Expression of Human ACE2 N-terminal Domain, Part of the Receptor for SARS-CoV-2, in Fusion With Maltose-Binding Protein, E. coli Ribonuclease I and Human RNase A

Expression of Human ACE2 N-terminal Domain, Part of the Receptor for SARS-CoV-2, in Fusion With Maltose-Binding Protein, E. coli Ribonuclease I and Human RNase A

The SARS-CoV-2 viral genome contains a positive-strand single-stranded RNA of ∼30 kb. Human ACE2 protein is the receptor for SARS-CoV-2 virus attachment and infection. We propose to use ribonucleases (RNases) as antiviral agents to destroy the viral genome in vitro. In the virions, the RNA is protec...

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Bibliographic Details
Main Authors: Shuang-yong Xu, Alexey Fomenkov, Tien-Hao Chen, Erbay Yigit
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Microbiology
Subjects:
E. coli ribonuclease I (RNase I)
RNase III
RNase I-ACE2NTD fusion
human RNase A-ACE2NTD fusion
SARS-CoV-2
human ACE2 receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.660149/full

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