MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION
Composite preparation of tumor necrosis factor alpha and rheopolyglukin and polyethylene glycol (TNF-α+PG+PEG) was obtained. The specific activity of the samples was 4,13 х 107 IU/mg. The cytolytic activity of drugs TNF-α+PG+PEG and rhTNF-α did not change after 4 months when stored at 6 °С. Preparat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2012-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/931 |
| _version_ | 1797237703783219200 |
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| author | S. G. Gamaley A. V. Bateneva Z. F. Urmantseva G. M. Sisoyeva Ya. V. Markus E. D. Danilenko V. K. Mikhaylova E. A. Volosnikova G. M. Levagina V. I. Masicheva |
| author_facet | S. G. Gamaley A. V. Bateneva Z. F. Urmantseva G. M. Sisoyeva Ya. V. Markus E. D. Danilenko V. K. Mikhaylova E. A. Volosnikova G. M. Levagina V. I. Masicheva |
| author_sort | S. G. Gamaley |
| collection | DOAJ |
| description | Composite preparation of tumor necrosis factor alpha and rheopolyglukin and polyethylene glycol (TNF-α+PG+PEG) was obtained. The specific activity of the samples was 4,13 х 107 IU/mg. The cytolytic activity of drugs TNF-α+PG+PEG and rhTNF-α did not change after 4 months when stored at 6 °С. Preparation TNF-α+PG+PEG provided a moderately prolonged elevation of TNF-alpha in blood of laboratory mice in contrast to TNF-α when they applied to the skin. The composite preparation did not have toxic, allergic and locally irritating action in experiments on laboratory animals. |
| first_indexed | 2024-03-08T12:23:23Z |
| format | Article |
| id | doaj.art-a4b553a9be424c77aef48066059e5cb1 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:23:58Z |
| publishDate | 2012-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-a4b553a9be424c77aef48066059e5cb12024-03-28T07:49:04ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-05-0103(2)264266877MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATIONS. G. Gamaley0A. V. Bateneva1Z. F. Urmantseva2G. M. Sisoyeva3Ya. V. Markus4E. D. Danilenko5V. K. Mikhaylova6E. A. Volosnikova7G. M. Levagina8V. I. Masicheva9Institute of Medical Biotechnology of State Scientific Center of virology and biotechnology “Vektor”Institute of Medical Biotechnology of State Scientific Center of virology and biotechnology “Vektor”Institute of Medical Biotechnology of State Scientific Center of virology and biotechnology “Vektor”Institute of Medical Biotechnology of State Scientific Center of virology and biotechnology “Vektor”Institute of Medical Biotechnology of State Scientific Center of virology and biotechnology “Vektor”Institute of Medical Biotechnology of State Scientific Center of virology and biotechnology “Vektor”Institute of Medical Biotechnology of State Scientific Center of virology and biotechnology “Vektor”Institute of Medical Biotechnology of State Scientific Center of virology and biotechnology “Vektor”Institute of Medical Biotechnology of State Scientific Center of virology and biotechnology “Vektor”Institute of Medical Biotechnology of State Scientific Center of virology and biotechnology “Vektor”Composite preparation of tumor necrosis factor alpha and rheopolyglukin and polyethylene glycol (TNF-α+PG+PEG) was obtained. The specific activity of the samples was 4,13 х 107 IU/mg. The cytolytic activity of drugs TNF-α+PG+PEG and rhTNF-α did not change after 4 months when stored at 6 °С. Preparation TNF-α+PG+PEG provided a moderately prolonged elevation of TNF-alpha in blood of laboratory mice in contrast to TNF-α when they applied to the skin. The composite preparation did not have toxic, allergic and locally irritating action in experiments on laboratory animals.https://www.actabiomedica.ru/jour/article/view/931tumor necrosis factor alphatnf-αrheopolyglukinpolyethylene glycol |
| spellingShingle | S. G. Gamaley A. V. Bateneva Z. F. Urmantseva G. M. Sisoyeva Ya. V. Markus E. D. Danilenko V. K. Mikhaylova E. A. Volosnikova G. M. Levagina V. I. Masicheva MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION Acta Biomedica Scientifica tumor necrosis factor alpha tnf-α rheopolyglukin polyethylene glycol |
| title | MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION |
| title_full | MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION |
| title_fullStr | MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION |
| title_full_unstemmed | MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION |
| title_short | MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION |
| title_sort | medicinal form of tnf α for local administration |
| topic | tumor necrosis factor alpha tnf-α rheopolyglukin polyethylene glycol |
| url | https://www.actabiomedica.ru/jour/article/view/931 |
| work_keys_str_mv | AT sggamaley medicinalformoftnfaforlocaladministration AT avbateneva medicinalformoftnfaforlocaladministration AT zfurmantseva medicinalformoftnfaforlocaladministration AT gmsisoyeva medicinalformoftnfaforlocaladministration AT yavmarkus medicinalformoftnfaforlocaladministration AT eddanilenko medicinalformoftnfaforlocaladministration AT vkmikhaylova medicinalformoftnfaforlocaladministration AT eavolosnikova medicinalformoftnfaforlocaladministration AT gmlevagina medicinalformoftnfaforlocaladministration AT vimasicheva medicinalformoftnfaforlocaladministration |