A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S
Inspired by biological channels, the electric signal-based artificial nanochannel system exhibits high sensitivity in various analyses. However, ion current may be affected by many other factors, leading to false-positive signals. For reliable detection, in this work, we apply a facile strategy to c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/9/11/298 |
| _version_ | 1797510811968602112 |
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| author | I Wu Dan Zhang Xuanjun Zhang |
| author_facet | I Wu Dan Zhang Xuanjun Zhang |
| author_sort | I Wu |
| collection | DOAJ |
| description | Inspired by biological channels, the electric signal-based artificial nanochannel system exhibits high sensitivity in various analyses. However, ion current may be affected by many other factors, leading to false-positive signals. For reliable detection, in this work, we apply a facile strategy to combine both current signal and fluorescence. Fluorescent probes were conjugated to the nanochannel surface by covalent bonds. By utilizing the specific reduction of azide groups in the probe to amino groups by H<sub>2</sub>S, a synchronizing change in fluorescence and nanochannel surface charge was established. As a result, both transmembrane ion current and fluorescence intensity showed significant changes. The photoelectric double-checked locking from temporal and spatial variation validly confirmed the response process and protected detection accuracy. The work may provide new ideas for the development of more sophisticated current and fluorescence dual-index nanochannel systems. |
| first_indexed | 2024-03-10T05:36:34Z |
| format | Article |
| id | doaj.art-a4a85ebbdcd84d7f8689daac5b186a2c |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-10T05:36:34Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-a4a85ebbdcd84d7f8689daac5b186a2c2023-11-22T22:53:46ZengMDPI AGChemosensors2227-90402021-10-0191129810.3390/chemosensors9110298A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>SI Wu0Dan Zhang1Xuanjun Zhang2Faculty of Health Sciences, University of Macau, Macau 999078, ChinaFaculty of Health Sciences, University of Macau, Macau 999078, ChinaFaculty of Health Sciences, University of Macau, Macau 999078, ChinaInspired by biological channels, the electric signal-based artificial nanochannel system exhibits high sensitivity in various analyses. However, ion current may be affected by many other factors, leading to false-positive signals. For reliable detection, in this work, we apply a facile strategy to combine both current signal and fluorescence. Fluorescent probes were conjugated to the nanochannel surface by covalent bonds. By utilizing the specific reduction of azide groups in the probe to amino groups by H<sub>2</sub>S, a synchronizing change in fluorescence and nanochannel surface charge was established. As a result, both transmembrane ion current and fluorescence intensity showed significant changes. The photoelectric double-checked locking from temporal and spatial variation validly confirmed the response process and protected detection accuracy. The work may provide new ideas for the development of more sophisticated current and fluorescence dual-index nanochannel systems.https://www.mdpi.com/2227-9040/9/11/298biomimetic nanochannelscurrentfluorescencedual-signal sensingH<sub>2</sub>S |
| spellingShingle | I Wu Dan Zhang Xuanjun Zhang A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S Chemosensors biomimetic nanochannels current fluorescence dual-signal sensing H<sub>2</sub>S |
| title | A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S |
| title_full | A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S |
| title_fullStr | A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S |
| title_full_unstemmed | A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S |
| title_short | A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S |
| title_sort | facile strategy for the ion current and fluorescence dual lock in detection naphthalic anhydride azide naa modified biomimetic nanochannel sensor towards h sub 2 sub s |
| topic | biomimetic nanochannels current fluorescence dual-signal sensing H<sub>2</sub>S |
| url | https://www.mdpi.com/2227-9040/9/11/298 |
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