O-11 THE PUBLIC HEALTH POLICIES REDUCE THE LONG-TERM BURDEN OF ALCOHOL-ASSOCIATED LIVER DISEASE WORLDWIDE: DEVELOPMENT OF A PREPAREDNESS INDEX
Introduction and Objectives: The long-term impact of alcohol-related public health policies (PHP) on the burden of liver disease is unclear. This study aimed to assess the association between alcohol-related PHP and alcohol-related health consequences; 2. To develop an instrument to quantify the est...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
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| Series: | Annals of Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268123001254 |
| _version_ | 1827981913763086336 |
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| author | Luis Antonio Díaz Eduardo Fuentes-López Francisco Idalsoaga Jorge Arnold Gustavo Ayares Macarena Cannistra Danae Vio Andrea Márquez-Lomas Oscar Corsi Carolina A. Ramírez María Paz Medel Catterina Ferreccio Mariana Lazo Juan Pablo Roblero Thomas Cotter Anand V. Kulkarni Won Kim Mayur Brahmania Alexandre Louvet Elliot Tapper Winston Dunn Douglas Simonetto Vijay Shah Patrick Kamath Jeffrey V. Lazarus Ashwani K. Singal Ramon Bataller Marco Arrese Juan Pablo Arab |
| author_facet | Luis Antonio Díaz Eduardo Fuentes-López Francisco Idalsoaga Jorge Arnold Gustavo Ayares Macarena Cannistra Danae Vio Andrea Márquez-Lomas Oscar Corsi Carolina A. Ramírez María Paz Medel Catterina Ferreccio Mariana Lazo Juan Pablo Roblero Thomas Cotter Anand V. Kulkarni Won Kim Mayur Brahmania Alexandre Louvet Elliot Tapper Winston Dunn Douglas Simonetto Vijay Shah Patrick Kamath Jeffrey V. Lazarus Ashwani K. Singal Ramon Bataller Marco Arrese Juan Pablo Arab |
| author_sort | Luis Antonio Díaz |
| collection | DOAJ |
| description | Introduction and Objectives: The long-term impact of alcohol-related public health policies (PHP) on the burden of liver disease is unclear. This study aimed to assess the association between alcohol-related PHP and alcohol-related health consequences; 2. To develop an instrument to quantify the establishment of alcohol-related PHP in each country. Materials and Methods: We performed an ecological multi-national study including 169 countries. We recorded socio-demographic data and the presence of alcohol-related PHP in each country from the WHO Global Information System of Alcohol and Health (GISAH) in 2010. Data on alcohol-related health consequences was collected from the Global Burden of Disease database (between 2010-2019). We classified the WHO categories into five domains to design an instrument with criteria for a low, moderate, and strong establishment of PHP. We estimated an incidence rate ratio (IRR) using multilevel generalized linear models with a Poisson family distribution. The models were adjusted by population size, age structure, and gross domestic product. We also estimated a preparedness index using multiple correspondence analysis. Results: The table summarizes the final instrument. We included 169 countries; the median preparedness index was 54 [34.9-76.8]. The preparedness index was associated with lower alcohol-associated liver disease (ALD) mortality (IRR:0.25, 95%CI: 0.06-1.09, p=0.064), cancer mortality (IRR:0.22, 95%CI: 0.05-0.97, p=0.046), hepatocellular carcinoma (HCC) mortality (IRR:0.20, 95%CI: 0.04-0.95, p=0.043), and cardiovascular mortality (IRR:0.15, 95%CI: 0.04-0.61, p=0.008). There was also a trend to lower alcohol use disorder prevalence (IRR:0.25, 95%CI: 0.06-1.09, p=0.064). The highest linear associations were observed in the Americas and Africa, while Europe exhibits a nonlinear association. Conclusions: The preparedness index on alcohol policies is a valuable instrument to assess the establishment and strength of PHP. Those countries with a higher number of PHP had lower mortality due to ALD, cancer, HCC, and cardiovascular diseases. Our results strongly encourage the development and implementation of PHP on alcohol consumption worldwide. |
| first_indexed | 2024-04-09T22:15:20Z |
| format | Article |
