New Therapeutic Avenues of mCSF for Brain Diseases and Injuries
Macrophage colony-stimulating factor (mCSF) is a cytokine known to promote the recruitment of macrophages inducing the release of CCL2, a chemokine mobilizing monocytes to sites of inflammation. Additionally, it induces microglia/macrophage proliferation and the polarization of these cells towards a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2018.00499/full |
| _version_ | 1828902761555558400 |
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| author | Vincent Pons Serge Rivest |
| author_facet | Vincent Pons Serge Rivest |
| author_sort | Vincent Pons |
| collection | DOAJ |
| description | Macrophage colony-stimulating factor (mCSF) is a cytokine known to promote the recruitment of macrophages inducing the release of CCL2, a chemokine mobilizing monocytes to sites of inflammation. Additionally, it induces microglia/macrophage proliferation and the polarization of these cells towards a M2-like phenotype, impairing their ability to release pro-inflammatory factors and toxic mediators, while favoring the release of mediators promoting tissue repair. Another important player is the mCSF receptor CSFR1, which is highly expressed in monocytes, macrophages and microglia. Here, we discuss the new interesting therapeutic avenue of the mCSF/CSFR1 axis on brain diseases. More specifically, mCSF cascade might stimulate the survival/proliferation of oligodendrocytes, enhance the immune response as well as modulate the release of growth factors and the phagocytic activity of immune cells to remove myelin debris and toxic proteins from the brain. |
| first_indexed | 2024-12-13T16:23:53Z |
| format | Article |
| id | doaj.art-a4b8ce190bba4b239d58b6aa2cdc5fef |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-13T16:23:53Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-a4b8ce190bba4b239d58b6aa2cdc5fef2022-12-21T23:38:40ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-12-011210.3389/fncel.2018.00499421519New Therapeutic Avenues of mCSF for Brain Diseases and InjuriesVincent PonsSerge RivestMacrophage colony-stimulating factor (mCSF) is a cytokine known to promote the recruitment of macrophages inducing the release of CCL2, a chemokine mobilizing monocytes to sites of inflammation. Additionally, it induces microglia/macrophage proliferation and the polarization of these cells towards a M2-like phenotype, impairing their ability to release pro-inflammatory factors and toxic mediators, while favoring the release of mediators promoting tissue repair. Another important player is the mCSF receptor CSFR1, which is highly expressed in monocytes, macrophages and microglia. Here, we discuss the new interesting therapeutic avenue of the mCSF/CSFR1 axis on brain diseases. More specifically, mCSF cascade might stimulate the survival/proliferation of oligodendrocytes, enhance the immune response as well as modulate the release of growth factors and the phagocytic activity of immune cells to remove myelin debris and toxic proteins from the brain.https://www.frontiersin.org/article/10.3389/fncel.2018.00499/fullmCSFmicrogliabrain diseasesinnate immune responsephagocytosis |
| spellingShingle | Vincent Pons Serge Rivest New Therapeutic Avenues of mCSF for Brain Diseases and Injuries Frontiers in Cellular Neuroscience mCSF microglia brain diseases innate immune response phagocytosis |
| title | New Therapeutic Avenues of mCSF for Brain Diseases and Injuries |
| title_full | New Therapeutic Avenues of mCSF for Brain Diseases and Injuries |
| title_fullStr | New Therapeutic Avenues of mCSF for Brain Diseases and Injuries |
| title_full_unstemmed | New Therapeutic Avenues of mCSF for Brain Diseases and Injuries |
| title_short | New Therapeutic Avenues of mCSF for Brain Diseases and Injuries |
| title_sort | new therapeutic avenues of mcsf for brain diseases and injuries |
| topic | mCSF microglia brain diseases innate immune response phagocytosis |
| url | https://www.frontiersin.org/article/10.3389/fncel.2018.00499/full |
| work_keys_str_mv | AT vincentpons newtherapeuticavenuesofmcsfforbraindiseasesandinjuries AT sergerivest newtherapeuticavenuesofmcsfforbraindiseasesandinjuries |