Recurrent nuclear protein of the testis carcinoma of the submandibular gland treated with multimodality therapy: A case report and review of the literature
Background: Nuclear protein of the testis (NUT) carcinoma (NC) is a rare type of poorly differentiated carcinoma. The median overall survival is 6.7–9.5 months. Surgery and radiotherapy are the main modalities of treatment. The efficacy of chemotherapy is often overlooked. Case report: A 7-year-old...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Pediatric Hematology Oncology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S246812452300013X |
| _version_ | 1797790073176981504 |
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| author | Kaixin Guo Chenggong Zeng Hongyu Jiang Wenhao Luo Zijun Zhen Yujie Liang |
| author_facet | Kaixin Guo Chenggong Zeng Hongyu Jiang Wenhao Luo Zijun Zhen Yujie Liang |
| author_sort | Kaixin Guo |
| collection | DOAJ |
| description | Background: Nuclear protein of the testis (NUT) carcinoma (NC) is a rare type of poorly differentiated carcinoma. The median overall survival is 6.7–9.5 months. Surgery and radiotherapy are the main modalities of treatment. The efficacy of chemotherapy is often overlooked. Case report: A 7-year-old pediatric patient was diagnosed with recurrent NC of the submandibular gland, an uncommon site of NC. The tumor split and contracted following chemotherapy with cyclophosphamide, pirarubicin, cisplatin, ifosfamide, and etoposide. Subsequently, surgery was performed to excise the tumor with negative margins. Three months after the end of the multimodality treatment, the imaging did not show signs of recurrence or metastasis. Conclusion: The chemotherapy regimen of cyclophosphamide, pirarubicin, cisplatin, ifosfamide, and etoposide may be a new attempt to treat NC. |
| first_indexed | 2024-03-13T01:59:33Z |
| format | Article |
| id | doaj.art-a49d3c2502374fd9b1d8c7c6d2a52bf1 |
| institution | Directory Open Access Journal |
| issn | 2468-1245 |
| language | English |
| last_indexed | 2024-03-13T01:59:33Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatric Hematology Oncology Journal |
| spelling | doaj.art-a49d3c2502374fd9b1d8c7c6d2a52bf12023-07-02T04:17:02ZengElsevierPediatric Hematology Oncology Journal2468-12452023-06-01828589Recurrent nuclear protein of the testis carcinoma of the submandibular gland treated with multimodality therapy: A case report and review of the literatureKaixin Guo0Chenggong Zeng1Hongyu Jiang2Wenhao Luo3Zijun Zhen4Yujie Liang5Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, ChinaDepartment of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, ChinaDepartment of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, ChinaDepartment of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, ChinaDepartment of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China; Corresponding author. Department of Pediatric Oncology, Sun Yat-sen University Cancer Center, 651th Dongfengdong Road, Guangzhou, Guangdong, 510060, China.Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, China; Corresponding author. Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, 56th Lingyuanxi Road, Guangzhou, Guangdong, 510055, China.Background: Nuclear protein of the testis (NUT) carcinoma (NC) is a rare type of poorly differentiated carcinoma. The median overall survival is 6.7–9.5 months. Surgery and radiotherapy are the main modalities of treatment. The efficacy of chemotherapy is often overlooked. Case report: A 7-year-old pediatric patient was diagnosed with recurrent NC of the submandibular gland, an uncommon site of NC. The tumor split and contracted following chemotherapy with cyclophosphamide, pirarubicin, cisplatin, ifosfamide, and etoposide. Subsequently, surgery was performed to excise the tumor with negative margins. Three months after the end of the multimodality treatment, the imaging did not show signs of recurrence or metastasis. Conclusion: The chemotherapy regimen of cyclophosphamide, pirarubicin, cisplatin, ifosfamide, and etoposide may be a new attempt to treat NC.http://www.sciencedirect.com/science/article/pii/S246812452300013XNUT CarcinomaMultimodality therapyNUTM1-BRD4Submandibular gland |
| spellingShingle | Kaixin Guo Chenggong Zeng Hongyu Jiang Wenhao Luo Zijun Zhen Yujie Liang Recurrent nuclear protein of the testis carcinoma of the submandibular gland treated with multimodality therapy: A case report and review of the literature Pediatric Hematology Oncology Journal NUT Carcinoma Multimodality therapy NUTM1-BRD4 Submandibular gland |
| title | Recurrent nuclear protein of the testis carcinoma of the submandibular gland treated with multimodality therapy: A case report and review of the literature |
| title_full | Recurrent nuclear protein of the testis carcinoma of the submandibular gland treated with multimodality therapy: A case report and review of the literature |
| title_fullStr | Recurrent nuclear protein of the testis carcinoma of the submandibular gland treated with multimodality therapy: A case report and review of the literature |
| title_full_unstemmed | Recurrent nuclear protein of the testis carcinoma of the submandibular gland treated with multimodality therapy: A case report and review of the literature |
| title_short | Recurrent nuclear protein of the testis carcinoma of the submandibular gland treated with multimodality therapy: A case report and review of the literature |
| title_sort | recurrent nuclear protein of the testis carcinoma of the submandibular gland treated with multimodality therapy a case report and review of the literature |
| topic | NUT Carcinoma Multimodality therapy NUTM1-BRD4 Submandibular gland |
| url | http://www.sciencedirect.com/science/article/pii/S246812452300013X |
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