Cohort profile: The Western Australian Sleep health study, a prospective sleep clinic cohort study
Genetic and epidemiologic investigations into obstructive sleep apnoea (OSA) have been limited by a scarcity of sizeable well-characterised sleep clinic cohorts with laboratory-based polysomnography (PSG). This profile reports the characteristics of a prospective clinic cohort study exploring the ge...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Sleep Epidemiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266734362100010X |
| _version_ | 1811330596872388608 |
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| author | Bindiya Shenoy Bhajan Singh Satvinder S Dhaliwal Stuart King Siobhan C Rea Ivan T Ling Peter R Eastwood David R Hillman Sutapa Mukherjee Lyle J Palmer Nigel McArdle |
| author_facet | Bindiya Shenoy Bhajan Singh Satvinder S Dhaliwal Stuart King Siobhan C Rea Ivan T Ling Peter R Eastwood David R Hillman Sutapa Mukherjee Lyle J Palmer Nigel McArdle |
| author_sort | Bindiya Shenoy |
| collection | DOAJ |
| description | Genetic and epidemiologic investigations into obstructive sleep apnoea (OSA) have been limited by a scarcity of sizeable well-characterised sleep clinic cohorts with laboratory-based polysomnography (PSG). This profile reports the characteristics of a prospective clinic cohort study exploring the genotypic and phenotypic features of OSA with ongoing patient follow-up to assess long-term health outcomes. The Western Australian Sleep Health Study (WASHS) recruited patients at a large tertiary hospital sleep clinic in Perth, Australia. Between 2006 and 2010, 5948 consecutive new adult patients attended the clinic and 4914 were eligible to participate following consent and screening. Among eligible patients, 98.5% (n = 4839) had diagnostic PSG available, and 86.0% (n = 4226) were comprehensively phenotyped by clinical questionnaire and anthropometric measurements. Among those comprehensively phenotyped, blood biospecimens for biochemistry and DNA were obtained in 2759 (65.2%), and linked health administrative data was requested in 2017 for 4067 patients (96.2%). The group of most interest, the comprehensively phenotyped patients (n = 4226), were predominantly male (60.6%), middle-aged (mean±SD: 50.5 ± 14.0 years), and obese (32.7 ± 7.7 kg/m2). The majority of this group were diagnosed with OSA (93.8%). The WASHS Prospective Sleep Clinic Cohort is amongst the largest OSA cohorts globally with PSG and long-term morbidity and mortality data. Comprehensive phenotype and genotype data have contributed to numerous publications on the epidemiology and genetics of OSA. Patients have been monitored by ongoing clinic review, where OSA treatment data is collected, and by follow-up studies, such as an Australian National Health and Medical Research Council funded project (2018–2021) investigating cardiovascular outcomes in OSA. |
| first_indexed | 2024-04-13T16:04:40Z |
| format | Article |
| id | doaj.art-a4b7ce4838dc4d0d97574998a3ca9f1d |
| institution | Directory Open Access Journal |
| issn | 2667-3436 |
| language | English |
| last_indexed | 2024-04-13T16:04:40Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sleep Epidemiology |
| spelling | doaj.art-a4b7ce4838dc4d0d97574998a3ca9f1d2022-12-22T02:40:25ZengElsevierSleep Epidemiology2667-34362021-12-011100010Cohort profile: The Western Australian Sleep health study, a prospective sleep clinic cohort studyBindiya Shenoy0Bhajan Singh1Satvinder S Dhaliwal2Stuart King3Siobhan C Rea4Ivan T Ling5Peter R Eastwood6David R Hillman7Sutapa Mukherjee8Lyle J Palmer9Nigel McArdle10West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Australia; Centre for Sleep Science, School of Human Sciences, University of Western Australia, Perth, AustraliaWest Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Australia; Centre for Sleep Science, School of Human Sciences, University of Western Australia, Perth, AustraliaCurtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Perth, Australia; Duke-NUS Medical School, National University of Singapore, SingaporeWest Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, AustraliaWest Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, AustraliaWest Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, AustraliaFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, AustraliaWest Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Australia; Centre for Sleep Science, School of Human