Cytokine and antibody production during murine leptospirosis
The aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising...
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| Format: | Article |
| Language: | English |
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SciELO
2006-01-01
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| Series: | Journal of Venomous Animals and Toxins including Tropical Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000400006 |
| _version_ | 1819274073651281920 |
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| author | M. Marinho C. Silva V. M. F. Lima J. R. Peiró S. H. V. Perri |
| author_facet | M. Marinho C. Silva V. M. F. Lima J. R. Peiró S. H. V. Perri |
| author_sort | M. Marinho |
| collection | DOAJ |
| description | The aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising of both TNF-alpha and IL-6 in the immunopathogenesis of leptospirosis during an experimental infection of BALB/c mice inoculated with Leptospira interrogans serovar Canicola was verified. Results showed higher levels of TNF-alpha and IL-6 in the initial phase of infection, in which the greatest bacterial clearance was observed. However, when the bacterial recovery was compared with the kinetics of the production of antibodies, the results revealed a kinetics proportionally inverted to antibody production. This fact may be related to some inhibitory factor which could be responsible for the selective suppression of the cellular immune response. We concluded that during leptospirosis there was a greater mobilization of the cellular immune response activity, mainly in the initial phase of the infectious process, for posterior involvement of the humoral response, and that both TNF-alpha and IL-6 could be associated with the immunopathogenesis of the disease. |
| first_indexed | 2024-12-23T23:02:38Z |
| format | Article |
| id | doaj.art-a4b8378ec734478ab44b6b2ae202004b |
| institution | Directory Open Access Journal |
| issn | 1678-9199 |
| language | English |
| last_indexed | 2024-12-23T23:02:38Z |
| publishDate | 2006-01-01 |
| publisher | SciELO |
| record_format | Article |
| series | Journal of Venomous Animals and Toxins including Tropical Diseases |
| spelling | doaj.art-a4b8378ec734478ab44b6b2ae202004b2022-12-21T17:26:52ZengSciELOJournal of Venomous Animals and Toxins including Tropical Diseases1678-91992006-01-0112459560310.1590/S1678-91992006000400006Cytokine and antibody production during murine leptospirosisM. MarinhoC. SilvaV. M. F. LimaJ. R. PeiróS. H. V. PerriThe aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising of both TNF-alpha and IL-6 in the immunopathogenesis of leptospirosis during an experimental infection of BALB/c mice inoculated with Leptospira interrogans serovar Canicola was verified. Results showed higher levels of TNF-alpha and IL-6 in the initial phase of infection, in which the greatest bacterial clearance was observed. However, when the bacterial recovery was compared with the kinetics of the production of antibodies, the results revealed a kinetics proportionally inverted to antibody production. This fact may be related to some inhibitory factor which could be responsible for the selective suppression of the cellular immune response. We concluded that during leptospirosis there was a greater mobilization of the cellular immune response activity, mainly in the initial phase of the infectious process, for posterior involvement of the humoral response, and that both TNF-alpha and IL-6 could be associated with the immunopathogenesis of the disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000400006cytokinescellular immune responseBALB/c miceleptospirosis |
| spellingShingle | M. Marinho C. Silva V. M. F. Lima J. R. Peiró S. H. V. Perri Cytokine and antibody production during murine leptospirosis Journal of Venomous Animals and Toxins including Tropical Diseases cytokines cellular immune response BALB/c mice leptospirosis |
| title | Cytokine and antibody production during murine leptospirosis |
| title_full | Cytokine and antibody production during murine leptospirosis |
| title_fullStr | Cytokine and antibody production during murine leptospirosis |
| title_full_unstemmed | Cytokine and antibody production during murine leptospirosis |
| title_short | Cytokine and antibody production during murine leptospirosis |
| title_sort | cytokine and antibody production during murine leptospirosis |
| topic | cytokines cellular immune response BALB/c mice leptospirosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000400006 |
| work_keys_str_mv | AT mmarinho cytokineandantibodyproductionduringmurineleptospirosis AT csilva cytokineandantibodyproductionduringmurineleptospirosis AT vmflima cytokineandantibodyproductionduringmurineleptospirosis AT jrpeiro cytokineandantibodyproductionduringmurineleptospirosis AT shvperri cytokineandantibodyproductionduringmurineleptospirosis |