Glucose Metabolism in Burns—What Happens?
Severe burns represent an important challenge for patients and medical teams. They lead to profound metabolic alterations, trigger a systemic inflammatory response, crush the immune defense, impair the function of the heart, lungs, kidneys, liver, etc. The metabolism is shifted towards a hypermetabo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/10/5159 |
| _version_ | 1797534258794856448 |
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| author | Silviu Constantin Badoiu Daniela Miricescu Iulia-Ioana Stanescu-Spinu Alexandra Ripszky Totan Silvia Elena Badoiu Michel Costagliola Maria Greabu |
| author_facet | Silviu Constantin Badoiu Daniela Miricescu Iulia-Ioana Stanescu-Spinu Alexandra Ripszky Totan Silvia Elena Badoiu Michel Costagliola Maria Greabu |
| author_sort | Silviu Constantin Badoiu |
| collection | DOAJ |
| description | Severe burns represent an important challenge for patients and medical teams. They lead to profound metabolic alterations, trigger a systemic inflammatory response, crush the immune defense, impair the function of the heart, lungs, kidneys, liver, etc. The metabolism is shifted towards a hypermetabolic state, and this situation might persist for years after the burn, having deleterious consequences for the patient’s health. Severely burned patients lack energy substrates and react in order to produce and maintain augmented levels of glucose, which is the fuel “ready to use” by cells. In this paper, we discuss biological substances that induce a hyperglycemic response, concur to insulin resistance, and determine cell disturbance after a severe burn. We also focus on the most effective agents that provide pharmacological modulations of the changes in glucose metabolism. |
| first_indexed | 2024-03-10T11:27:58Z |
| format | Article |
| id | doaj.art-a4b7a46a10724827b06affea2e2c3685 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:27:58Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a4b7a46a10724827b06affea2e2c36852023-11-21T19:32:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012210515910.3390/ijms22105159Glucose Metabolism in Burns—What Happens?Silviu Constantin Badoiu0Daniela Miricescu1Iulia-Ioana Stanescu-Spinu2Alexandra Ripszky Totan3Silvia Elena Badoiu4Michel Costagliola5Maria Greabu6Department of Anatomy and Embryology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, RomaniaDepartment of Biochemistry, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, RomaniaDepartment of Biochemistry, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, RomaniaDepartment of Biochemistry, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, RomaniaDepartment of Plastic and Reconstructive Surgery, Faculté de Médicine Toulouse-Rangueil 3, Université Toulouse III—Paul Sabatier, Rue de Languedoc, CEDEX 04, 31000 Toulouse, FranceDepartment of Biochemistry, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, RomaniaSevere burns represent an important challenge for patients and medical teams. They lead to profound metabolic alterations, trigger a systemic inflammatory response, crush the immune defense, impair the function of the heart, lungs, kidneys, liver, etc. The metabolism is shifted towards a hypermetabolic state, and this situation might persist for years after the burn, having deleterious consequences for the patient’s health. Severely burned patients lack energy substrates and react in order to produce and maintain augmented levels of glucose, which is the fuel “ready to use” by cells. In this paper, we discuss biological substances that induce a hyperglycemic response, concur to insulin resistance, and determine cell disturbance after a severe burn. We also focus on the most effective agents that provide pharmacological modulations of the changes in glucose metabolism.https://www.mdpi.com/1422-0067/22/10/5159glucose metabolismburnshypermetabolic statehyperglycemiainsulin resistance |
| spellingShingle | Silviu Constantin Badoiu Daniela Miricescu Iulia-Ioana Stanescu-Spinu Alexandra Ripszky Totan Silvia Elena Badoiu Michel Costagliola Maria Greabu Glucose Metabolism in Burns—What Happens? International Journal of Molecular Sciences glucose metabolism burns hypermetabolic state hyperglycemia insulin resistance |
| title | Glucose Metabolism in Burns—What Happens? |
| title_full | Glucose Metabolism in Burns—What Happens? |
| title_fullStr | Glucose Metabolism in Burns—What Happens? |
| title_full_unstemmed | Glucose Metabolism in Burns—What Happens? |
| title_short | Glucose Metabolism in Burns—What Happens? |
| title_sort | glucose metabolism in burns what happens |
| topic | glucose metabolism burns hypermetabolic state hyperglycemia insulin resistance |
| url | https://www.mdpi.com/1422-0067/22/10/5159 |
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