Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation
Cancer is one of the deadliest non communicable diseases. Numerous anticancer medications have been developed to target the molecular pathways driving cancer. However, there has been no discernible increase in the overall survival rate in cancer patients. Therefore, innovative chemo-preventive techn...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/24/15765 |
| _version_ | 1797457279213109248 |
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| author | Muhammad Bilal Ahmed Salman Ul Islam Abdullah A. A. Alghamdi Muhammad Kamran Haseeb Ahsan Young Sup Lee |
| author_facet | Muhammad Bilal Ahmed Salman Ul Islam Abdullah A. A. Alghamdi Muhammad Kamran Haseeb Ahsan Young Sup Lee |
| author_sort | Muhammad Bilal Ahmed |
| collection | DOAJ |
| description | Cancer is one of the deadliest non communicable diseases. Numerous anticancer medications have been developed to target the molecular pathways driving cancer. However, there has been no discernible increase in the overall survival rate in cancer patients. Therefore, innovative chemo-preventive techniques and agents are required to supplement standard cancer treatments and boost their efficacy. Fruits and vegetables should be tapped into as a source of compounds that can serve as cancer therapy. Phytochemicals play an important role as sources of new medication in cancer treatment. Some synthetic and natural chemicals are effective for cancer chemoprevention, i.e., the use of exogenous medicine to inhibit or impede tumor development. They help regulate molecular pathways linked to the development and spread of cancer. They can enhance antioxidant status, inactivating carcinogens, suppressing proliferation, inducing cell cycle arrest and death, and regulating the immune system. While focusing on four main categories of plant-based anticancer agents, i.e., epipodophyllotoxin, camptothecin derivatives, taxane diterpenoids, and vinca alkaloids and their mode of action, we review the anticancer effects of phytochemicals, like quercetin, curcumin, piperine, epigallocatechin gallate (EGCG), and gingerol. We examine the different signaling pathways associated with cancer and how inflammation as a key mechanism is linked to cancer growth. |
| first_indexed | 2024-03-09T16:19:56Z |
| format | Article |
| id | doaj.art-a49dc7f610aa4ee08707ec691be3d817 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:19:56Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a49dc7f610aa4ee08707ec691be3d8172023-11-24T15:27:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241576510.3390/ijms232415765Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and InflammationMuhammad Bilal Ahmed0Salman Ul Islam1Abdullah A. A. Alghamdi2Muhammad Kamran3Haseeb Ahsan4Young Sup Lee5BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu 41566, Republic of KoreaDepartment of Pharmacy, Cecos University, Peshawar, Street 1, Sector F 5 Phase 6 Hayatabad, Peshawar 25000, PakistanDepartment of Biology, Faculty of Science, Albaha University, Albaha 65527, Saudi ArabiaSchool of Molecular Sciences, The University of Western Australia, M310, 35 Stirling Hwy, Perth, WA 6009, AustraliaDepartment of Pharmacy, Faculty of Life and Environmental Sciences, University of Peshawar, Peshawar 25120, PakistanBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu 41566, Republic of KoreaCancer is one of the deadliest non communicable diseases. Numerous anticancer medications have been developed to target the molecular pathways driving cancer. However, there has been no discernible increase in the overall survival rate in cancer patients. Therefore, innovative chemo-preventive techniques and agents are required to supplement standard cancer treatments and boost their efficacy. Fruits and vegetables should be tapped into as a source of compounds that can serve as cancer therapy. Phytochemicals play an important role as sources of new medication in cancer treatment. Some synthetic and natural chemicals are effective for cancer chemoprevention, i.e., the use of exogenous medicine to inhibit or impede tumor development. They help regulate molecular pathways linked to the development and spread of cancer. They can enhance antioxidant status, inactivating carcinogens, suppressing proliferation, inducing cell cycle arrest and death, and regulating the immune system. While focusing on four main categories of plant-based anticancer agents, i.e., epipodophyllotoxin, camptothecin derivatives, taxane diterpenoids, and vinca alkaloids and their mode of action, we review the anticancer effects of phytochemicals, like quercetin, curcumin, piperine, epigallocatechin gallate (EGCG), and gingerol. We examine the different signaling pathways associated with cancer and how inflammation as a key mechanism is linked to cancer growth.https://www.mdpi.com/1422-0067/23/24/15765phytochemicalschemopreventioncancersignaling pathwayscell cycleapoptosis |
| spellingShingle | Muhammad Bilal Ahmed Salman Ul Islam Abdullah A. A. Alghamdi Muhammad Kamran Haseeb Ahsan Young Sup Lee Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation International Journal of Molecular Sciences phytochemicals chemoprevention cancer signaling pathways cell cycle apoptosis |
| title | Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation |
| title_full | Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation |
| title_fullStr | Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation |
| title_full_unstemmed | Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation |
| title_short | Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation |
| title_sort | phytochemicals as chemo preventive agents and signaling molecule modulators current role in cancer therapeutics and inflammation |
| topic | phytochemicals chemoprevention cancer signaling pathways cell cycle apoptosis |
| url | https://www.mdpi.com/1422-0067/23/24/15765 |
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