Reduced Toxicity of Trichothecenes, Isotrichodermol, and Deoxynivalenol, by Transgenic Expression of the <i>Tri101</i> 3-<i>O</i>-Acetyltransferase Gene in Cultured Mammalian FM3A Cells

Reduced Toxicity of Trichothecenes, Isotrichodermol, and Deoxynivalenol, by Transgenic Expression of the <i>Tri101</i> 3-<i>O</i>-Acetyltransferase Gene in Cultured Mammalian FM3A Cells

In trichothecene-producing fusaria, isotrichodermol (ITDol) is the first intermediate with a trichothecene skeleton. In the biosynthetic pathway of trichothecene, a 3-<i>O</i>-acetyltransferase, encoded by <i>Tri101</i>, acetylates ITDol to a less-toxic intermediate, isotrich...

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Bibliographic Details
Main Authors: Nozomu Tanaka, Ryo Takushima, Akira Tanaka, Ayaki Okada, Kosuke Matsui, Kazuyuki Maeda, Shunichi Aikawa, Makoto Kimura, Naoko Takahashi-Ando
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Toxins
Subjects:
trichothecene
biosynthetic pathway
acetyltransferase
deacetylase
deoxynivalenol
3-acetyldeoxynivalenol
isotrichodermol
isotrichodermin
Online Access:https://www.mdpi.com/2072-6651/11/11/654

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