Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke
The use of a developed experimental model of a natural fire made it possible to assess the consequences of 24 h exposure to peat combustion products in albino rats. Peat smoke exposure leads to behavioral disturbances in rats, characterized by an increase in locomotor activity and an increased level...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/9/12/342 |
| _version_ | 1797500249757974528 |
|---|---|
| author | Vera A. Vokina Larisa M. Sosedova Mikhail A. Novikov Viktor S. Rukavishnikov Ekaterina A. Kapustina Anton N. Alekseenko Elizaveta S. Andreeva |
| author_facet | Vera A. Vokina Larisa M. Sosedova Mikhail A. Novikov Viktor S. Rukavishnikov Ekaterina A. Kapustina Anton N. Alekseenko Elizaveta S. Andreeva |
| author_sort | Vera A. Vokina |
| collection | DOAJ |
| description | The use of a developed experimental model of a natural fire made it possible to assess the consequences of 24 h exposure to peat combustion products in albino rats. Peat smoke exposure leads to behavioral disturbances in rats, characterized by an increase in locomotor activity and an increased level of anxiety. Indicators of brain bioelectrical activity of the exposed animals supported the state of anxiety and psychoemotional stress. Epigenetic changes in the blood cells of exposed animals were revealed under 24 h exposure to peat smoke, characterized by a decrease in the level of global DNA methylation. |
| first_indexed | 2024-03-10T03:59:12Z |
| format | Article |
| id | doaj.art-a4a43c16f2bd4f608f047aa740b085f5 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T03:59:12Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-a4a43c16f2bd4f608f047aa740b085f52023-11-23T10:49:53ZengMDPI AGToxics2305-63042021-12-0191234210.3390/toxics9120342Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat SmokeVera A. Vokina0Larisa M. Sosedova1Mikhail A. Novikov2Viktor S. Rukavishnikov3Ekaterina A. Kapustina4Anton N. Alekseenko5Elizaveta S. Andreeva6FSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, RussiaFSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, RussiaFSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, RussiaFSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, RussiaFSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, RussiaFSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, RussiaFSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, RussiaThe use of a developed experimental model of a natural fire made it possible to assess the consequences of 24 h exposure to peat combustion products in albino rats. Peat smoke exposure leads to behavioral disturbances in rats, characterized by an increase in locomotor activity and an increased level of anxiety. Indicators of brain bioelectrical activity of the exposed animals supported the state of anxiety and psychoemotional stress. Epigenetic changes in the blood cells of exposed animals were revealed under 24 h exposure to peat smoke, characterized by a decrease in the level of global DNA methylation.https://www.mdpi.com/2305-6304/9/12/342peat smokeratsEEGbehaviorDNA fragmentation and methylation |
| spellingShingle | Vera A. Vokina Larisa M. Sosedova Mikhail A. Novikov Viktor S. Rukavishnikov Ekaterina A. Kapustina Anton N. Alekseenko Elizaveta S. Andreeva Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke Toxics peat smoke rats EEG behavior DNA fragmentation and methylation |
| title | Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke |
| title_full | Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke |
| title_fullStr | Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke |
| title_full_unstemmed | Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke |
| title_short | Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke |
| title_sort | alterations in cns functions and dna methylation in rats after 24 h exposure to peat smoke |
| topic | peat smoke rats EEG behavior DNA fragmentation and methylation |
| url | https://www.mdpi.com/2305-6304/9/12/342 |
| work_keys_str_mv | AT veraavokina alterationsincnsfunctionsanddnamethylationinratsafter24hexposuretopeatsmoke AT larisamsosedova alterationsincnsfunctionsanddnamethylationinratsafter24hexposuretopeatsmoke AT mikhailanovikov alterationsincnsfunctionsanddnamethylationinratsafter24hexposuretopeatsmoke AT viktorsrukavishnikov alterationsincnsfunctionsanddnamethylationinratsafter24hexposuretopeatsmoke AT ekaterinaakapustina alterationsincnsfunctionsanddnamethylationinratsafter24hexposuretopeatsmoke AT antonnalekseenko alterationsincnsfunctionsanddnamethylationinratsafter24hexposuretopeatsmoke AT elizavetasandreeva alterationsincnsfunctionsanddnamethylationinratsafter24hexposuretopeatsmoke |