Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-<i>N</i>1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-<i>N</i>1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the <i>N</i>1-ribosylated, Ca<sup>2+</sup>-mobilizing, second me...

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Bibliographic Details
Main Authors: Joanna M. Watt, Richard Graeff, Barry V. L. Potter
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
synthesis
cADPR
cyclase
nucleotide
fragment
Online Access:https://www.mdpi.com/1420-3049/26/23/7165

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