Predictive value of serum adenosine deaminase levels in prospect of tubercular infections
Background: Tuberculosis (TB) is well-known public health problem with one-fifth of global burden in India. Even though there are diagnostic and prognostic markers for TB, there is further need to study and understand the role of adenosine deaminase (ADA) in different forms of TB for its rapid contr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Biomedical and Biotechnology Research Journal |
| Subjects: | |
| Online Access: | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2019;volume=3;issue=2;spage=105;epage=108;aulast=Lende |
| _version_ | 1811270627055632384 |
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| author | Trupti G Lende Pranita Waghmare Abhaykumar W Ambilkar Satish Kumar |
| author_facet | Trupti G Lende Pranita Waghmare Abhaykumar W Ambilkar Satish Kumar |
| author_sort | Trupti G Lende |
| collection | DOAJ |
| description | Background: Tuberculosis (TB) is well-known public health problem with one-fifth of global burden in India. Even though there are diagnostic and prognostic markers for TB, there is further need to study and understand the role of adenosine deaminase (ADA) in different forms of TB for its rapid control. The present study is conducted to ascertain the role of biochemical enzymatic marker, i.e., ADA in different forms of TB and in Bacillus Calmette–Guérin-vaccinated healthy controls. The aim is to study the role of ADA in different forms of TB compared with healthy controls. This cross-sectional study was conducted on patients attending outpatient department under a district tuberculosis center. Methods: A total 100 participants 25 in each study group and 25 in healthy control were enrolled. After taking sociodemographic profile and detailed history, serum levels of ADA were assessed and compared within study groups. Difference in level of ADA among different study groups was evaluated using the Kruskal–Wallis test. Receiver operating characteristic curve analysis was done to identify the cutoff values for ADA that has maximum sensitivity and specificity. Results: Of total 100 enrolled participants, 53 were males and 47 were females belonging to the age group range of 16–65 years. Among 75 participants who had TB, 68% had pulmonary and 32% had extrapulmonary TB. Levels of serum ADA were found to be significantly higher in relapse TB, fresh TB, and those on anti-TB treatment compared to healthy controls. Conclusions: Serum ADA levels may serve as prognostic markers in TB. |
| first_indexed | 2024-04-12T22:05:37Z |
| format | Article |
| id | doaj.art-a4a5278b18de4e3b8223ac600d7bf15a |
| institution | Directory Open Access Journal |
| issn | 2588-9834 2588-9842 |
| language | English |
| last_indexed | 2024-04-12T22:05:37Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Biomedical and Biotechnology Research Journal |
| spelling | doaj.art-a4a5278b18de4e3b8223ac600d7bf15a2022-12-22T03:14:58ZengWolters Kluwer Medknow PublicationsBiomedical and Biotechnology Research Journal2588-98342588-98422019-01-013210510810.4103/bbrj.bbrj_51_19Predictive value of serum adenosine deaminase levels in prospect of tubercular infectionsTrupti G LendePranita WaghmareAbhaykumar W AmbilkarSatish KumarBackground: Tuberculosis (TB) is well-known public health problem with one-fifth of global burden in India. Even though there are diagnostic and prognostic markers for TB, there is further need to study and understand the role of adenosine deaminase (ADA) in different forms of TB for its rapid control. The present study is conducted to ascertain the role of biochemical enzymatic marker, i.e., ADA in different forms of TB and in Bacillus Calmette–Guérin-vaccinated healthy controls. The aim is to study the role of ADA in different forms of TB compared with healthy controls. This cross-sectional study was conducted on patients attending outpatient department under a district tuberculosis center. Methods: A total 100 participants 25 in each study group and 25 in healthy control were enrolled. After taking sociodemographic profile and detailed history, serum levels of ADA were assessed and compared within study groups. Difference in level of ADA among different study groups was evaluated using the Kruskal–Wallis test. Receiver operating characteristic curve analysis was done to identify the cutoff values for ADA that has maximum sensitivity and specificity. Results: Of total 100 enrolled participants, 53 were males and 47 were females belonging to the age group range of 16–65 years. Among 75 participants who had TB, 68% had pulmonary and 32% had extrapulmonary TB. Levels of serum ADA were found to be significantly higher in relapse TB, fresh TB, and those on anti-TB treatment compared to healthy controls. Conclusions: Serum ADA levels may serve as prognostic markers in TB.http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2019;volume=3;issue=2;spage=105;epage=108;aulast=LendePredictive valueserum adenosine deaminasetuberculosis |
| spellingShingle | Trupti G Lende Pranita Waghmare Abhaykumar W Ambilkar Satish Kumar Predictive value of serum adenosine deaminase levels in prospect of tubercular infections Biomedical and Biotechnology Research Journal Predictive value serum adenosine deaminase tuberculosis |
| title | Predictive value of serum adenosine deaminase levels in prospect of tubercular infections |
| title_full | Predictive value of serum adenosine deaminase levels in prospect of tubercular infections |
| title_fullStr | Predictive value of serum adenosine deaminase levels in prospect of tubercular infections |
| title_full_unstemmed | Predictive value of serum adenosine deaminase levels in prospect of tubercular infections |
| title_short | Predictive value of serum adenosine deaminase levels in prospect of tubercular infections |
| title_sort | predictive value of serum adenosine deaminase levels in prospect of tubercular infections |
| topic | Predictive value serum adenosine deaminase tuberculosis |
| url | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2019;volume=3;issue=2;spage=105;epage=108;aulast=Lende |
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