The Effects of Histological Grade Ratio on The Progression of High-Grade Non-Muscle Invasive Bladder Tumors
Aim:Histopathological classification is one of the main prognostic factors for non-muscle invasive bladder tumors (NMIBT). We evaluated the relationship between tumor progression and the ratio of high-grade differentiation plus other routine pathological parameters in NMIBT.Materials and Methods:Nin...
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| Format: | Article |
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Galenos Yayincilik
2020-08-01
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| Series: | Namık Kemal Tıp Dergisi |
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http://namikkemalmedj.com/archives/archive-detail/article-preview/the-effects-of-histological-grade-ratio-on-the-pro/40333
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| author | Meltem ÖZNUR Murat AKGÜL Ayşegül İSAL ARSLAN Cenk Murat YAZICI Enes ALTIN |
| author_facet | Meltem ÖZNUR Murat AKGÜL Ayşegül İSAL ARSLAN Cenk Murat YAZICI Enes ALTIN |
| author_sort | Meltem ÖZNUR |
| collection | DOAJ |
| description | Aim:Histopathological classification is one of the main prognostic factors for non-muscle invasive bladder tumors (NMIBT). We evaluated the relationship between tumor progression and the ratio of high-grade differentiation plus other routine pathological parameters in NMIBT.Materials and Methods:Ninety-two patients diagnosed with high grade NIMBT were analyzed between 2010-2018. Demographic information, tumor size, localization, multicentricity, and recurrence/progression situation were evaluated retrospectively. The high/low grade percentage ratio of tumor cells, tumor stage, differentiation, necrosis, lamina-propria invasion, lymphovascular invasion, and carcinoma in-situ presence were also examined by two uro-pathologist. The effect on tumor progression was evaluated with pathological findings.Results:Seventy-four (80.4%) of the patients were reported as T1 and 18 (19.6%) as Ta. The mean ratio of high-grade findings was 11.9±8.5% and 69.5±28.1% for Ta and T1 patients, respectively(p<0.001). Three levels for classification of high degree ratio were determined as 25%, 50% and 75%. The number of patients with high degree ratio >25%, >50% and >75% was found to be 67(72.8%), 54(58.7%) and 43(46.7%), respectively. The high-grade ratio for >25% was in only 1 Ta patient while it was in 66 of the T1 patients(p<0.001). Forty-three patients (58.1%) in the T1 group were found to have a high-grade ratio >75%(p<0.001). Rate of progression was statistically higher in T1 patients with high-grade ratio greater than >50%(p=0.025).Conclusion:When evaluating the nuclear grade, defining tumors solely as high-grade leads to stratifying a highly heterogeneous population in a single group. Higher rate of progression is observed in NIMBT patients with high-grade ratio >50%. |
| first_indexed | 2024-04-10T11:59:18Z |
| format | Article |
| id | doaj.art-a4b53fd7fb974c81a0f656341171d1f7 |
| institution | Directory Open Access Journal |
| issn | 2587-0262 |
| language | English |
| last_indexed | 2024-04-10T11:59:18Z |
| publishDate | 2020-08-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Namık Kemal Tıp Dergisi |
| spelling | doaj.art-a4b53fd7fb974c81a0f656341171d1f72023-02-15T16:16:41ZengGalenos YayincilikNamık Kemal Tıp Dergisi2587-02622020-08-018227127810.37696/nkmj.73016113049054The Effects of Histological Grade Ratio on The Progression of High-Grade Non-Muscle Invasive Bladder TumorsMeltem ÖZNUR0Murat AKGÜL1Ayşegül İSAL ARSLAN2Cenk Murat YAZICI3Enes ALTIN4 Tekirdağ Namık Kemal University Faculty of Medicine, Pathology Department, Tekirdag, TURKEY Tekirdağ Namık Kemal University Faculty of Medicine, Urology Department, Tekirdag, TURKEY Tekirdağ Namık Kemal University Faculty of Medicine, Pathology Department, Tekirdag, TURKEY Tekirdağ Namık Kemal University Faculty of Medicine, Urology Department, Tekirdag, TURKEY Tekirdağ Namık Kemal University Faculty of Medicine, Urology Department, Tekirdag, TURKEY Aim:Histopathological classification is one of the main prognostic factors for non-muscle invasive bladder tumors (NMIBT). We evaluated the relationship between tumor progression and the ratio of high-grade differentiation plus other routine pathological parameters in NMIBT.Materials and Methods:Ninety-two patients diagnosed with high grade NIMBT were analyzed between 2010-2018. Demographic information, tumor size, localization, multicentricity, and recurrence/progression situation were evaluated retrospectively. The high/low grade percentage ratio of tumor cells, tumor stage, differentiation, necrosis, lamina-propria invasion, lymphovascular invasion, and carcinoma in-situ presence were also examined by two uro-pathologist. The effect on tumor progression was evaluated with pathological findings.Results:Seventy-four (80.4%) of the patients were reported as T1 and 18 (19.6%) as Ta. The mean ratio of high-grade findings was 11.9±8.5% and 69.5±28.1% for Ta and T1 patients, respectively(p<0.001). Three levels for classification of high degree ratio were determined as 25%, 50% and 75%. The number of patients with high degree ratio >25%, >50% and >75% was found to be 67(72.8%), 54(58.7%) and 43(46.7%), respectively. The high-grade ratio for >25% was in only 1 Ta patient while it was in 66 of the T1 patients(p<0.001). Forty-three patients (58.1%) in the T1 group were found to have a high-grade ratio >75%(p<0.001). Rate of progression was statistically higher in T1 patients with high-grade ratio greater than >50%(p=0.025).Conclusion:When evaluating the nuclear grade, defining tumors solely as high-grade leads to stratifying a highly heterogeneous population in a single group. Higher rate of progression is observed in NIMBT patients with high-grade ratio >50%. http://namikkemalmedj.com/archives/archive-detail/article-preview/the-effects-of-histological-grade-ratio-on-the-pro/40333 bladderurothelial carcinomahigh-gradeprogressiontransurethral resection |
| spellingShingle | Meltem ÖZNUR Murat AKGÜL Ayşegül İSAL ARSLAN Cenk Murat YAZICI Enes ALTIN The Effects of Histological Grade Ratio on The Progression of High-Grade Non-Muscle Invasive Bladder Tumors Namık Kemal Tıp Dergisi bladder urothelial carcinoma high-grade progression transurethral resection |
| title | The Effects of Histological Grade Ratio on The Progression of High-Grade Non-Muscle Invasive Bladder Tumors |
| title_full | The Effects of Histological Grade Ratio on The Progression of High-Grade Non-Muscle Invasive Bladder Tumors |
| title_fullStr | The Effects of Histological Grade Ratio on The Progression of High-Grade Non-Muscle Invasive Bladder Tumors |
| title_full_unstemmed | The Effects of Histological Grade Ratio on The Progression of High-Grade Non-Muscle Invasive Bladder Tumors |
| title_short | The Effects of Histological Grade Ratio on The Progression of High-Grade Non-Muscle Invasive Bladder Tumors |
| title_sort | effects of histological grade ratio on the progression of high grade non muscle invasive bladder tumors |
| topic | bladder urothelial carcinoma high-grade progression transurethral resection |
| url |
http://namikkemalmedj.com/archives/archive-detail/article-preview/the-effects-of-histological-grade-ratio-on-the-pro/40333
|
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