Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer
Abstract Background Ovarian cancer is a common cancer type in women and is often associated with onset of malnutrition. Total parenteral nutrition (TPN) is a nutritional intervention method that has been reported to have controversial effect on cancer patients. In the present retrospective study, we...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-021-08537-6 |
| _version_ | 1818678220617154560 |
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| author | Xin Yan Sanyuan Zhang Junmei Jia Jiaolin Yang Yilai Song Haoran Duan |
| author_facet | Xin Yan Sanyuan Zhang Junmei Jia Jiaolin Yang Yilai Song Haoran Duan |
| author_sort | Xin Yan |
| collection | DOAJ |
| description | Abstract Background Ovarian cancer is a common cancer type in women and is often associated with onset of malnutrition. Total parenteral nutrition (TPN) is a nutritional intervention method that has been reported to have controversial effect on cancer patients. In the present retrospective study, we sought to explore the prevalence of malnutrition assessed by the Nutritional Risk Index (NRI) and its association with survival in advanced stage ovarian cancer patients. We also compared the post-operative outcome of the malnourished patients treated with either TPN or conservative management. Results A total of 415 patients with advanced stage ovarian cancer were separated into 4 nutrition groups based on the NRI scores. We found that a number of factors were significantly different among the 4 nutrition groups, including age, serum albumin level, BMI and NRI; among which serum albumin level and NRI were identified to be independent predictors of progression-free and overall survival. In the moderately and severely malnourished patients, those who were treated with TPN had significantly shorter hospitalization period, lower serum albumin level and lower BMI after surgery. In addition, serum albumin level, use of TPN and number of patients with complications were closely related to the hospital stay duration. Conclusion Malnutrition status is closely associated with survival of advanced stage ovarian cancer patients. These patients may benefit from TPN treatment for reduced hospitalization, especially with the onset of hypoalbuminemia. |
| first_indexed | 2024-12-17T09:11:48Z |
| format | Article |
| id | doaj.art-a4ae67c0b7574064a5ef691c7967846a |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-17T09:11:48Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-a4ae67c0b7574064a5ef691c7967846a2022-12-21T21:55:10ZengBMCBMC Cancer1471-24072021-07-012111810.1186/s12885-021-08537-6Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancerXin Yan0Sanyuan Zhang1Junmei Jia2Jiaolin Yang3Yilai Song4Haoran Duan5Department of Drug Clinical Trial, First Hospital of Shanxi Medical UniversityDepartment of Gynecology, First Hospital of Shanxi Medical UniversityDepartment of Oncology, First Hospital of Shanxi Medical UniversityDepartment of Gynecology, First Hospital of Shanxi Medical UniversityDepartment of Drug Clinical Trial, First Hospital of Shanxi Medical UniversitySchool of Nursing, Shanxi Medical UniversityAbstract Background Ovarian cancer is a common cancer type in women and is often associated with onset of malnutrition. Total parenteral nutrition (TPN) is a nutritional intervention method that has been reported to have controversial effect on cancer patients. In the present retrospective study, we sought to explore the prevalence of malnutrition assessed by the Nutritional Risk Index (NRI) and its association with survival in advanced stage ovarian cancer patients. We also compared the post-operative outcome of the malnourished patients treated with either TPN or conservative management. Results A total of 415 patients with advanced stage ovarian cancer were separated into 4 nutrition groups based on the NRI scores. We found that a number of factors were significantly different among the 4 nutrition groups, including age, serum albumin level, BMI and NRI; among which serum albumin level and NRI were identified to be independent predictors of progression-free and overall survival. In the moderately and severely malnourished patients, those who were treated with TPN had significantly shorter hospitalization period, lower serum albumin level and lower BMI after surgery. In addition, serum albumin level, use of TPN and number of patients with complications were closely related to the hospital stay duration. Conclusion Malnutrition status is closely associated with survival of advanced stage ovarian cancer patients. These patients may benefit from TPN treatment for reduced hospitalization, especially with the onset of hypoalbuminemia.https://doi.org/10.1186/s12885-021-08537-6MalnutritionTotal parenteral nutritionOvarian cancerNutritional risk indexSurvival |
| spellingShingle | Xin Yan Sanyuan Zhang Junmei Jia Jiaolin Yang Yilai Song Haoran Duan Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer BMC Cancer Malnutrition Total parenteral nutrition Ovarian cancer Nutritional risk index Survival |
| title | Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer |
| title_full | Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer |
| title_fullStr | Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer |
| title_full_unstemmed | Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer |
| title_short | Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer |
| title_sort | exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer |
| topic | Malnutrition Total parenteral nutrition Ovarian cancer Nutritional risk index Survival |
| url | https://doi.org/10.1186/s12885-021-08537-6 |
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