Health benefits and mechanisms of theobromine
This comprehensive review elucidates the potential health benefits of theobromine, the principal psychopharmacological compound abundant in cocoa beans and various other sources. Theobromine showcases neuroprotective attributes, enhances cognitive function, and holds promise in mitigating age-relate...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624001282 |
| _version_ | 1797256431969239040 |
|---|---|
| author | Mengjuan Zhang Haifeng Zhang Lu Jia Yi Zhang Runwen Qin Shihua Xu Yingwu Mei |
| author_facet | Mengjuan Zhang Haifeng Zhang Lu Jia Yi Zhang Runwen Qin Shihua Xu Yingwu Mei |
| author_sort | Mengjuan Zhang |
| collection | DOAJ |
| description | This comprehensive review elucidates the potential health benefits of theobromine, the principal psychopharmacological compound abundant in cocoa beans and various other sources. Theobromine showcases neuroprotective attributes, enhances cognitive function, and holds promise in mitigating age-related cognitive decline and neurodegenerative disorders. Additionally, it exhibits anti-inflammatory properties, facilitates adipocyte browning, and contributes to weight management by augmenting lipid metabolism. Moreover, theobromine displays the potential to prevent kidney stone formation by inhibiting uric acid crystallization and promoting diuresis. As a metabolite of caffeine in mammals, theobromine shares similar pharmacological effects, primarily attributed to its structural resemblance to adenosine. These effects encompass phosphodiesterase inhibition, modulation of poly(ADP-ribose) polymerase 1 activity, and adenosine receptor antagonism. While theobromine shows significant promise for medical applications, further research is imperative to comprehensively understand its clinical efficacy and safety profile. |
| first_indexed | 2024-04-24T22:21:39Z |
| format | Article |
| id | doaj.art-a4b72cbd6fc541b093a532569aac857b |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-24T22:21:39Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-a4b72cbd6fc541b093a532569aac857b2024-03-20T06:09:10ZengElsevierJournal of Functional Foods1756-46462024-04-01115106126Health benefits and mechanisms of theobromineMengjuan Zhang0Haifeng Zhang1Lu Jia2Yi Zhang3Runwen Qin4Shihua Xu5Yingwu Mei6Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Henan 450001, ChinaDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Henan 450001, ChinaDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Henan 450001, ChinaDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Henan 450001, ChinaDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Henan 450001, ChinaDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Henan 450001, ChinaCorresponding author.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Henan 450001, ChinaThis comprehensive review elucidates the potential health benefits of theobromine, the principal psychopharmacological compound abundant in cocoa beans and various other sources. Theobromine showcases neuroprotective attributes, enhances cognitive function, and holds promise in mitigating age-related cognitive decline and neurodegenerative disorders. Additionally, it exhibits anti-inflammatory properties, facilitates adipocyte browning, and contributes to weight management by augmenting lipid metabolism. Moreover, theobromine displays the potential to prevent kidney stone formation by inhibiting uric acid crystallization and promoting diuresis. As a metabolite of caffeine in mammals, theobromine shares similar pharmacological effects, primarily attributed to its structural resemblance to adenosine. These effects encompass phosphodiesterase inhibition, modulation of poly(ADP-ribose) polymerase 1 activity, and adenosine receptor antagonism. While theobromine shows significant promise for medical applications, further research is imperative to comprehensively understand its clinical efficacy and safety profile.http://www.sciencedirect.com/science/article/pii/S1756464624001282TheobromineCognitive modulationImmunityMethylxanthinesAdenosine receptor |
| spellingShingle | Mengjuan Zhang Haifeng Zhang Lu Jia Yi Zhang Runwen Qin Shihua Xu Yingwu Mei Health benefits and mechanisms of theobromine Journal of Functional Foods Theobromine Cognitive modulation Immunity Methylxanthines Adenosine receptor |
| title | Health benefits and mechanisms of theobromine |
| title_full | Health benefits and mechanisms of theobromine |
| title_fullStr | Health benefits and mechanisms of theobromine |
| title_full_unstemmed | Health benefits and mechanisms of theobromine |
| title_short | Health benefits and mechanisms of theobromine |
| title_sort | health benefits and mechanisms of theobromine |
| topic | Theobromine Cognitive modulation Immunity Methylxanthines Adenosine receptor |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624001282 |
| work_keys_str_mv | AT mengjuanzhang healthbenefitsandmechanismsoftheobromine AT haifengzhang healthbenefitsandmechanismsoftheobromine AT lujia healthbenefitsandmechanismsoftheobromine AT yizhang healthbenefitsandmechanismsoftheobromine AT runwenqin healthbenefitsandmechanismsoftheobromine AT shihuaxu healthbenefitsandmechanismsoftheobromine AT yingwumei healthbenefitsandmechanismsoftheobromine |