Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a review
Inflammation is an essential part of the immune response to injury and infection. Emerging evidence indicates that long-term low-grade inflammation is positively correlated with many diseases, such as cancer, metabolic disorders, and cardiovascular diseases. Due to common anti-inflammatory drugs are...
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| Format: | Article |
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Compuscript Ltd
2023-09-01
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| Series: | Acta Materia Medica |
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| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0026 |
| _version_ | 1827795954993987584 |
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| author | Cheng Chen Zheling Feng Jovana Petrović Marina Soković Yang Ye Ligen Lin |
| author_facet | Cheng Chen Zheling Feng Jovana Petrović Marina Soković Yang Ye Ligen Lin |
| author_sort | Cheng Chen |
| collection | DOAJ |
| description | Inflammation is an essential part of the immune response to injury and infection. Emerging evidence indicates that long-term low-grade inflammation is positively correlated with many diseases, such as cancer, metabolic disorders, and cardiovascular diseases. Due to common anti-inflammatory drugs are suitable for treating acute inflammation and cause severe adverse effects, new safe and effective drug candidates are urgently needed for treating chronic inflammation. Plants of the Asteraceae family have been widely used in traditional medicines for relieving fever symptoms and killing pathogens. The anti-inflammatory properties of sesquiterpenoids from plants in the Asteraceae family have attracted increasing attention in recent decades because of their structural complexity and potent bioactivities. Herein, we provide a comprehensive and up-to-date summary of sesquiterpenoids from the Asteraceae family with anti-inflammatory properties, including their drug likeness and druggability, as analyzed with the SwissADME and ADMETlab online tools. In the future, some sesquiterpenoids might serve as therapeutic agents to treat inflammation-associated diseases. |
| first_indexed | 2024-03-11T18:58:39Z |
| format | Article |
| id | doaj.art-a4acbb916cd24bbfa4a071fee42f940c |
| institution | Directory Open Access Journal |
| issn | 2737-7946 |
| language | English |
| last_indexed | 2024-03-11T18:58:39Z |
| publishDate | 2023-09-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Acta Materia Medica |
| spelling | doaj.art-a4acbb916cd24bbfa4a071fee42f940c2023-10-10T13:47:20ZengCompuscript LtdActa Materia Medica2737-79462023-09-012335737610.15212/AMM-2023-0026Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a reviewCheng Chen0Zheling Feng1Jovana Petrović2Marina Soković3Yang Ye4Ligen Lin5State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, ChinaChina-Serbia “Belt and Road” Joint Laboratory for Natural Products and Drug Discovery, Institute for biological research “Siniša Stanković”, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, SerbiaChina-Serbia “Belt and Road” Joint Laboratory for Natural Products and Drug Discovery, Institute for biological research “Siniša Stanković”, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, SerbiaState Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, ChinaInflammation is an essential part of the immune response to injury and infection. Emerging evidence indicates that long-term low-grade inflammation is positively correlated with many diseases, such as cancer, metabolic disorders, and cardiovascular diseases. Due to common anti-inflammatory drugs are suitable for treating acute inflammation and cause severe adverse effects, new safe and effective drug candidates are urgently needed for treating chronic inflammation. Plants of the Asteraceae family have been widely used in traditional medicines for relieving fever symptoms and killing pathogens. The anti-inflammatory properties of sesquiterpenoids from plants in the Asteraceae family have attracted increasing attention in recent decades because of their structural complexity and potent bioactivities. Herein, we provide a comprehensive and up-to-date summary of sesquiterpenoids from the Asteraceae family with anti-inflammatory properties, including their drug likeness and druggability, as analyzed with the SwissADME and ADMETlab online tools. In the future, some sesquiterpenoids might serve as therapeutic agents to treat inflammation-associated diseases.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0026asteraceaesesquiterpenoidsanti-inflammationdrug-likenessswissadmeadmetlab |
| spellingShingle | Cheng Chen Zheling Feng Jovana Petrović Marina Soković Yang Ye Ligen Lin Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a review Acta Materia Medica asteraceae sesquiterpenoids anti-inflammation drug-likeness swissadme admetlab |
| title | Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a review |
| title_full | Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a review |
| title_fullStr | Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a review |
| title_full_unstemmed | Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a review |
| title_short | Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a review |
| title_sort | sesquiterpenoids from the sunflower family as potential anti inflammatory candidates a review |
| topic | asteraceae sesquiterpenoids anti-inflammation drug-likeness swissadme admetlab |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0026 |
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