Choroidal thickness in thyroid eye disease and its correlation with disease activity
Context: This study adds to the existing body of literature on the role of optical coherence tomography (OCT) parameters in active thyroid eye disease (TED) among the Indian population. Purpose: Comparison of choroidal vascularity index (CVI) and subfoveal choroidal thickness (SFCT) in active and in...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2024;volume=72;issue=2;spage=281;epage=286;aulast=Muralidhar |
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| author | Alankrita Muralidhar Shalini Singh Sima Das Kheyali Mondal Brajesh Kumar Manisha Agarwal Atanu Majumdar |
| author_facet | Alankrita Muralidhar Shalini Singh Sima Das Kheyali Mondal Brajesh Kumar Manisha Agarwal Atanu Majumdar |
| author_sort | Alankrita Muralidhar |
| collection | DOAJ |
| description | Context: This study adds to the existing body of literature on the role of optical coherence tomography (OCT) parameters in active thyroid eye disease (TED) among the Indian population. Purpose: Comparison of choroidal vascularity index (CVI) and subfoveal choroidal thickness (SFCT) in active and inactive TED. Settings and Design: An observational, cross-sectional analytical study conducted at a tertiary eye care hospital in North India that included patients with active and inactive TED. Methods: Demographic details and clinical evaluation were performed for all TED patients. SFCT was determined with OCT by using the Cirrus linear measurement tool. CVI was calculated using Image J software. The SFCT and CVI measurements were compared between both groups. Statistical Analysis Used: Comparison between active and inactive TED groups was done using Mann–Whitney U test for non-parametric data and Student t test for parametric data. Multivariate regression analysis was performed with SFCT and CVI as dependent variables. Results: Sixty-two eyes of 31 patients were included. Thirteen eyes had active TED, and 49 eyes had inactive TED. SFCT was significantly lower in eyes with higher clinical activity score (CAS) and older age. No significant difference was found in CVI between active and inactive TED eyes. Conclusion: SFCT was lower in eyes with higher CAS and older age. Our findings differ from previous studies, which showed a positive correlation between SFCT and CAS. There was no significant difference in CVI between active and inactive TED eyes. |
| first_indexed | 2024-04-24T14:15:23Z |
| format | Article |
| id | doaj.art-a4a64a1d65fe43da9d8aec998634498b |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-04-24T14:15:23Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-a4a64a1d65fe43da9d8aec998634498b2024-04-03T08:54:29ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892024-01-0172228128610.4103/IJO.IJO_848_23Choroidal thickness in thyroid eye disease and its correlation with disease activityAlankrita MuralidharShalini SinghSima DasKheyali MondalBrajesh KumarManisha AgarwalAtanu MajumdarContext: This study adds to the existing body of literature on the role of optical coherence tomography (OCT) parameters in active thyroid eye disease (TED) among the Indian population. Purpose: Comparison of choroidal vascularity index (CVI) and subfoveal choroidal thickness (SFCT) in active and inactive TED. Settings and Design: An observational, cross-sectional analytical study conducted at a tertiary eye care hospital in North India that included patients with active and inactive TED. Methods: Demographic details and clinical evaluation were performed for all TED patients. SFCT was determined with OCT by using the Cirrus linear measurement tool. CVI was calculated using Image J software. The SFCT and CVI measurements were compared between both groups. Statistical Analysis Used: Comparison between active and inactive TED groups was done using Mann–Whitney U test for non-parametric data and Student t test for parametric data. Multivariate regression analysis was performed with SFCT and CVI as dependent variables. Results: Sixty-two eyes of 31 patients were included. Thirteen eyes had active TED, and 49 eyes had inactive TED. SFCT was significantly lower in eyes with higher clinical activity score (CAS) and older age. No significant difference was found in CVI between active and inactive TED eyes. Conclusion: SFCT was lower in eyes with higher CAS and older age. Our findings differ from previous studies, which showed a positive correlation between SFCT and CAS. There was no significant difference in CVI between active and inactive TED eyes.http://www.ijo.in/article.asp?issn=0301-4738;year=2024;volume=72;issue=2;spage=281;epage=286;aulast=Muralidharactive thyroid eye diseasechoroidal vascularity indexsubfoveal choroidal thicknessthyroid eye disease |
| spellingShingle | Alankrita Muralidhar Shalini Singh Sima Das Kheyali Mondal Brajesh Kumar Manisha Agarwal Atanu Majumdar Choroidal thickness in thyroid eye disease and its correlation with disease activity Indian Journal of Ophthalmology active thyroid eye disease choroidal vascularity index subfoveal choroidal thickness thyroid eye disease |
| title | Choroidal thickness in thyroid eye disease and its correlation with disease activity |
| title_full | Choroidal thickness in thyroid eye disease and its correlation with disease activity |
| title_fullStr | Choroidal thickness in thyroid eye disease and its correlation with disease activity |
| title_full_unstemmed | Choroidal thickness in thyroid eye disease and its correlation with disease activity |
| title_short | Choroidal thickness in thyroid eye disease and its correlation with disease activity |
| title_sort | choroidal thickness in thyroid eye disease and its correlation with disease activity |
| topic | active thyroid eye disease choroidal vascularity index subfoveal choroidal thickness thyroid eye disease |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2024;volume=72;issue=2;spage=281;epage=286;aulast=Muralidhar |
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