Glucotoxicity Activation of IL6 and IL11 and Subsequent Induction of Fibrosis May Be Involved in the Pathogenesis of Islet Dysfunction

Glucotoxicity Activation of IL6 and IL11 and Subsequent Induction of Fibrosis May Be Involved in the Pathogenesis of Islet Dysfunction

Background: Islet dysfunction is the main pathological process of type 2 diabetes mellitus (T2DM). Fibrosis causes islet dysfunction, but the current mechanism is still unclear. Here, bioinformatics analysis identified gene clusters closely related to T2DM and differentially expressed genes related...

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Bibliographic Details
Main Authors: Liqin Lu, Lili Zhuang, Ximei Shen, Liyong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
T2DM
islet dysfunction
WGCNA
IL6
IL11
glycotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.708127/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.708127/full

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