Sciences, University of Western Australia, Perth, AustraliaAdelaide Institute for Sleep Health, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, AustraliaSchool of Public Health, University of Adelaide, Adelaide, AustraliaWest Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Australia; Centre for Sleep Science, School of Human Sciences, University of Western Australia, Perth, Australia; Corresponding author at: West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia.Genetic and epidemiologic investigations into obstructive sleep apnoea (OSA) have been limited by a scarcity of sizeable well-characterised sleep clinic cohorts with laboratory-based polysomnography (PSG). This profile reports the characteristics of a prospective clinic cohort study exploring the genotypic and phenotypic features of OSA with ongoing patient follow-up to assess long-term health outcomes. The Western Australian Sleep Health Study (WASHS) recruited patients at a large tertiary hospital sleep clinic in Perth, Australia. Between 2006 and 2010, 5948 consecutive new adult patients attended the clinic and 4914 were eligible to participate following consent and screening. Among eligible patients, 98.5% (n = 4839) had diagnostic PSG available, and 86.0% (n = 4226) were comprehensively phenotyped by clinical questionnaire and anthropometric measurements. Among those comprehensively phenotyped, blood biospecimens for biochemistry and DNA were obtained in 2759 (65.2%), and linked health administrative data was requested in 2017 for 4067 patients (96.2%). The group of most interest, the comprehensively phenotyped patients (n = 4226), were predominantly male (60.6%), middle-aged (mean±SD: 50.5 ± 14.0 years), and obese (32.7 ± 7.7 kg/m2). The majority of this group were diagnosed with OSA (93.8%). The WASHS Prospective Sleep Clinic Cohort is amongst the largest OSA cohorts globally with PSG and long-term morbidity and mortality data. Comprehensive phenotype and genotype data have contributed to numerous publications on the epidemiology and genetics of OSA. Patients have been monitored by ongoing clinic review, where OSA treatment data is collected, and by follow-up studies, such as an Australian National Health and Medical Research Council funded project (2018–2021) investigating cardiovascular outcomes in OSA.http://www.sciencedirect.com/science/article/pii/S266734362100010Xepidemiology, polysomnography, sleep, sleep apnoea, sleep-disordered breathing, Western Australian Sleep Health Study, Abbreviations, AASM, American Academy of Sleep MedicineAHI, apnoea-hypopnoea indexArI, arousal indexBMI, body mass indexCAI, central apnoea indexCPAP, continuous positive airway pressure |
| spellingShingle | Bindiya Shenoy Bhajan Singh Satvinder S Dhaliwal Stuart King Siobhan C Rea Ivan T Ling Peter R Eastwood David R Hillman Sutapa Mukherjee Lyle J Palmer Nigel McArdle Cohort profile: The Western Australian Sleep health study, a prospective sleep clinic cohort study Sleep Epidemiology epidemiology, polysomnography, sleep, sleep apnoea, sleep-disordered breathing, Western Australian Sleep Health Study, Abbreviations, AASM, American Academy of Sleep Medicine AHI, apnoea-hypopnoea index ArI, arousal index BMI, body mass index CAI, central apnoea index CPAP, continuous positive airway pressure |
| title | Cohort profile: The Western Australian Sleep health study, a prospective sleep clinic cohort study |
| title_full | Cohort profile: The Western Australian Sleep health study, a prospective sleep clinic cohort study |
| title_fullStr | Cohort profile: The Western Australian Sleep health study, a prospective sleep clinic cohort study |
| title_full_unstemmed | Cohort profile: The Western Australian Sleep health study, a prospective sleep clinic cohort study |
| title_short | Cohort profile: The Western Australian Sleep health study, a prospective sleep clinic cohort study |
| title_sort | cohort profile the western australian sleep health study a prospective sleep clinic cohort study |
| topic | epidemiology, polysomnography, sleep, sleep apnoea, sleep-disordered breathing, Western Australian Sleep Health Study, Abbreviations, AASM, American Academy of Sleep Medicine AHI, apnoea-hypopnoea index ArI, arousal index BMI, body mass index CAI, central apnoea index CPAP, continuous positive airway pressure |
| url | http://www.sciencedirect.com/science/article/pii/S266734362100010X |
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