Gold-Polypyrrole-Loaded Eosin in Photo-Mediated Treatment of Hidradenitis Suppurativa: In Vivo Trans-Epidermal Permeation Study and Clinical Case Report
This study reports a new protocol for the management of Hidradenitis Suppurativa (HS), depending on the synergistic photodynamic and photothermal effect of eosin yellow-gold-polypyrrole hybrid nanoparticles (E-G-Ppy NPs). E-G-Ppy NPs and gold-polypyrrole NPs (G-Ppy NPs) were synthesized, characteriz...
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MDPI AG
2022-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/10/2197 |
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| author | Abdullah I. El-Kholy Maha Fadel Maha Nasr Ibrahim El-Sherbiny Abeer Tawfik Yasser O. Mosaad Doaa Abdel Fadeel |
| author_facet | Abdullah I. El-Kholy Maha Fadel Maha Nasr Ibrahim El-Sherbiny Abeer Tawfik Yasser O. Mosaad Doaa Abdel Fadeel |
| author_sort | Abdullah I. El-Kholy |
| collection | DOAJ |
| description | This study reports a new protocol for the management of Hidradenitis Suppurativa (HS), depending on the synergistic photodynamic and photothermal effect of eosin yellow-gold-polypyrrole hybrid nanoparticles (E-G-Ppy NPs). E-G-Ppy NPs and gold-polypyrrole NPs (G-Ppy NPs) were synthesized, characterized, and formulated in topical hydrogels. Then, in vivo trans-epidermal permeation study, under both dark and white light-irradiation conditions, was done on albino mice. The E-G-Ppy hydrogel was then applied on a twenty-four years old female with recurrent axillary HS lesions pretreated with fractional CO<sub>2</sub> laser. Thereafter, the treated lesions were irradiated sequentially, using an IPL system, in the visible (~550 nm) and NIR band (630–1100 nm) to activate the synthesized nanoparticles. Results showed that, upon application to mice skin, E-G-Ppy exhibited good tolerance and safety under dark conditions and induced degenerative changes into dermal layers after white-light activation, reflecting deep penetration. Photo-activation of E-G-Ppy hydrogel to a severe Hidradenitis Suppurativa case showed an improvement of 80% of the lesions according to average HS-LASI scores after 4 sessions with no recurrence during a follow-up period of six months. In summary, the dual photodynamic/photothermal activation of E-G-Ppy NPs can represent a promising modality for management of HS. Further expanded clinical studies may be needed. |
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| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T19:34:53Z |
| publishDate | 2022-10-01 |
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| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a4b80c9496e04b3faf24542cad3d117a2023-11-24T01:58:01ZengMDPI AGPharmaceutics1999-49232022-10-011410219710.3390/pharmaceutics14102197Gold-Polypyrrole-Loaded Eosin in Photo-Mediated Treatment of Hidradenitis Suppurativa: In Vivo Trans-Epidermal Permeation Study and Clinical Case ReportAbdullah I. El-Kholy0Maha Fadel1Maha Nasr2Ibrahim El-Sherbiny3Abeer Tawfik4Yasser O. Mosaad5Doaa Abdel Fadeel6Department of Medical Applications of Laser, Pharmaceutical Nano-Technology Unit, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Giza 12613, EgyptDepartment of Medical Applications of Laser, Pharmaceutical Nano-Technology Unit, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Giza 12613, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, EgyptNanomaterials Lab, Center for Materials Science, Zewail City of Science and Technology, 6th October City, Giza 12578, EgyptDepartment of Medical Applications of Laser, Dermatology Unit, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Giza 12613, EgyptDepartment of Pharmacy Practice and Clinical Pharmacy, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University, Cairo 11835, EgyptDepartment of Medical Applications of Laser, Pharmaceutical Nano-Technology Unit, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Giza 12613, EgyptThis study reports a new protocol for the management of Hidradenitis Suppurativa (HS), depending on the synergistic photodynamic and photothermal effect of eosin yellow-gold-polypyrrole hybrid nanoparticles (E-G-Ppy NPs). E-G-Ppy NPs and gold-polypyrrole NPs (G-Ppy NPs) were synthesized, characterized, and formulated in topical hydrogels. Then, in vivo trans-epidermal permeation study, under both dark and white light-irradiation conditions, was done on albino mice. The E-G-Ppy hydrogel was then applied on a twenty-four years old female with recurrent axillary HS lesions pretreated with fractional CO<sub>2</sub> laser. Thereafter, the treated lesions were irradiated sequentially, using an IPL system, in the visible (~550 nm) and NIR band (630–1100 nm) to activate the synthesized nanoparticles. Results showed that, upon application to mice skin, E-G-Ppy exhibited good tolerance and safety under dark conditions and induced degenerative changes into dermal layers after white-light activation, reflecting deep penetration. Photo-activation of E-G-Ppy hydrogel to a severe Hidradenitis Suppurativa case showed an improvement of 80% of the lesions according to average HS-LASI scores after 4 sessions with no recurrence during a follow-up period of six months. In summary, the dual photodynamic/photothermal activation of E-G-Ppy NPs can represent a promising modality for management of HS. Further expanded clinical studies may be needed.https://www.mdpi.com/1999-4923/14/10/2197polypyrrolegoldeosin yellowphotodynamicphotothermalHidradenitis Suppurativa |
| spellingShingle | Abdullah I. El-Kholy Maha Fadel Maha Nasr Ibrahim El-Sherbiny Abeer Tawfik Yasser O. Mosaad Doaa Abdel Fadeel Gold-Polypyrrole-Loaded Eosin in Photo-Mediated Treatment of Hidradenitis Suppurativa: In Vivo Trans-Epidermal Permeation Study and Clinical Case Report Pharmaceutics polypyrrole gold eosin yellow photodynamic photothermal Hidradenitis Suppurativa |
| title | Gold-Polypyrrole-Loaded Eosin in Photo-Mediated Treatment of Hidradenitis Suppurativa: In Vivo Trans-Epidermal Permeation Study and Clinical Case Report |
| title_full | Gold-Polypyrrole-Loaded Eosin in Photo-Mediated Treatment of Hidradenitis Suppurativa: In Vivo Trans-Epidermal Permeation Study and Clinical Case Report |
| title_fullStr | Gold-Polypyrrole-Loaded Eosin in Photo-Mediated Treatment of Hidradenitis Suppurativa: In Vivo Trans-Epidermal Permeation Study and Clinical Case Report |
| title_full_unstemmed | Gold-Polypyrrole-Loaded Eosin in Photo-Mediated Treatment of Hidradenitis Suppurativa: In Vivo Trans-Epidermal Permeation Study and Clinical Case Report |
| title_short | Gold-Polypyrrole-Loaded Eosin in Photo-Mediated Treatment of Hidradenitis Suppurativa: In Vivo Trans-Epidermal Permeation Study and Clinical Case Report |
| title_sort | gold polypyrrole loaded eosin in photo mediated treatment of hidradenitis suppurativa in vivo trans epidermal permeation study and clinical case report |
| topic | polypyrrole gold eosin yellow photodynamic photothermal Hidradenitis Suppurativa |
| url | https://www.mdpi.com/1999-4923/14/10/2197 |
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