A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo

A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo

Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting annually in ~219,000 deaths and a societal cost of ~USD 60 billion, and no antivirals or vaccines are available. Here, we assess the anti-norovirus activity of new peptidomimetic aldehydes related to the protease...

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Bibliographic Details
Main Authors: Jana Van Dycke, Wenhao Dai, Zoe Stylianidou, Jian Li, Arno Cuvry, Emma Roux, Bingqian Li, Jasper Rymenants, Lindsey Bervoets, Peter de Witte, Hong Liu, Johan Neyts, Joana Rocha-Pereira
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Viruses
Subjects:
Caliciviridae
antivirals
small molecule
danio rerio
infection
Online Access:https://www.mdpi.com/1999-4915/13/9/1852

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