High-Content RNAi Phenotypic Screening Unveils the Involvement of Human Ubiquitin-Related Enzymes in Late Cytokinesis

High-Content RNAi Phenotypic Screening Unveils the Involvement of Human Ubiquitin-Related Enzymes in Late Cytokinesis

CEP55 is a central regulator of late cytokinesis and is overexpressed in numerous cancers. Its post-translationally controlled recruitment to the midbody is crucial to the structural coordination of the abscission sequence. Our recent evidence that CEP55 contains two ubiquitin-binding domains was th...

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Bibliographic Details
Main Authors: Mikaël Boullé, Laurianne Davignon, Keïs Nabhane Saïd Halidi, Salomé Guez, Emilie Giraud, Marcel Hollenstein, Fabrice Agou
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
cytokinesis
CEP55
ubiquitin signaling
RNAi
image analysis tool
high-content screening
Online Access:https://www.mdpi.com/2073-4409/11/23/3862

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