Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractio
Objectives: Enhanced matrix metalloproteinase-8 (MMP-8) activity in the early post-myocardial infarction (MI) period has been related to early remodeling. However, it has been demonstrated that plasma MMP-8 level has a biphasic profile, and the relation between the late plasma levels and remodeling...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2013-10-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-68625 |
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| author | Ayhan Erkol Selçuk Pala Vecih Oduncu Alev Kılıcgedik Filiz Kızılırmak Can Yücel Karabay Ahmet Güler Cevat Kırma |
| author_facet | Ayhan Erkol Selçuk Pala Vecih Oduncu Alev Kılıcgedik Filiz Kızılırmak Can Yücel Karabay Ahmet Güler Cevat Kırma |
| author_sort | Ayhan Erkol |
| collection | DOAJ |
| description | Objectives: Enhanced matrix metalloproteinase-8 (MMP-8) activity in the early post-myocardial infarction (MI) period has been related to early remodeling. However, it has been demonstrated that plasma MMP-8 level has a biphasic profile, and the relation between the late plasma levels and remodeling is unclear. We evaluated the plasma MMP-8 levels and its correlates 20+-3 months after acute MI.
Study design: 58 post-MI patients and 26 control subjects underwent quantitative single-photon emission computed tomography (SPECT) and echocardiography. The plasma MMP-8 levels were measured and its correlates were investigated.
Results: The MMP-8 levels were significantly higher in post- MI patients [median 3.88 ng/ml, interquartile range (1.88- 6.43) vs. 0.67 ng/ml (0.34-2.47); p<0.001]. Plasma MMP-8 levels were significantly correlated with left ventricular ejection fraction (LVEF) (ρ=0.34, p=0.009), end diastolic volume index (EDVi) (ρ=-0.39, p=0.002) and end systolic volume index (ESVi) (ρ=-0.40, p=0.002).
Conclusion: Plasma MMP-8 levels were found to still be high in post-MI patients 20+-3 months after the index event. The levels were significantly correlated with left ventricular volume indices and LVEF. We speculate that, in contrast to the relation between the higher early MMP-8 activity and the extent of cardiac remodeling, higher late levels may be associated with relative preservation of left ventricular systolic function. |
| first_indexed | 2024-04-10T14:00:17Z |
| format | Article |
| id | doaj.art-a4aa42bc6ba646ddb292441d445124f3 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T14:00:17Z |
| publishDate | 2013-10-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-a4aa42bc6ba646ddb292441d445124f32023-02-15T16:10:19ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692013-10-0141761762410.5543/tkda.2013.68625TKDA-68625Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractioAyhan Erkol0Selçuk Pala1Vecih Oduncu2Alev Kılıcgedik3Filiz Kızılırmak4Can Yücel Karabay5Ahmet Güler6Cevat Kırma7Department of Cardiology, Kocaeli Derince Training and Research Hospital, Kocaeli, TurkeyDepartment of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, TurkeyDepartment of Cardiology Fatih Medikal Park Hospital, IstanbulDepartment of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, TurkeyDepartment of Cardiology, Medipol University Hospital, IstanbulDepartment of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, TurkeyDepartment of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, TurkeyDepartment of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, TurkeyObjectives: Enhanced matrix metalloproteinase-8 (MMP-8) activity in the early post-myocardial infarction (MI) period has been related to early remodeling. However, it has been demonstrated that plasma MMP-8 level has a biphasic profile, and the relation between the late plasma levels and remodeling is unclear. We evaluated the plasma MMP-8 levels and its correlates 20+-3 months after acute MI. Study design: 58 post-MI patients and 26 control subjects underwent quantitative single-photon emission computed tomography (SPECT) and echocardiography. The plasma MMP-8 levels were measured and its correlates were investigated. Results: The MMP-8 levels were significantly higher in post- MI patients [median 3.88 ng/ml, interquartile range (1.88- 6.43) vs. 0.67 ng/ml (0.34-2.47); p<0.001]. Plasma MMP-8 levels were significantly correlated with left ventricular ejection fraction (LVEF) (ρ=0.34, p=0.009), end diastolic volume index (EDVi) (ρ=-0.39, p=0.002) and end systolic volume index (ESVi) (ρ=-0.40, p=0.002). Conclusion: Plasma MMP-8 levels were found to still be high in post-MI patients 20+-3 months after the index event. The levels were significantly correlated with left ventricular volume indices and LVEF. We speculate that, in contrast to the relation between the higher early MMP-8 activity and the extent of cardiac remodeling, higher late levels may be associated with relative preservation of left ventricular systolic function.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-68625cardiac volumecoronary diseasebiological markers/ bloodelectrocardiography; ejection fraction; heart ventricles; matrix metalloproteinase 8; myocardial infarction/blood/enzymology. |
| spellingShingle | Ayhan Erkol Selçuk Pala Vecih Oduncu Alev Kılıcgedik Filiz Kızılırmak Can Yücel Karabay Ahmet Güler Cevat Kırma Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractio Türk Kardiyoloji Derneği Arşivi cardiac volume coronary disease biological markers/ blood electrocardiography; ejection fraction; heart ventricles; matrix metalloproteinase 8; myocardial infarction/blood/enzymology. |
| title | Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractio |
| title_full | Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractio |
| title_fullStr | Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractio |
| title_full_unstemmed | Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractio |
| title_short | Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fractio |
| title_sort | relation of plasma matrix metalloproteinase 8 levels late after myocardial infarction with left ventricular volumes and ejection fractio |
| topic | cardiac volume coronary disease biological markers/ blood electrocardiography; ejection fraction; heart ventricles; matrix metalloproteinase 8; myocardial infarction/blood/enzymology. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-68625 |
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