Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders
Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence homology with the precursors of other opioid neuropeptides but it does not activate either MOP, KOP or DOP receptors. Furthermore, op...
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/12956 |
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| author | Massimo Ubaldi Nazzareno Cannella Anna Maria Borruto Michele Petrella Maria Vittoria Micioni Di Bonaventura Laura Soverchia Serena Stopponi Friedbert Weiss Carlo Cifani Roberto Ciccocioppo |
| author_facet | Massimo Ubaldi Nazzareno Cannella Anna Maria Borruto Michele Petrella Maria Vittoria Micioni Di Bonaventura Laura Soverchia Serena Stopponi Friedbert Weiss Carlo Cifani Roberto Ciccocioppo |
| author_sort | Massimo Ubaldi |
| collection | DOAJ |
| description | Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence homology with the precursors of other opioid neuropeptides but it does not activate either MOP, KOP or DOP receptors. Furthermore, opioid neuropeptides do not activate the NOP receptor. Generally, activation of N/OFQ system exerts anti-opioids effects, for instance toward opioid-induced reward and analgesia. The NOP receptor is widely expressed throughout the brain, whereas N/OFQ localization is confined to brain nuclei that are involved in stress response such as amygdala, BNST and hypothalamus. Decades of studies have delineated the biological role of this system demonstrating its involvement in significant physiological processes such as pain, learning and memory, anxiety, depression, feeding, drug and alcohol dependence. This review discusses the role of this peptidergic system in the modulation of stress and stress-associated psychiatric disorders in particular drug addiction, mood, anxiety and food-related associated-disorders. Emerging preclinical evidence suggests that both NOP agonists and antagonists may represent a effective therapeutic approaches for substances use disorder. Moreover, the current literature suggests that NOP antagonists can be useful to treat depression and feeding-related diseases, such as obesity and binge eating behavior, whereas the activation of NOP receptor by agonists could be a promising tool for anxiety. |
| first_indexed | 2024-03-10T04:52:32Z |
| format | Article |
| id | doaj.art-a4ac14a1302a4c59803b22b21c7f760e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:52:32Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a4ac14a1302a4c59803b22b21c7f760e2023-11-23T02:30:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122231295610.3390/ijms222312956Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related DisordersMassimo Ubaldi0Nazzareno Cannella1Anna Maria Borruto2Michele Petrella3Maria Vittoria Micioni Di Bonaventura4Laura Soverchia5Serena Stopponi6Friedbert Weiss7Carlo Cifani8Roberto Ciccocioppo9School of Pharmacy, University of Camerino, Via Madonna Delle Carceri 9, 62032 Camerino, ItalySchool of Pharmacy, University of Camerino, Via Madonna Delle Carceri 9, 62032 Camerino, ItalySchool of Pharmacy, University of Camerino, Via Madonna Delle Carceri 9, 62032 Camerino, ItalySchool of Pharmacy, University of Camerino, Via Madonna Delle Carceri 9, 62032 Camerino, ItalySchool of Pharmacy, University of Camerino, Via Madonna Delle Carceri 9, 62032 Camerino, ItalySchool of Pharmacy, University of Camerino, Via Madonna Delle Carceri 9, 62032 Camerino, ItalySchool of Pharmacy, University of Camerino, Via Madonna Delle Carceri 9, 62032 Camerino, ItalyDepartment of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USASchool of Pharmacy, University of Camerino, Via Madonna Delle Carceri 9, 62032 Camerino, ItalySchool of Pharmacy, University of Camerino, Via Madonna Delle Carceri 9, 62032 Camerino, ItalyNociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence homology with the precursors of other opioid neuropeptides but it does not activate either MOP, KOP or DOP receptors. Furthermore, opioid neuropeptides do not activate the NOP receptor. Generally, activation of N/OFQ system exerts anti-opioids effects, for instance toward opioid-induced reward and analgesia. The NOP receptor is widely expressed throughout the brain, whereas N/OFQ localization is confined to brain nuclei that are involved in stress response such as amygdala, BNST and hypothalamus. Decades of studies have delineated the biological role of this system demonstrating its involvement in significant physiological processes such as pain, learning and memory, anxiety, depression, feeding, drug and alcohol dependence. This review discusses the role of this peptidergic system in the modulation of stress and stress-associated psychiatric disorders in particular drug addiction, mood, anxiety and food-related associated-disorders. Emerging preclinical evidence suggests that both NOP agonists and antagonists may represent a effective therapeutic approaches for substances use disorder. Moreover, the current literature suggests that NOP antagonists can be useful to treat depression and feeding-related diseases, such as obesity and binge eating behavior, whereas the activation of NOP receptor by agonists could be a promising tool for anxiety.https://www.mdpi.com/1422-0067/22/23/12956nociceptin/orphanin FQNOP receptorstressaddiction |
| spellingShingle | Massimo Ubaldi Nazzareno Cannella Anna Maria Borruto Michele Petrella Maria Vittoria Micioni Di Bonaventura Laura Soverchia Serena Stopponi Friedbert Weiss Carlo Cifani Roberto Ciccocioppo Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders International Journal of Molecular Sciences nociceptin/orphanin FQ NOP receptor stress addiction |
| title | Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders |
| title_full | Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders |
| title_fullStr | Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders |
| title_full_unstemmed | Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders |
| title_short | Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders |
| title_sort | role of nociceptin orphanin fq nop receptor system in the regulation of stress related disorders |
| topic | nociceptin/orphanin FQ NOP receptor stress addiction |
| url | https://www.mdpi.com/1422-0067/22/23/12956 |
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