Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate
Abstract Background White Portland cement is a calcium silicate material. It exhibits antibacterial properties and is biocompatible. In addition, calcium silicate-based materials are known to release calcium ions and form apatite. The purpose of this study was to develop a novel bioactive restorativ...
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| 格式: | 文件 |
| 语言: | English |
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American Association for the Advancement of Science (AAAS)
2023-03-01
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| 丛编: | Biomaterials Research |
| 主题: | |
| 在线阅读: | https://doi.org/10.1186/s40824-023-00364-z |
| _version_ | 1827331204651679744 |
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| author | Song-Yi Yang A Ruem Han Ji-Won Choi Kwang-Mahn Kim Jae-Sung Kwon |
| author_facet | Song-Yi Yang A Ruem Han Ji-Won Choi Kwang-Mahn Kim Jae-Sung Kwon |
| author_sort | Song-Yi Yang |
| collection | DOAJ |
| description | Abstract Background White Portland cement is a calcium silicate material. It exhibits antibacterial properties and is biocompatible. In addition, calcium silicate-based materials are known to release calcium ions and form apatite. The purpose of this study was to develop a novel bioactive restorative resin composite with antibacterial and apatite forming properties to prevent tooth caries at the interface of teeth and restorative materials, by incorporation of hydrated calcium silicate (hCS) derived from white Portland cement. Methods To prepare the experimental composite resins, a 30 wt% light-curable resin matrix and 70 wt% filler, which was mixed with hCS and silanized glass powder were prepared in following concentrations: 0, 17.5, 35.0, and 52.5 wt% hCS filler. The depth of cure, flexural strength, water sorption, solubility, and antibacterial effect were tested. After immersion in artificial saliva solution for 15, 30, 60, and 90 days, ion concentration by ICP-MS and apatite formation using SEM-EDS, Raman spectroscopy and XRD from experimental specimens were analyzed. Results All experimental groups showed clinically acceptable depths of cure and flexural strength for the use as the restorative composite resin. Water sorption, solubility, released Ca and Si ions increased with the addition of hCS to the experimental composite resin. Experimental groups containing hCS showed greater antibacterial effects compared with the 0 wt% hCS filler group (p < 0.05). The 52.5 wt% hCS filler group produced precipitates mainly composed of Ca and P detected as hydroxyapatite after immersion in artificial saliva solution for 30, 60, and 90 days. Conclusions This results show that composite resins containing hCS filler is effective in antibacterial effects. hCS has also apatite formation ability for reducing gap size of microleakage by accumulating hydroxyapatite precipitates at the restoration-tooth interface. Therefore, novel composite resin containing hCS is promising bioactive resin because of its clinically acceptable physiochemical properties, antibacterial properties, and self-sealing potential for prevention of microleakage for longer usage of restorations. |
| first_indexed | 2024-03-07T16:30:43Z |
| format | Article |
| id | doaj.art-a49fbc43ec514621a5a901b3f976ea49 |
| institution | Directory Open Access Journal |
| issn | 2055-7124 |
| language | English |
| last_indexed | 2024-03-07T16:30:43Z |
| publishDate | 2023-03-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Biomaterials Research |
| spelling | doaj.art-a49fbc43ec514621a5a901b3f976ea492024-03-03T11:11:11ZengAmerican Association for the Advancement of Science (AAAS)Biomaterials Research2055-71242023-03-0127111510.1186/s40824-023-00364-zNovel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicateSong-Yi Yang0A Ruem Han1Ji-Won Choi2Kwang-Mahn Kim3Jae-Sung Kwon4Department of Dental Hygiene, Konyang UniversityDepartment and Research Institute of Dental Biomaterials and Bioengineering, BK21 FOUR Project, Yonsei University College of DentistryDepartment and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of DentistryDepartment and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of DentistryDepartment and Research Institute of Dental Biomaterials and Bioengineering, BK21 FOUR Project, Yonsei University College of DentistryAbstract Background White Portland cement is a calcium silicate material. It exhibits antibacterial properties and is biocompatible. In addition, calcium silicate-based materials are known to release calcium ions and form apatite. The purpose of this study was to develop a novel bioactive restorative resin composite with antibacterial and apatite forming properties to prevent tooth caries at the interface of teeth and restorative materials, by incorporation of hydrated calcium silicate (hCS) derived from white Portland cement. Methods To prepare the experimental composite resins, a 30 wt% light-curable resin matrix and 70 wt% filler, which was mixed with hCS and silanized glass powder were prepared in following concentrations: 0, 17.5, 35.0, and 52.5 wt% hCS filler. The depth of cure, flexural strength, water sorption, solubility, and antibacterial effect were tested. After immersion in artificial saliva solution for 15, 30, 60, and 90 days, ion concentration by ICP-MS and apatite formation using SEM-EDS, Raman spectroscopy and XRD from experimental specimens were analyzed. Results All experimental groups showed clinically acceptable depths of cure and flexural strength for the use as the restorative composite resin. Water sorption, solubility, released Ca and Si ions increased with the addition of hCS to the experimental composite resin. Experimental groups containing hCS showed greater antibacterial effects compared with the 0 wt% hCS filler group (p < 0.05). The 52.5 wt% hCS filler group produced precipitates mainly composed of Ca and P detected as hydroxyapatite after immersion in artificial saliva solution for 30, 60, and 90 days. Conclusions This results show that composite resins containing hCS filler is effective in antibacterial effects. hCS has also apatite formation ability for reducing gap size of microleakage by accumulating hydroxyapatite precipitates at the restoration-tooth interface. Therefore, novel composite resin containing hCS is promising bioactive resin because of its clinically acceptable physiochemical properties, antibacterial properties, and self-sealing potential for prevention of microleakage for longer usage of restorations.https://doi.org/10.1186/s40824-023-00364-zRestorative composite resinWhite Portland cementHydrated calcium silicateAntibacterialApatite formation |
| spellingShingle | Song-Yi Yang A Ruem Han Ji-Won Choi Kwang-Mahn Kim Jae-Sung Kwon Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate Biomaterials Research Restorative composite resin White Portland cement Hydrated calcium silicate Antibacterial Apatite formation |
| title | Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate |
| title_full | Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate |
| title_fullStr | Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate |
| title_full_unstemmed | Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate |
| title_short | Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate |
| title_sort | novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate |
| topic | Restorative composite resin White Portland cement Hydrated calcium silicate Antibacterial Apatite formation |
| url | https://doi.org/10.1186/s40824-023-00364-z |
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