Bacteriological and antibiotic profile of infection among infants in the post-neonatal period at a tertiary care hospital in South India
Purpose – Severe bacterial infection is a major cause of neonatal morbidity and mortality worldwide. Geographical-based demographic laboratory and clinical data are required to get a conclusion about the bacterial infection and their antibiotic susceptibility for the empiric antibiotic treatment in...
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| Format: | Article |
| Language: | English |
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College of Public Health Sciences, Chulalongkorn University
2022-02-01
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| Series: | Journal of Health Research |
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| Online Access: | https://www.emerald.com/insight/content/doi/10.1108/JHR-03-2020-0081/full/pdf?title=bacteriological-and-antibiotic-profile-of-infection-among-infants-in-the-post-neonatal-period-at-a-tertiary-care-hospital-in-south-india |
| _version_ | 1827837481503948800 |
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| author | Santhosh J. Thattil T.A. Ajith |
| author_facet | Santhosh J. Thattil T.A. Ajith |
| author_sort | Santhosh J. Thattil |
| collection | DOAJ |
| description | Purpose – Severe bacterial infection is a major cause of neonatal morbidity and mortality worldwide. Geographical-based demographic laboratory and clinical data are required to get a conclusion about the bacterial infection and their antibiotic susceptibility for the empiric antibiotic treatment in infants who presented with suspected infection. This study was aimed to find the most prevalent bacterial infection and antibiotic sensitivity among infants in the post-neonatal period presented at a tertiary care centre in South India. Design/methodology/approach – A cross-sectional study was designed among infants (29 days to 1 year old) presented with suspected infection in the paediatric department. Infants with positive culture report were analysed for the bacteriological and antibiotic profile from the medical records. Antibiotic sensitivity was determined for the isolated bacteria according to standard procedure and data statically analysed. Findings – Total of 218 samples (138 male and 80 female) were analysed. Most of the samples (171/218, 78.4%) were throat swab (p = 0.0247). Only one sample was cerebrospinal fluid from case of meningitis. Sample from upper RTI was major (162/218, 74.3%) with male dominance followed by stool samples from cases of diarrhoea (22/218, 10.0%). Staphylococcus aureus was the major organism identified in 46/171 (26.9 %) throat swabs. The most sensitive antibiotic against bacteria isolated from throat swab and CSF was gentamicin and cloxacillin. Netilmicin and piperacillin plus tazobactam were the sensitive antibiotics against bacteria isolated from stool, ear secretion and urine samples. Originality/value – Upper RTI was the prevalent bacterial infection followed by diarrhoea in infants in the post-neonatal period. Klebsiella pneumoniae was the common organism identified in the overall report followed by E. coli and S. aureus. Community-based awareness should be provided to follow good hygiene regularly in child care. Furthermore, avoid delay in seeking treatment and provide the medicine prescribed at the right time and in the right dose to limit the morbidity and bacterial resistance. |
| first_indexed | 2024-03-12T06:44:24Z |
| format | Article |
| id | doaj.art-a4bc17e26b704a758f2ec0555f10e671 |
| institution | Directory Open Access Journal |
| issn | 0857-4421 2586-940X |
| language | English |
| last_indexed | 2024-03-12T06:44:24Z |
| publishDate | 2022-02-01 |
| publisher | College of Public Health Sciences, Chulalongkorn University |
| record_format | Article |
| series | Journal of Health Research |
| spelling | doaj.art-a4bc17e26b704a758f2ec0555f10e6712023-09-03T00:43:39ZengCollege of Public Health Sciences, Chulalongkorn UniversityJournal of Health Research0857-44212586-940X2022-02-0136223124110.1108/JHR-03-2020-0081663212Bacteriological and antibiotic profile of infection among infants in the post-neonatal period at a tertiary care hospital in South IndiaSanthosh J. Thattil0T.A. Ajith1Department of Microbiology, Malabar Dental College, Thrissur, IndiaBiochemistry, Amala Institute of Medical Sciences, Thrissur, IndiaPurpose – Severe bacterial infection is a major cause of neonatal morbidity and mortality worldwide. Geographical-based demographic laboratory and clinical data are required to get a conclusion about the bacterial infection and their antibiotic susceptibility for the empiric antibiotic treatment in infants who presented with suspected infection. This study was aimed to find the most prevalent bacterial infection and antibiotic sensitivity among infants in the post-neonatal period presented at a tertiary care centre in South India. Design/methodology/approach – A cross-sectional study was designed among infants (29 days to 1 year old) presented with suspected infection in the paediatric department. Infants with positive culture report were analysed for the bacteriological and antibiotic profile from the medical records. Antibiotic sensitivity was determined for the isolated bacteria according to standard procedure and data statically analysed. Findings – Total of 218 samples (138 male and 80 female) were analysed. Most of the samples (171/218, 78.4%) were throat swab (p = 0.0247). Only one sample was cerebrospinal fluid from case of meningitis. Sample from upper RTI was major (162/218, 74.3%) with male dominance followed by stool samples from cases of diarrhoea (22/218, 10.0%). Staphylococcus aureus was the major organism identified in 46/171 (26.9 %) throat swabs. The most sensitive antibiotic against bacteria isolated from throat swab and CSF was gentamicin and cloxacillin. Netilmicin and piperacillin plus tazobactam were the sensitive antibiotics against bacteria isolated from stool, ear secretion and urine samples. Originality/value – Upper RTI was the prevalent bacterial infection followed by diarrhoea in infants in the post-neonatal period. Klebsiella pneumoniae was the common organism identified in the overall report followed by E. coli and S. aureus. Community-based awareness should be provided to follow good hygiene regularly in child care. Furthermore, avoid delay in seeking treatment and provide the medicine prescribed at the right time and in the right dose to limit the morbidity and bacterial resistance.https://www.emerald.com/insight/content/doi/10.1108/JHR-03-2020-0081/full/pdf?title=bacteriological-and-antibiotic-profile-of-infection-among-infants-in-the-post-neonatal-period-at-a-tertiary-care-hospital-in-south-indiaantibiotic susceptibilitybacteremianeonatesneonatal sepsisurinary tract infectionindia |
| spellingShingle | Santhosh J. Thattil T.A. Ajith Bacteriological and antibiotic profile of infection among infants in the post-neonatal period at a tertiary care hospital in South India Journal of Health Research antibiotic susceptibility bacteremia neonates neonatal sepsis urinary tract infection india |
| title | Bacteriological and antibiotic profile of infection among infants in the post-neonatal period at a tertiary care hospital in South India |
| title_full | Bacteriological and antibiotic profile of infection among infants in the post-neonatal period at a tertiary care hospital in South India |
| title_fullStr | Bacteriological and antibiotic profile of infection among infants in the post-neonatal period at a tertiary care hospital in South India |
| title_full_unstemmed | Bacteriological and antibiotic profile of infection among infants in the post-neonatal period at a tertiary care hospital in South India |
| title_short | Bacteriological and antibiotic profile of infection among infants in the post-neonatal period at a tertiary care hospital in South India |
| title_sort | bacteriological and antibiotic profile of infection among infants in the post neonatal period at a tertiary care hospital in south india |
| topic | antibiotic susceptibility bacteremia neonates neonatal sepsis urinary tract infection india |
| url | https://www.emerald.com/insight/content/doi/10.1108/JHR-03-2020-0081/full/pdf?title=bacteriological-and-antibiotic-profile-of-infection-among-infants-in-the-post-neonatal-period-at-a-tertiary-care-hospital-in-south-india |
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