Structural Analysis of the Simultaneous Activation and Inhibition of γ-Secretase Activity in the Development of Drugs for Alzheimer’s Disease

Structural Analysis of the Simultaneous Activation and Inhibition of γ-Secretase Activity in the Development of Drugs for Alzheimer’s Disease

<b>Significance:</b> The majority of the drugs which target membrane-embedded protease γ-secretase show an unusual biphasic activation–inhibition dose-response in cells, model animals, and humans. Semagacestat and avagacestat are two biphasic drugs that can facilitate cognitive decline i...

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Bibliographic Details
Main Authors:	Željko M. Svedružić, Katarina Vrbnjak, Manuel Martinović, Vedran Miletić
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Pharmaceutics
Subjects:	Alzheimer semagacestat avagacestat molecular dynamics drug-design familial Alzheimer’s disease
Online Access:	https://www.mdpi.com/1999-4923/13/4/514

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