The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle
The concepts of Ludwik Fleck (1896–1961), a microbiologist, historian, and philosopher of medicine, can be used to analyze the conservative nature of scientific ideas. This is discussed and applied to ideas dominant in the understanding of the eukaryotic cell cycle. These are (a) the G1-phase restri...
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| Format: | Article |
| Language: | English |
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Polish Academy of Arts and Sciences
2017-12-01
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| Series: | Studia Historiae Scientiarum |
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| Online Access: | http://www.ejournals.eu/sj/index.php/SHS/article/view/SHS.17.013.7714/6778 |
| _version_ | 1797699668438679552 |
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| author | Stephen Cooper |
| author_facet | Stephen Cooper |
| author_sort | Stephen Cooper |
| collection | DOAJ |
| description | The concepts of Ludwik Fleck (1896–1961), a microbiologist, historian, and philosopher of medicine, can be used to analyze the conservative nature of scientific ideas. This is discussed and applied to ideas dominant in the understanding of the eukaryotic cell cycle. These are (a) the G1-phase restriction point as a regulatory element of the mammalian cell cycle, (b) the Rate Change Point proposed to exist in fission yeast, and (c) the proposal that a large number of genes are expressed in a cell-cycle-dependent manner.
Fleck proposed that scientific ideas become fixed and difficult to change because criticisms of current and dominant models are either ignored or turned to support of the current model. The idea of a thought-collective leading to the stability of scientific ideas is a central theme of the theory of Ludwik Fleck. |
| first_indexed | 2024-03-12T04:11:08Z |
| format | Article |
| id | doaj.art-a4b1eefeb73f46bfaa6f571bc867648b |
| institution | Directory Open Access Journal |
| issn | 2451-3202 2543-702X |
| language | English |
| last_indexed | 2024-03-12T04:11:08Z |
| publishDate | 2017-12-01 |
| publisher | Polish Academy of Arts and Sciences |
| record_format | Article |
| series | Studia Historiae Scientiarum |
| spelling | doaj.art-a4b1eefeb73f46bfaa6f571bc867648b2023-09-03T11:02:31ZengPolish Academy of Arts and SciencesStudia Historiae Scientiarum2451-32022543-702X2017-12-011633536410.4467/2543702XSHS.17.013.7714The concepts of Ludwik Fleck and their application to the eukaryotic cell cycleStephen Cooper0Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor Michigan, The Center for Cell Cycle Analysis, Longboat Key, Florida (United States)The concepts of Ludwik Fleck (1896–1961), a microbiologist, historian, and philosopher of medicine, can be used to analyze the conservative nature of scientific ideas. This is discussed and applied to ideas dominant in the understanding of the eukaryotic cell cycle. These are (a) the G1-phase restriction point as a regulatory element of the mammalian cell cycle, (b) the Rate Change Point proposed to exist in fission yeast, and (c) the proposal that a large number of genes are expressed in a cell-cycle-dependent manner. Fleck proposed that scientific ideas become fixed and difficult to change because criticisms of current and dominant models are either ignored or turned to support of the current model. The idea of a thought-collective leading to the stability of scientific ideas is a central theme of the theory of Ludwik Fleck.http://www.ejournals.eu/sj/index.php/SHS/article/view/SHS.17.013.7714/6778Ludwik FleckG0G1Restriction PointRate-Change PointEukaryotic Cell CycleGene Expression in Cell Cycle |
| spellingShingle | Stephen Cooper The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle Studia Historiae Scientiarum Ludwik Fleck G0 G1 Restriction Point Rate-Change Point Eukaryotic Cell Cycle Gene Expression in Cell Cycle |
| title | The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle |
| title_full | The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle |
| title_fullStr | The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle |
| title_full_unstemmed | The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle |
| title_short | The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle |
| title_sort | concepts of ludwik fleck and their application to the eukaryotic cell cycle |
| topic | Ludwik Fleck G0 G1 Restriction Point Rate-Change Point Eukaryotic Cell Cycle Gene Expression in Cell Cycle |
| url | http://www.ejournals.eu/sj/index.php/SHS/article/view/SHS.17.013.7714/6778 |
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