A diversified role for γδT cells in vector-borne diseases
Vector-borne diseases have high morbidity and mortality and are major health threats worldwide. γδT cells represent a small but essential subpopulation of T cells. They reside in most human tissues and exert important functions in both natural and adaptive immune responses. Emerging evidence have sh...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.965503/full |
| _version_ | 1798040067291217920 |
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| author | Chen Chen Aibao Chen Yanan Yang |
| author_facet | Chen Chen Aibao Chen Yanan Yang |
| author_sort | Chen Chen |
| collection | DOAJ |
| description | Vector-borne diseases have high morbidity and mortality and are major health threats worldwide. γδT cells represent a small but essential subpopulation of T cells. They reside in most human tissues and exert important functions in both natural and adaptive immune responses. Emerging evidence have shown that the activation and expansion of γδT cells invoked by pathogens play a diversified role in the regulation of host-pathogen interactions and disease progression. A better understanding of such a role for γδT cells may contribute significantly to developing novel preventative and therapeutic strategies. Herein, we summarize recent exciting findings in the field, with a focus on the role of γδT cells in the infection of vector-borne pathogens. |
| first_indexed | 2024-04-11T22:02:23Z |
| format | Article |
| id | doaj.art-a4b69036564746abbe70f1d9f02c3e0c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T22:02:23Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a4b69036564746abbe70f1d9f02c3e0c2022-12-22T04:00:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.965503965503A diversified role for γδT cells in vector-borne diseasesChen Chen0Aibao Chen1Yanan Yang2Department of Microbiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaDepartment of Cell Biology, School of Life Sciences, Anhui Medical University, Hefei, ChinaDepartment of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaVector-borne diseases have high morbidity and mortality and are major health threats worldwide. γδT cells represent a small but essential subpopulation of T cells. They reside in most human tissues and exert important functions in both natural and adaptive immune responses. Emerging evidence have shown that the activation and expansion of γδT cells invoked by pathogens play a diversified role in the regulation of host-pathogen interactions and disease progression. A better understanding of such a role for γδT cells may contribute significantly to developing novel preventative and therapeutic strategies. Herein, we summarize recent exciting findings in the field, with a focus on the role of γδT cells in the infection of vector-borne pathogens.https://www.frontiersin.org/articles/10.3389/fimmu.2022.965503/fullγδT cellsvector-borne diseases (VBDs)host immune responseinfectionpathogens |
| spellingShingle | Chen Chen Aibao Chen Yanan Yang A diversified role for γδT cells in vector-borne diseases Frontiers in Immunology γδT cells vector-borne diseases (VBDs) host immune response infection pathogens |
| title | A diversified role for γδT cells in vector-borne diseases |
| title_full | A diversified role for γδT cells in vector-borne diseases |
| title_fullStr | A diversified role for γδT cells in vector-borne diseases |
| title_full_unstemmed | A diversified role for γδT cells in vector-borne diseases |
| title_short | A diversified role for γδT cells in vector-borne diseases |
| title_sort | diversified role for γδt cells in vector borne diseases |
| topic | γδT cells vector-borne diseases (VBDs) host immune response infection pathogens |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.965503/full |
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