Changes induced in Biomphalaria glabrata (Say, 1818) following trials for artificial stimulation of its internal defense system
Biomphalaria glabrata can react through different pathways to Schistosoma mansoni miracidium penetration, according to the degree of resistance/susceptibility presented by different snail strains, which is a genetically determined character, resistance being the dominant feature. However, it has bee...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2006-10-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000900031 |
| _version_ | 1797756720151265280 |
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| author | Carine Machado Azevedo Claudia Cunha Borges Zilton A Andrade |
| author_facet | Carine Machado Azevedo Claudia Cunha Borges Zilton A Andrade |
| author_sort | Carine Machado Azevedo |
| collection | DOAJ |
| description | Biomphalaria glabrata can react through different pathways to Schistosoma mansoni miracidium penetration, according to the degree of resistance/susceptibility presented by different snail strains, which is a genetically determined character, resistance being the dominant feature. However, it has been observed that previous susceptible snail strain may change its reactive behavior along the course of infection, exhibiting later a pattern of cercarial shedding and histopatopathological picture compatible with high resistance. Such observation suggests the possibility of B. glabrata to develop a sort of adaptative immunity face a schistosome infection. To explore on this aspect, the present investigation looked for the behavior of S. mansoni infection in B. glabrata previously subjected to different means of artificial stimulation of its internal defense system. Snails previously inoculated with irradiated miracídia (Group I); treated with S. mansoni antigens (Group II) or with a non-related parasite antigen (Group III) were challenged with 20 viable S. mansoni miracidia, and later looked for cercarial shedding and histopathologic changes at different times from exposition. Nodules of hemocyte accumulations were found at the site of antigen injection. These nodules resembled solid granulomas, and were larger and more frequent in snails injected with S. mansoni products as compared to those injected with Capillaria hepatica. However, the presence of such granulomas did not avoid the S. mansoni challenge infection from developing in a similar way as that seen in controls. The data are indicative that hemocytes are able to proliferate locally when stimulated, such capacity also remaining localized, not being shared by the population of hemocytes located elsewhere within the snail body. |
| first_indexed | 2024-03-12T18:05:34Z |
| format | Article |
| id | doaj.art-a4b95fc3ef8a47b18a106d05ae515771 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:05:34Z |
| publishDate | 2006-10-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-a4b95fc3ef8a47b18a106d05ae5157712023-08-02T09:28:33ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602006-10-0110119920310.1590/S0074-02762006000900031Changes induced in Biomphalaria glabrata (Say, 1818) following trials for artificial stimulation of its internal defense systemCarine Machado AzevedoClaudia Cunha BorgesZilton A AndradeBiomphalaria glabrata can react through different pathways to Schistosoma mansoni miracidium penetration, according to the degree of resistance/susceptibility presented by different snail strains, which is a genetically determined character, resistance being the dominant feature. However, it has been observed that previous susceptible snail strain may change its reactive behavior along the course of infection, exhibiting later a pattern of cercarial shedding and histopatopathological picture compatible with high resistance. Such observation suggests the possibility of B. glabrata to develop a sort of adaptative immunity face a schistosome infection. To explore on this aspect, the present investigation looked for the behavior of S. mansoni infection in B. glabrata previously subjected to different means of artificial stimulation of its internal defense system. Snails previously inoculated with irradiated miracídia (Group I); treated with S. mansoni antigens (Group II) or with a non-related parasite antigen (Group III) were challenged with 20 viable S. mansoni miracidia, and later looked for cercarial shedding and histopathologic changes at different times from exposition. Nodules of hemocyte accumulations were found at the site of antigen injection. These nodules resembled solid granulomas, and were larger and more frequent in snails injected with S. mansoni products as compared to those injected with Capillaria hepatica. However, the presence of such granulomas did not avoid the S. mansoni challenge infection from developing in a similar way as that seen in controls. The data are indicative that hemocytes are able to proliferate locally when stimulated, such capacity also remaining localized, not being shared by the population of hemocytes located elsewhere within the snail body.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000900031hemocytesBiomphalaria glabrataSchistosoma mansoniantigens |
| spellingShingle | Carine Machado Azevedo Claudia Cunha Borges Zilton A Andrade Changes induced in Biomphalaria glabrata (Say, 1818) following trials for artificial stimulation of its internal defense system Memorias do Instituto Oswaldo Cruz hemocytes Biomphalaria glabrata Schistosoma mansoni antigens |
| title | Changes induced in Biomphalaria glabrata (Say, 1818) following trials for artificial stimulation of its internal defense system |
| title_full | Changes induced in Biomphalaria glabrata (Say, 1818) following trials for artificial stimulation of its internal defense system |
| title_fullStr | Changes induced in Biomphalaria glabrata (Say, 1818) following trials for artificial stimulation of its internal defense system |
| title_full_unstemmed | Changes induced in Biomphalaria glabrata (Say, 1818) following trials for artificial stimulation of its internal defense system |
| title_short | Changes induced in Biomphalaria glabrata (Say, 1818) following trials for artificial stimulation of its internal defense system |
| title_sort | changes induced in biomphalaria glabrata say 1818 following trials for artificial stimulation of its internal defense system |
| topic | hemocytes Biomphalaria glabrata Schistosoma mansoni antigens |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000900031 |
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