| id | doaj.art-a4a189594488477e8110f34e665ff514 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-04-09T22:15:20Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-a4a189594488477e8110f34e665ff5142023-03-23T04:34:34ZengElsevierAnnals of Hepatology1665-26812023-03-0128101021O-11 THE PUBLIC HEALTH POLICIES REDUCE THE LONG-TERM BURDEN OF ALCOHOL-ASSOCIATED LIVER DISEASE WORLDWIDE: DEVELOPMENT OF A PREPAREDNESS INDEXLuis Antonio Díaz0Eduardo Fuentes-López1Francisco Idalsoaga2Jorge Arnold3Gustavo Ayares4Macarena Cannistra5Danae Vio6Andrea Márquez-Lomas7Oscar Corsi8Carolina A. Ramírez9María Paz Medel10Catterina Ferreccio11Mariana Lazo12Juan Pablo Roblero13Thomas Cotter14Anand V. Kulkarni15Won Kim16Mayur Brahmania17Alexandre Louvet18Elliot Tapper19Winston Dunn20Douglas Simonetto21Vijay Shah22Patrick Kamath23Jeffrey V. Lazarus24Ashwani K. Singal25Ramon Bataller26Marco Arrese27Juan Pablo Arab28Department of Gastroenterology, School of Medicine, Pontifical Catholic University of Chile, Santiago, ChileDepartment of Health Sciences, School of Medicine Pontifical Catholic University of Chile, Santiago, ChileDepartment of Gastroenterology, School of Medicine, Pontifical Catholic University of Chile, Santiago, ChileDepartment of Gastroenterology, School of Medicine, Pontifical Catholic University of Chile, Santiago, ChileDepartment of Gastroenterology, School of Medicine, Pontifical Catholic University of Chile, Santiago, ChileSchool of Medicine Pontifical Catholic University of Chile, Santiago, ChileSchool of Medicine Pontifical Catholic University of Chile, Santiago, ChileSchool of Medicine, Universidad Anáhuac Mayab, Mérida, MexicoDepartment of Gastroenterology, School of Medicine, Pontifical Catholic University of Chile, Santiago, ChileDepartment of Anesthesiology, Las Condes Clinic, Santiago, ChileDepartment of Family Medicine, School of Medicine, Pontifical Catholic University of Chile, Santiago, ChilePublic Health Department, School of Medicine, Pontifical Catholic University of Chile, Santiago, Chile. Advanced Center for Chronic Diseases, Accdis, Santiago, ChileDepartment of Community Health and Prevention, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania; Urban Health Collaborative, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania; Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MarylandGastroenterology Section, University Clinical Hospital of Chile, School of Medicine. University of Chile, Santiago, ChileDivision of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USADepartment of Hepatology, Asian Institute of Gastroenterology, Hyderabad, IndiaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, KoreaDivision of Gastroenterology, Department of Medicine, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, CanadaClaude Huriez Hospital, Services des Maladies de L'appareil Digestif, Chru Lille, and Unité Inserm 995, Lille, FranceDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan; Gastroenterology Section, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, USAUniversity of Kansas Medical Center, KS, USADivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USADivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USADivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USABarcelona Institute for Global Health (ISGLOBAL), Hospital Clinic, University of Barcelona, Barcelona, SpainDepartment of Medicine, University of South Dakota Sanford School of Medicine, Division of Transplant Hepatology, Avera Transplant Institute, Sioux Falls, SD, United StatesCenter for Liver Diseases, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, PA, USADepartment of Gastroenterology, School of Medicine, Pontifical Catholic University of Chile, Santiago, ChileDepartment of Gastroenterology, School of Medicine, Pontifical Catholic University of Chile, Santiago, Chile; Division of Gastroenterology, Department of Medicine, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, Canada; Alimentiv, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine, Western