Novel bisphosphonate-based cathepsin K-triggered compound targets the enthesis without impairing soft tissue-to-bone healing

Novel bisphosphonate-based cathepsin K-triggered compound targets the enthesis without impairing soft tissue-to-bone healing

Background: Osteoadsorptive fluorogenic sentinel 3 (OFS-3) is a recently described compound that contains a bone-targeting bisphosphonate (BP) and cathepsin K (Ctsk)-triggered fluorescence signal. A prior study in a murine Achilles repair model demonstrated its effectiveness at targeting the site of...

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Bibliographic Details
Main Authors: Brendan Y. Shi, Varun Sriram, Shannon Y. Wu, Dave Huang, Alexis Cheney, Melodie F. Metzger, Oskar Sundberg, Karen M. Lyons, Charles E. McKenna, Ichiro Nishimura, Thomas J. Kremen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
enthesis
biomechanics
growth factor delivery
rotator cuff repair
targeted delivery
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1308161/full

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