Diet and medication in the treatment of hyperuricemia in hypertensive patients
OBJECTIVE: To evaluate the effects of diet and medication, either isolated or associated, on serum levels of uric acid in patients with hyperuricemia. METHODS: We studied patients from the Hypertension Unit of the University of Goias who had hyperuricemia (men > or = 8.5mg/dL and women > or =...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cardiologia (SBC)
2001-06-01
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| Series: | Arquivos Brasileiros de Cardiologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000600004 |
| _version_ | 1819050287818604544 |
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| author | Maria do Rosário Gondim Peixoto Estelamaris Tronco Monego Paulo César B. Veiga Jardim Magna Maria Carvalho Ana Luiza Lima Sousa Jonivan Siqueira de Oliveira Otavio Balestra Neto |
| author_facet | Maria do Rosário Gondim Peixoto Estelamaris Tronco Monego Paulo César B. Veiga Jardim Magna Maria Carvalho Ana Luiza Lima Sousa Jonivan Siqueira de Oliveira Otavio Balestra Neto |
| author_sort | Maria do Rosário Gondim Peixoto |
| collection | DOAJ |
| description | OBJECTIVE: To evaluate the effects of diet and medication, either isolated or associated, on serum levels of uric acid in patients with hyperuricemia. METHODS: We studied patients from the Hypertension Unit of the University of Goias who had hyperuricemia (men > or = 8.5mg/dL and women > or = 7.5mg/dL). We divided the patients into three groups: G1 (low purine diet), G2 (low purine diet + medication), and G3 (medication only). Patients received allopurinol, 150mg/day titrated up to 300mg/dL when necessary. Patients were evaluated with regards to their lifestyles (diet, smoking, physical, activity, alcohol consumption), uric acid, blood pressure, use of medication, body mass index, cholesterol, and triglyceride. Follow-up took place in weeks 0 (M1), 6 (M2), 12 (M3) during the intervention and in week 36(M4) after the study was completed. RESULTS: Fifty-five patients participated in the study, 31 women, mean age 54.4±10.6 years, body mass index 28.6±3.9kg/m². A similar reduction (p<0.001) in uric acid levels occurred in the three intervention groups. In week 36 (M4), after 24 weeks without intervention, a tendency toward elevation of uricemia was noted in G2 and G3, and a continuous drop in uricemia was noted in G1. No significant modifications were observed in the other variables analyzed. CONCLUSION: Considering the cost x benefit relationship, a diet low in purine should be the 1st therapeutic option for controlling hyperuricemia in patients with similar characteristic to the ones presented in this study. |
| first_indexed | 2024-12-21T11:45:39Z |
| format | Article |
| id | doaj.art-a4bdd98baafc4f878ad764259598d423 |
| institution | Directory Open Access Journal |
| issn | 0066-782X 1678-4170 |
| language | English |
| last_indexed | 2024-12-21T11:45:39Z |
| publishDate | 2001-06-01 |
| publisher | Sociedade Brasileira de Cardiologia (SBC) |
| record_format | Article |
| series | Arquivos Brasileiros de Cardiologia |
| spelling | doaj.art-a4bdd98baafc4f878ad764259598d4232022-12-21T19:05:11ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia0066-782X1678-41702001-06-0176646847210.1590/S0066-782X2001000600004Diet and medication in the treatment of hyperuricemia in hypertensive patientsMaria do Rosário Gondim PeixotoEstelamaris Tronco MonegoPaulo César B. Veiga JardimMagna Maria CarvalhoAna Luiza Lima SousaJonivan Siqueira de OliveiraOtavio Balestra NetoOBJECTIVE: To evaluate the effects of diet and medication, either isolated or associated, on serum levels of uric acid in patients with hyperuricemia. METHODS: We studied patients from the Hypertension Unit of the University of Goias who had hyperuricemia (men > or = 8.5mg/dL and women > or = 7.5mg/dL). We divided the patients into three groups: G1 (low purine diet), G2 (low purine diet + medication), and G3 (medication only). Patients received allopurinol, 150mg/day titrated up to 300mg/dL when necessary. Patients were evaluated with regards to their lifestyles (diet, smoking, physical, activity, alcohol consumption), uric acid, blood pressure, use of medication, body mass index, cholesterol, and triglyceride. Follow-up took place in weeks 0 (M1), 6 (M2), 12 (M3) during the intervention and in week 36(M4) after the study was completed. RESULTS: Fifty-five patients participated in the study, 31 women, mean age 54.4±10.6 years, body mass index 28.6±3.9kg/m². A similar reduction (p<0.001) in uric acid levels occurred in the three intervention groups. In week 36 (M4), after 24 weeks without intervention, a tendency toward elevation of uricemia was noted in G2 and G3, and a continuous drop in uricemia was noted in G1. No significant modifications were observed in the other variables analyzed. CONCLUSION: Considering the cost x benefit relationship, a diet low in purine should be the 1st therapeutic option for controlling hyperuricemia in patients with similar characteristic to the ones presented in this study.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000600004arterial hypertensionuric acidlow-purine diet |
| spellingShingle | Maria do Rosário Gondim Peixoto Estelamaris Tronco Monego Paulo César B. Veiga Jardim Magna Maria Carvalho Ana Luiza Lima Sousa Jonivan Siqueira de Oliveira Otavio Balestra Neto Diet and medication in the treatment of hyperuricemia in hypertensive patients Arquivos Brasileiros de Cardiologia arterial hypertension uric acid low-purine diet |
| title | Diet and medication in the treatment of hyperuricemia in hypertensive patients |
| title_full | Diet and medication in the treatment of hyperuricemia in hypertensive patients |
| title_fullStr | Diet and medication in the treatment of hyperuricemia in hypertensive patients |
| title_full_unstemmed | Diet and medication in the treatment of hyperuricemia in hypertensive patients |
| title_short | Diet and medication in the treatment of hyperuricemia in hypertensive patients |
| title_sort | diet and medication in the treatment of hyperuricemia in hypertensive patients |
| topic | arterial hypertension uric acid low-purine diet |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000600004 |
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