PEGylated Liposomal Methyl Prednisolone Succinate does not Induce Infusion Reactions in Patients: A Correlation Between in Vitro Immunological and in Vivo Clinical Studies

PEGylated Liposomal Methyl Prednisolone Succinate does not Induce Infusion Reactions in Patients: A Correlation Between in Vitro Immunological and in Vivo Clinical Studies

PEGylated nanomedicines are known to induce infusion reactions (IRs) that in some cases can be life-threatening. Herein, we report a case study in which a patient with rare mediastinal and intracardiac IgG4-related sclerosing disease received 8 treatments of intravenously administered PEGylated lipo...

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Bibliographic Details
Main Authors: Yaelle Bavli, Bing-Mae Chen, Steve R. Roffler, Marina A. Dobrovolskaia, Eldad Elnekave, Shifra Ash, Yechezkel Barenholz, Keren Turjeman
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
pegylated nanodrugs
hypersensitive reactions
anti-peg antibodies
complement activation
liposomal steroids
igg4 related disease
Online Access:https://www.mdpi.com/1420-3049/25/3/558

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