Characteristics, Outcomes, and Factors Affecting Mortality in Hospitalized Patients with CAP Due to Different Variants of SARS-CoV-2 and Non-COVID-19 CAP
The study was conducted from October 2020 to March 2022 in a province in southern Thailand. The inpatients with community-acquired pneumonia (CAP) and more than 18 years old were enrolled. Of the 1511 inpatients with CAP, COVID-19 was the leading cause, accounting for 27%. Among the patients with CO...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1388 |
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| author | Nonthanat Tongsengkee Smonrapat Surasombatpattana Wiwatana Tanomkiat Pisud Siripaitoon Narongdet Kositpantawong Siripen Kanchanasuwan Asma Navasakulpong Nawamin Pinpathomrat Arunee Dechaphunkul Atthaphong Phongphithakchai Thanaporn Hortiwakul Boonsri Charoenmak Sarunyou Chusri |
| author_facet | Nonthanat Tongsengkee Smonrapat Surasombatpattana Wiwatana Tanomkiat Pisud Siripaitoon Narongdet Kositpantawong Siripen Kanchanasuwan Asma Navasakulpong Nawamin Pinpathomrat Arunee Dechaphunkul Atthaphong Phongphithakchai Thanaporn Hortiwakul Boonsri Charoenmak Sarunyou Chusri |
| author_sort | Nonthanat Tongsengkee |
| collection | DOAJ |
| description | The study was conducted from October 2020 to March 2022 in a province in southern Thailand. The inpatients with community-acquired pneumonia (CAP) and more than 18 years old were enrolled. Of the 1511 inpatients with CAP, COVID-19 was the leading cause, accounting for 27%. Among the patients with COVID-19 CAP, mortalities, mechanical ventilators, ICU admissions, ICU stay, and hospital costs were significantly higher than of those with non-COVID-19 CAP. Household and workplace contact with COVID-19, co-morbidities, lymphocytopenia and peripheral infiltration in chest imaging were associated with CAP due to COVID-19. The delta variant yielded the most unfavorable clinical and non-clinical outcomes. While COVID-19 CAP due to B.1.113, Alpha and Omicron variants had relatively similar outcomes. Among those with CAP, COVID-19 infection as well as obesity, a higher Charlson comorbidity index (CCI) and APACHE II score were associated with in-hospital mortality. Among those with COVID-19 CAP, obesity, infection due to the Delta variant, a higher CCI and higher APACHE II score were associated with in-hospital mortality. COVID-19 had a great impact on the epidemiology and outcomes of CAP. |
| first_indexed | 2024-03-11T08:38:54Z |
| format | Article |
| id | doaj.art-a4ab02dac0b44697a4882392f4663255 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:38:54Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a4ab02dac0b44697a4882392f46632552023-11-16T21:18:51ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124138810.3390/jcm12041388Characteristics, Outcomes, and Factors Affecting Mortality in Hospitalized Patients with CAP Due to Different Variants of SARS-CoV-2 and Non-COVID-19 CAPNonthanat Tongsengkee0Smonrapat Surasombatpattana1Wiwatana Tanomkiat2Pisud Siripaitoon3Narongdet Kositpantawong4Siripen Kanchanasuwan5Asma Navasakulpong6Nawamin Pinpathomrat7Arunee Dechaphunkul8Atthaphong Phongphithakchai9Thanaporn Hortiwakul10Boonsri Charoenmak11Sarunyou Chusri12Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Pathology, Division of Virology and Serology, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Radiology, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandDepartment of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ThailandThe study was conducted from October 2020 to March 2022 in a province in southern Thailand. The inpatients with community-acquired pneumonia (CAP) and more than 18 years old were enrolled. Of the 1511 inpatients with CAP, COVID-19 was the leading cause, accounting for 27%. Among the patients with COVID-19 CAP, mortalities, mechanical ventilators, ICU admissions, ICU stay, and hospital costs were significantly higher than of those with non-COVID-19 CAP. Household and workplace contact with COVID-19, co-morbidities, lymphocytopenia and peripheral infiltration in chest imaging were associated with CAP due to COVID-19. The delta variant yielded the most unfavorable clinical and non-clinical outcomes. While COVID-19 CAP due to B.1.113, Alpha and Omicron variants had relatively similar outcomes. Among those with CAP, COVID-19 infection as well as obesity, a higher Charlson comorbidity index (CCI) and APACHE II score were associated with in-hospital mortality. Among those with COVID-19 CAP, obesity, infection due to the Delta variant, a higher CCI and higher APACHE II score were associated with in-hospital mortality. COVID-19 had a great impact on the epidemiology and outcomes of CAP.https://www.mdpi.com/2077-0383/12/4/1388SARS-CoV-2COVID-19community-acquired pneumoniaThailandepidemiologyoutcomes |
| spellingShingle | Nonthanat Tongsengkee Smonrapat Surasombatpattana Wiwatana Tanomkiat Pisud Siripaitoon Narongdet Kositpantawong Siripen Kanchanasuwan Asma Navasakulpong Nawamin Pinpathomrat Arunee Dechaphunkul Atthaphong Phongphithakchai Thanaporn Hortiwakul Boonsri Charoenmak Sarunyou Chusri Characteristics, Outcomes, and Factors Affecting Mortality in Hospitalized Patients with CAP Due to Different Variants of SARS-CoV-2 and Non-COVID-19 CAP Journal of Clinical Medicine SARS-CoV-2 COVID-19 community-acquired pneumonia Thailand epidemiology outcomes |
| title | Characteristics, Outcomes, and Factors Affecting Mortality in Hospitalized Patients with CAP Due to Different Variants of SARS-CoV-2 and Non-COVID-19 CAP |
| title_full | Characteristics, Outcomes, and Factors Affecting Mortality in Hospitalized Patients with CAP Due to Different Variants of SARS-CoV-2 and Non-COVID-19 CAP |
| title_fullStr | Characteristics, Outcomes, and Factors Affecting Mortality in Hospitalized Patients with CAP Due to Different Variants of SARS-CoV-2 and Non-COVID-19 CAP |
| title_full_unstemmed | Characteristics, Outcomes, and Factors Affecting Mortality in Hospitalized Patients with CAP Due to Different Variants of SARS-CoV-2 and Non-COVID-19 CAP |
| title_short | Characteristics, Outcomes, and Factors Affecting Mortality in Hospitalized Patients with CAP Due to Different Variants of SARS-CoV-2 and Non-COVID-19 CAP |
| title_sort | characteristics outcomes and factors affecting mortality in hospitalized patients with cap due to different variants of sars cov 2 and non covid 19 cap |
| topic | SARS-CoV-2 COVID-19 community-acquired pneumonia Thailand epidemiology outcomes |
| url | https://www.mdpi.com/2077-0383/12/4/1388 |
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