Regulation of Integrin Subunit Alpha 2 by miR-135b-5p Modulates Chemoresistance in Gastric Cancer

Regulation of Integrin Subunit Alpha 2 by miR-135b-5p Modulates Chemoresistance in Gastric Cancer

Chemotherapy has substantially improved gastric cancer (GC) patient outcomes in the past decades. However, the development of chemotherapy resistance has become the major cause of treatment failure. Although numerous molecules have been implicated in GC chemoresistance, its pathological mechanisms a...

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Bibliographic Details
Main Authors: Qi Wang, Tianyu Cao, Kai Guo, Yao Zhou, Hao Liu, Yanan Pan, Qiuqiu Hou, Yongzhan Nie, Daiming Fan, Yuanyuan Lu, Xiaodi Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
ITGA2
miR-135b-5p
gastric cancer
chemoresistance
MAPK pathway
EMT
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00308/full

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