University, London, Ontario, CanadaIntroduction and Objectives: The long-term impact of alcohol-related public health policies (PHP) on the burden of liver disease is unclear. This study aimed to assess the association between alcohol-related PHP and alcohol-related health consequences; 2. To develop an instrument to quantify the establishment of alcohol-related PHP in each country. Materials and Methods: We performed an ecological multi-national study including 169 countries. We recorded socio-demographic data and the presence of alcohol-related PHP in each country from the WHO Global Information System of Alcohol and Health (GISAH) in 2010. Data on alcohol-related health consequences was collected from the Global Burden of Disease database (between 2010-2019). We classified the WHO categories into five domains to design an instrument with criteria for a low, moderate, and strong establishment of PHP. We estimated an incidence rate ratio (IRR) using multilevel generalized linear models with a Poisson family distribution. The models were adjusted by population size, age structure, and gross domestic product. We also estimated a preparedness index using multiple correspondence analysis. Results: The table summarizes the final instrument. We included 169 countries; the median preparedness index was 54 [34.9-76.8]. The preparedness index was associated with lower alcohol-associated liver disease (ALD) mortality (IRR:0.25, 95%CI: 0.06-1.09, p=0.064), cancer mortality (IRR:0.22, 95%CI: 0.05-0.97, p=0.046), hepatocellular carcinoma (HCC) mortality (IRR:0.20, 95%CI: 0.04-0.95, p=0.043), and cardiovascular mortality (IRR:0.15, 95%CI: 0.04-0.61, p=0.008). There was also a trend to lower alcohol use disorder prevalence (IRR:0.25, 95%CI: 0.06-1.09, p=0.064). The highest linear associations were observed in the Americas and Africa, while Europe exhibits a nonlinear association. Conclusions: The preparedness index on alcohol policies is a valuable instrument to assess the establishment and strength of PHP. Those countries with a higher number of PHP had lower mortality due to ALD, cancer, HCC, and cardiovascular diseases. Our results strongly encourage the development and implementation of PHP on alcohol consumption worldwide.http://www.sciencedirect.com/science/article/pii/S1665268123001254 |
| spellingShingle | Luis Antonio Díaz Eduardo Fuentes-López Francisco Idalsoaga Jorge Arnold Gustavo Ayares Macarena Cannistra Danae Vio Andrea Márquez-Lomas Oscar Corsi Carolina A. Ramírez María Paz Medel Catterina Ferreccio Mariana Lazo Juan Pablo Roblero Thomas Cotter Anand V. Kulkarni Won Kim Mayur Brahmania Alexandre Louvet Elliot Tapper Winston Dunn Douglas Simonetto Vijay Shah Patrick Kamath Jeffrey V. Lazarus Ashwani K. Singal Ramon Bataller Marco Arrese Juan Pablo Arab O-11 THE PUBLIC HEALTH POLICIES REDUCE THE LONG-TERM BURDEN OF ALCOHOL-ASSOCIATED LIVER DISEASE WORLDWIDE: DEVELOPMENT OF A PREPAREDNESS INDEX Annals of Hepatology |
| title | O-11 THE PUBLIC HEALTH POLICIES REDUCE THE LONG-TERM BURDEN OF ALCOHOL-ASSOCIATED LIVER DISEASE WORLDWIDE: DEVELOPMENT OF A PREPAREDNESS INDEX |
| title_full | O-11 THE PUBLIC HEALTH POLICIES REDUCE THE LONG-TERM BURDEN OF ALCOHOL-ASSOCIATED LIVER DISEASE WORLDWIDE: DEVELOPMENT OF A PREPAREDNESS INDEX |
| title_fullStr | O-11 THE PUBLIC HEALTH POLICIES REDUCE THE LONG-TERM BURDEN OF ALCOHOL-ASSOCIATED LIVER DISEASE WORLDWIDE: DEVELOPMENT OF A PREPAREDNESS INDEX |
| title_full_unstemmed | O-11 THE PUBLIC HEALTH POLICIES REDUCE THE LONG-TERM BURDEN OF ALCOHOL-ASSOCIATED LIVER DISEASE WORLDWIDE: DEVELOPMENT OF A PREPAREDNESS INDEX |
| title_short | O-11 THE PUBLIC HEALTH POLICIES REDUCE THE LONG-TERM BURDEN OF ALCOHOL-ASSOCIATED LIVER DISEASE WORLDWIDE: DEVELOPMENT OF A PREPAREDNESS INDEX |
| title_sort | o 11 the public health policies reduce the long term burden of alcohol associated liver disease worldwide development of a preparedness index |
| url | http://www.sciencedirect.com/science/article/pii/S1665268123001254 |
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