THE ROLE OF POLYMORPHISM OF LIPID METABOLISM GENES IN THE PATHOGENESIS OF PREECLAMPSIA
Violation of lipid metabolism with the formation of atherogenic factors and subsequent endothelial dysfunction is one of the concepts explaining the pathogenesis of preeclampsia. Polymorphism of ApoE, CETP, and LPL genes can influence the course of pregnancy, provoking maternal dyslipidemia. The a...
| 主要な著者: | , , , , , |
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| フォーマット: | 論文 |
| 言語: | Russian |
| 出版事項: |
The Publishing House Medicine and Enlightenment
2023-07-01
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| シリーズ: | Мать и дитя в Кузбассе |
| 主題: | |
| オンライン･アクセス: | https://mednauki.ru/index.php/MD/article/view/913 |
| _version_ | 1827755136501415936 |
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| author | Артем Алексеевич Денисов Анастасия Константиновна Петриченко Надежда Васильевна Башмакова Татьяна Борисовна Третьякова Наталья Борисовна Давыденко Людмила Анатольевна Пестряева |
| author_facet | Артем Алексеевич Денисов Анастасия Константиновна Петриченко Надежда Васильевна Башмакова Татьяна Борисовна Третьякова Наталья Борисовна Давыденко Людмила Анатольевна Пестряева |
| author_sort | Артем Алексеевич Денисов |
| collection | DOAJ |
| description | Violation of lipid metabolism with the formation of atherogenic factors and subsequent endothelial dysfunction is one of the concepts explaining the pathogenesis of preeclampsia.
Polymorphism of ApoE, CETP, and LPL genes can influence the course of pregnancy, provoking maternal dyslipidemia.
The aim of the study – to study the clinical and anemnestic features of patients with preeclampsia and women with a high risk of preeclampsia; to compare the data of biochemical tests of the data of both groups of patients, as well as to determine the role of polymorphism of lipid metabolism genes as risk factors for preeclampsia.
Materials and methods. A prospective cohort comparative study of 60 patients was conducted, of which the main group consisted of 30 women with moderate and severe preeclampsia and 30 patients with a high risk of developing preeclampsia according to prenatal screening of the first trimester, who made up the comparison group. In the course of the study, anamnestic factors, features of lipid metabolism and the results of genetic studies were analyzed.
Conclusion. The conducted studies showed a significant difference in the features of the obstetric and gynecological anamnesis of both groups of patients, lipidogram indicators, as well as in the distribution of alleles and genotypes in the group of women with realized preeclampsia by polymorphic markers ApoE 388 T>C and CETP 1264 G>A. There was no difference in the distribution of alleles and genotypes of the LPL 447 C>G gene. |
| first_indexed | 2024-03-11T07:58:59Z |
| format | Article |
| id | doaj.art-a4aa07edfe0b42b99b0b51be6062c815 |
| institution | Directory Open Access Journal |
| issn | 1991-010X 2542-0968 |
| language | Russian |
| last_indexed | 2024-03-11T07:58:59Z |
| publishDate | 2023-07-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Мать и дитя в Кузбассе |
| spelling | doaj.art-a4aa07edfe0b42b99b0b51be6062c8152023-11-17T02:53:06ZrusThe Publishing House Medicine and EnlightenmentМать и дитя в Кузбассе1991-010X2542-09682023-07-012435260815THE ROLE OF POLYMORPHISM OF LIPID METABOLISM GENES IN THE PATHOGENESIS OF PREECLAMPSIAАртем Алексеевич Денисов0Анастасия Константиновна Петриченко1Надежда Васильевна Башмакова2Татьяна Борисовна Третьякова3Наталья Борисовна Давыденко4Людмила Анатольевна Пестряева5ФГБУ «НИИ ОММ» Минздрава России, г. ЕкатеринбургФГБУ «НИИ ОММ» Минздрава России, г. ЕкатеринбургФГБУ «НИИ ОММ» Минздрава России, г. ЕкатеринбургФГБУ «НИИ ОММ» Минздрава России, г. ЕкатеринбургФГБУ «НИИ ОММ» Минздрава России, г. ЕкатеринбургФГБУ «НИИ ОММ» Минздрава России, г. ЕкатеринбургViolation of lipid metabolism with the formation of atherogenic factors and subsequent endothelial dysfunction is one of the concepts explaining the pathogenesis of preeclampsia. Polymorphism of ApoE, CETP, and LPL genes can influence the course of pregnancy, provoking maternal dyslipidemia. The aim of the study – to study the clinical and anemnestic features of patients with preeclampsia and women with a high risk of preeclampsia; to compare the data of biochemical tests of the data of both groups of patients, as well as to determine the role of polymorphism of lipid metabolism genes as risk factors for preeclampsia. Materials and methods. A prospective cohort comparative study of 60 patients was conducted, of which the main group consisted of 30 women with moderate and severe preeclampsia and 30 patients with a high risk of developing preeclampsia according to prenatal screening of the first trimester, who made up the comparison group. In the course of the study, anamnestic factors, features of lipid metabolism and the results of genetic studies were analyzed. Conclusion. The conducted studies showed a significant difference in the features of the obstetric and gynecological anamnesis of both groups of patients, lipidogram indicators, as well as in the distribution of alleles and genotypes in the group of women with realized preeclampsia by polymorphic markers ApoE 388 T>C and CETP 1264 G>A. There was no difference in the distribution of alleles and genotypes of the LPL 447 C>G gene.https://mednauki.ru/index.php/MD/article/view/913преэклампсиягеныобменлипидытриглицериды |
| spellingShingle | Артем Алексеевич Денисов Анастасия Константиновна Петриченко Надежда Васильевна Башмакова Татьяна Борисовна Третьякова Наталья Борисовна Давыденко Людмила Анатольевна Пестряева THE ROLE OF POLYMORPHISM OF LIPID METABOLISM GENES IN THE PATHOGENESIS OF PREECLAMPSIA Мать и дитя в Кузбассе преэклампсия гены обмен липиды триглицериды |
| title | THE ROLE OF POLYMORPHISM OF LIPID METABOLISM GENES IN THE PATHOGENESIS OF PREECLAMPSIA |
| title_full | THE ROLE OF POLYMORPHISM OF LIPID METABOLISM GENES IN THE PATHOGENESIS OF PREECLAMPSIA |
| title_fullStr | THE ROLE OF POLYMORPHISM OF LIPID METABOLISM GENES IN THE PATHOGENESIS OF PREECLAMPSIA |
| title_full_unstemmed | THE ROLE OF POLYMORPHISM OF LIPID METABOLISM GENES IN THE PATHOGENESIS OF PREECLAMPSIA |
| title_short | THE ROLE OF POLYMORPHISM OF LIPID METABOLISM GENES IN THE PATHOGENESIS OF PREECLAMPSIA |
| title_sort | role of polymorphism of lipid metabolism genes in the pathogenesis of preeclampsia |
| topic | преэклампсия гены обмен липиды триглицериды |
| url | https://mednauki.ru/index.php/MD/article/view/913 |
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