Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice
Nonalcoholic fatty liver disease (NAFLD), often associated with obesity, is becoming one of the most common liver diseases worldwide. It is estimated to affect one billion individuals and may be present in approximately 25% of the population globally. NAFLD is viewed as a hepatic manifestation of me...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222010496 |
| _version_ | 1798031025457070080 |
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| author | Gabriela V. Moreira Layanne C.C. Araujo Gilson M. Murata Sandro L. Matos Carla R.O. Carvalho |
| author_facet | Gabriela V. Moreira Layanne C.C. Araujo Gilson M. Murata Sandro L. Matos Carla R.O. Carvalho |
| author_sort | Gabriela V. Moreira |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD), often associated with obesity, is becoming one of the most common liver diseases worldwide. It is estimated to affect one billion individuals and may be present in approximately 25% of the population globally. NAFLD is viewed as a hepatic manifestation of metabolic syndrome, with humans and animal models presenting dyslipidemia, hypertension, and diabetes. The gut-liver axis has been considered the main pathogenesis branch for NAFLD development. Considering that foods or beverages could modulate the gastrointestinal tract, immune system, energy homeostasis regulation, and even the gut-liver axis, we conducted an exploratory study to analyze the effects of kombucha probiotic on hepatic steatosis, glucose tolerance, and hepatic enzymes involved in carbohydrate and fat metabolism using a pre-clinical model. The diet-induced obese mice presented glucose intolerance, hyperinsulinemia, hepatic steatosis, increased collagen fiber deposition in liver vascular spaces, and upregulated TNF-alpha and SREBP-1 gene expression. Mice receiving the kombucha supplement displayed improved glucose tolerance, reduced hyperinsulinemia, decreased citrate synthase and phosphofructokinase-1 enzyme activities, downregulated G-protein-coupled bile acid receptor, also known as TGR5, and farnesol X receptor gene expression, and attenuated steatosis and hepatic collagen fiber deposition. The improvement in glucose tolerance was accompanied by the recovery of acute insulin-induced liver AKT serine phosphorylation. Thus, it is possible to conclude that this probiotic drink has a beneficial effect in reducing the metabolic alterations associated with diet-induced obesity. This probiotic beverage deserves an extension of studies to confirm or refute its potentially beneficial effects. |
| first_indexed | 2024-04-11T19:49:32Z |
| format | Article |
| id | doaj.art-a4b447dba6ef4531b00e7b91aa4fe133 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T19:49:32Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-a4b447dba6ef4531b00e7b91aa4fe1332022-12-22T04:06:21ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-11-01155113660Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese miceGabriela V. Moreira0Layanne C.C. Araujo1Gilson M. Murata2Sandro L. Matos3Carla R.O. Carvalho4University of São Paulo, Department of Physiology and Biophysics, Institute of Biological Science, São Paulo 05508-900, BrazilUniversity of São Paulo, Department of Physiology and Biophysics, Institute of Biological Science, São Paulo 05508-900, BrazilUniversity of São Paulo, Department of Medicine, School of Medicine, São Paulo 01246-903, BrazilUniversity of São Paulo, Department of Physiology and Biophysics, Institute of Biological Science, São Paulo 05508-900, BrazilUniversity of São Paulo, Department of Physiology and Biophysics, Institute of Biological Science, São Paulo 05508-900, Brazil; Corresponding author.Nonalcoholic fatty liver disease (NAFLD), often associated with obesity, is becoming one of the most common liver diseases worldwide. It is estimated to affect one billion individuals and may be present in approximately 25% of the population globally. NAFLD is viewed as a hepatic manifestation of metabolic syndrome, with humans and animal models presenting dyslipidemia, hypertension, and diabetes. The gut-liver axis has been considered the main pathogenesis branch for NAFLD development. Considering that foods or beverages could modulate the gastrointestinal tract, immune system, energy homeostasis regulation, and even the gut-liver axis, we conducted an exploratory study to analyze the effects of kombucha probiotic on hepatic steatosis, glucose tolerance, and hepatic enzymes involved in carbohydrate and fat metabolism using a pre-clinical model. The diet-induced obese mice presented glucose intolerance, hyperinsulinemia, hepatic steatosis, increased collagen fiber deposition in liver vascular spaces, and upregulated TNF-alpha and SREBP-1 gene expression. Mice receiving the kombucha supplement displayed improved glucose tolerance, reduced hyperinsulinemia, decreased citrate synthase and phosphofructokinase-1 enzyme activities, downregulated G-protein-coupled bile acid receptor, also known as TGR5, and farnesol X receptor gene expression, and attenuated steatosis and hepatic collagen fiber deposition. The improvement in glucose tolerance was accompanied by the recovery of acute insulin-induced liver AKT serine phosphorylation. Thus, it is possible to conclude that this probiotic drink has a beneficial effect in reducing the metabolic alterations associated with diet-induced obesity. This probiotic beverage deserves an extension of studies to confirm or refute its potentially beneficial effects.http://www.sciencedirect.com/science/article/pii/S0753332222010496NAFLDIntestinal microbiotaHepatic steatosisInsulin resistanceProbiotic |
| spellingShingle | Gabriela V. Moreira Layanne C.C. Araujo Gilson M. Murata Sandro L. Matos Carla R.O. Carvalho Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice Biomedicine & Pharmacotherapy NAFLD Intestinal microbiota Hepatic steatosis Insulin resistance Probiotic |
| title | Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice |
| title_full | Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice |
| title_fullStr | Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice |
| title_full_unstemmed | Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice |
| title_short | Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice |
| title_sort | kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice |
| topic | NAFLD Intestinal microbiota Hepatic steatosis Insulin resistance Probiotic |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222010496 |
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