Neuronal fate specification by the Dbx1 transcription factor is linked to the evolutionary acquisition of a novel functional domain

Neuronal fate specification by the Dbx1 transcription factor is linked to the evolutionary acquisition of a novel functional domain

Abstract Background Dbx1 is a homeodomain transcription factor involved in neuronal fate specification belonging to a widely conserved family among bilaterians. In mammals, Dbx1 was proposed to act as a transcriptional repressor by interacting with the Groucho corepressors to allow the specification...

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Bibliographic Details
Main Authors: Sonia Karaz, Maximilien Courgeon, Hélène Lepetit, Eugenia Bruno, Raimondo Pannone, Andrea Tarallo, France Thouzé, Pierre Kerner, Michel Vervoort, Frédéric Causeret, Alessandra Pierani, Giuseppe D’Onofrio
Format: Article
Language:English
Published: BMC 2016-08-01
Series:EvoDevo
Subjects:
Nervous system
Spinal cord
Neuronal identity
Transcription factor
Protein domains
Online Access:http://link.springer.com/article/10.1186/s13227-016-0055-5

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