Meningioma associated with reactive hyperplasia and colonization of melanocytes
Objective To summarize the clinical features, diagnosis and differential diagnosis of a case of meningioma associated with reactive hyperplasia and colonization of melanocytes. Methods and Results A 24⁃years⁃old female was discovered a left occipital lobe occupying occasionally by the head CT and MR...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2021-06-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2348 |
| _version_ | 1819289901025198080 |
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| author | SONG Kun WANG Juan CHAI Xue ZHANG Yu⁃mei YAN Chun⁃yan ZHOU Jin⁃bao ZHU Hai⁃qing |
| author_facet | SONG Kun WANG Juan CHAI Xue ZHANG Yu⁃mei YAN Chun⁃yan ZHOU Jin⁃bao ZHU Hai⁃qing |
| author_sort | SONG Kun |
| collection | DOAJ |
| description | Objective To summarize the clinical features, diagnosis and differential diagnosis of a case of meningioma associated with reactive hyperplasia and colonization of melanocytes. Methods and Results A 24⁃years⁃old female was discovered a left occipital lobe occupying occasionally by the head CT and MRI. The tumor revealed heterogeneous hyperintense and hypointense signals on T1WI and heterogeneous isointense and hypointense signals on T2WI with enhancement obviously. The left occipital lobe tumor was diagnosed clinically, and the left occipital posterior approach craniotomy was performed under general anesthesia. During operation, there was a smooth capsule on the surface of the tumor partially, which was dark in color and extremely rich in blood supply. Histological findings revealed the tumor cells were distributed in patches, and some of them were around blood vessels characterized by a prominent pseudopapillary architecture. Tumor cells were medium in size and eosinophilic cytoplasm was abundant. Giant tumor cells, intranuclear inclusion and scattered psammoma bodies were visible. A large number of pigmented cells consisted of dark, fine pigment granules. Immunohistochemical staining showed tumor cells expressed vimentin (Vim), E⁃cadherin, progesterone receptor (PR). Somatostatin receptor 2 (SSTR2), glial fibrillary acidic protein (GFAP), S⁃100 protein (S⁃100) presented partially positive. Melanosome⁃associated antigen (HMB45), Melan⁃A, epithelial membrane antigen (EMA), cytokeratin (CK), low molecular weight cytokeratin (LCK), high molecular weight cytokeratin (HCK), SOX10, L1⁃cell adhesion molecule (L1CAM), D2⁃40 and oligodendrocyte transcription factor⁃2 (Olig⁃2) were negative, but the pigmented cells were immunopositive for HMB45, SOX10. Genetic test revealed deletion of NF2 gene. The final diagnosis was meningioma associated with reactive hyperplasia and colonization of melanocytes. No chemoradiotherapy was performed after operation, and no recurrence of tumor was found by MRI. Conclusions Meningioma associated with reactive hyperplasia and colonization of melanocytes is a rare neoplasm. The diagnosis relies on its morphological characteristics, immunophenotype and genetic test. It should be differentiated from other tumors with melanocytes in the central nervous system. |
| first_indexed | 2024-12-24T03:14:12Z |
| format | Article |
| id | doaj.art-a4a6749372f9410385f5efaec8823b25 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 1672-6731 |
| language | English |
| last_indexed | 2024-12-24T03:14:12Z |
| publishDate | 2021-06-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-a4a6749372f9410385f5efaec8823b252022-12-21T17:17:42ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67311672-67312021-06-01210648549210.3969/j.issn.1672⁃6731.2021.06.011Meningioma associated with reactive hyperplasia and colonization of melanocytesSONG Kun0WANG Juan1 CHAI Xue 2 ZHANG Yu⁃mei3YAN Chun⁃yan4 ZHOU Jin⁃bao5ZHU Hai⁃qing6 Department of Pathology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaDepartment of Pathology,The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaDepartment of Pathology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China Department of Pathology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaDepartment of Pathology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China Department of Pathology,The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaObjective To summarize the clinical features, diagnosis and differential diagnosis of a case of meningioma associated with reactive hyperplasia and colonization of melanocytes. Methods and Results A 24⁃years⁃old female was discovered a left occipital lobe occupying occasionally by the head CT and MRI. The tumor revealed heterogeneous hyperintense and hypointense signals on T1WI and heterogeneous isointense and hypointense signals on T2WI with enhancement obviously. The left occipital lobe tumor was diagnosed clinically, and the left occipital posterior approach craniotomy was performed under general anesthesia. During operation, there was a smooth capsule on the surface of the tumor partially, which was dark in color and extremely rich in blood supply. Histological findings revealed the tumor cells were distributed in patches, and some of them were around blood vessels characterized by a prominent pseudopapillary architecture. Tumor cells were medium in size and eosinophilic cytoplasm was abundant. Giant tumor cells, intranuclear inclusion and scattered psammoma bodies were visible. A large number of pigmented cells consisted of dark, fine pigment granules. Immunohistochemical staining showed tumor cells expressed vimentin (Vim), E⁃cadherin, progesterone receptor (PR). Somatostatin receptor 2 (SSTR2), glial fibrillary acidic protein (GFAP), S⁃100 protein (S⁃100) presented partially positive. Melanosome⁃associated antigen (HMB45), Melan⁃A, epithelial membrane antigen (EMA), cytokeratin (CK), low molecular weight cytokeratin (LCK), high molecular weight cytokeratin (HCK), SOX10, L1⁃cell adhesion molecule (L1CAM), D2⁃40 and oligodendrocyte transcription factor⁃2 (Olig⁃2) were negative, but the pigmented cells were immunopositive for HMB45, SOX10. Genetic test revealed deletion of NF2 gene. The final diagnosis was meningioma associated with reactive hyperplasia and colonization of melanocytes. No chemoradiotherapy was performed after operation, and no recurrence of tumor was found by MRI. Conclusions Meningioma associated with reactive hyperplasia and colonization of melanocytes is a rare neoplasm. The diagnosis relies on its morphological characteristics, immunophenotype and genetic test. It should be differentiated from other tumors with melanocytes in the central nervous system.http://www.cjcnn.org/index.php/cjcnn/article/view/2348meningiomamelanocytescell transplantationcell proliferationimmunohistochemistrypathology |
| spellingShingle | SONG Kun WANG Juan CHAI Xue ZHANG Yu⁃mei YAN Chun⁃yan ZHOU Jin⁃bao ZHU Hai⁃qing Meningioma associated with reactive hyperplasia and colonization of melanocytes Chinese Journal of Contemporary Neurology and Neurosurgery meningioma melanocytes cell transplantation cell proliferation immunohistochemistry pathology |
| title | Meningioma associated with reactive hyperplasia and colonization of melanocytes |
| title_full | Meningioma associated with reactive hyperplasia and colonization of melanocytes |
| title_fullStr | Meningioma associated with reactive hyperplasia and colonization of melanocytes |
| title_full_unstemmed | Meningioma associated with reactive hyperplasia and colonization of melanocytes |
| title_short | Meningioma associated with reactive hyperplasia and colonization of melanocytes |
| title_sort | meningioma associated with reactive hyperplasia and colonization of melanocytes |
| topic | meningioma melanocytes cell transplantation cell proliferation immunohistochemistry pathology |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2348 |
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