections Current Urology |
| title | Decreasing susceptibility of bacteria to ampicillin/ sulbactam and third generation cephalosporins in urinary tract infections |
| title_full | Decreasing susceptibility of bacteria to ampicillin/ sulbactam and third generation cephalosporins in urinary tract infections |
| title_fullStr | Decreasing susceptibility of bacteria to ampicillin/ sulbactam and third generation cephalosporins in urinary tract infections |
| title_full_unstemmed | Decreasing susceptibility of bacteria to ampicillin/ sulbactam and third generation cephalosporins in urinary tract infections |
| title_short | Decreasing susceptibility of bacteria to ampicillin/ sulbactam and third generation cephalosporins in urinary tract infections |
| title_sort | decreasing susceptibility of bacteria to ampicillin sulbactam and third generation cephalosporins in urinary tract infections |
| url | http://journals.lww.com/10.1097/CU9.0000000000000079 |
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