Maternal parity and the risk of congenital heart defects in offspring: a dose-response meta-analysis of epidemiological observational studies.
BACKGROUND: Epidemiological studies have reported conflicting results regarding maternal parity and the risk of congenital heart defects (CHDs). However, a meta-analysis of the association between maternal parity and CHDs in offspring has not been conducted. METHODS: We searched MEDLINE and EMBASE f...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4189919?pdf=render |
| _version_ | 1818231623456391168 |
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| author | Yu Feng Di Yu Tao Chen Jin Liu Xing Tong Lei Yang Min Da Shutong Shen Changfeng Fan Song Wang Xuming Mo |
| author_facet | Yu Feng Di Yu Tao Chen Jin Liu Xing Tong Lei Yang Min Da Shutong Shen Changfeng Fan Song Wang Xuming Mo |
| author_sort | Yu Feng |
| collection | DOAJ |
| description | BACKGROUND: Epidemiological studies have reported conflicting results regarding maternal parity and the risk of congenital heart defects (CHDs). However, a meta-analysis of the association between maternal parity and CHDs in offspring has not been conducted. METHODS: We searched MEDLINE and EMBASE for articles catalogued between their inception and March 8, 2014; we identified relevant published studies that assessed the association between maternal parity and CHD risk. Two authors independently assessed the eligibility of the retrieved articles and extracted data from them. Study-specific relative risk estimates were pooled by random-effects or fixed-effects models. From the 11272 references, a total of 16 case-control studies and 3 cohort studies were enrolled in this meta-analysis. RESULTS: The overall relative risk of CHD in parous versus nulliparous women was 1.01 (95% CI, 0.97-1.06; Q = 32.34; P = 0.006; I2 = 53.6%). Furthermore, we observed a significant association between the highest versus lowest parity number, with an overall RR = 1.20 (95% CI, 1.10-1.31; (Q = 74.61, P<0.001, I2 = 82.6%). A dose-response analysis also indicated a positive effect of maternal parity on CHD risk, and the overall increase in relative risk per one live birth was 1.06 (95% CI, 1.02-1.09); Q = 68.09; P<0.001; I2 = 80.9%). We conducted stratified and meta-regression analyses to identify the origin of the heterogeneity among studies. A Galbraith plot was created to graphically assess the sources of heterogeneity. CONCLUSION: In summary, this meta-analysis provided a robust estimate of the positive association between maternal parity and risk of CHD. |
| first_indexed | 2024-12-12T10:53:20Z |
| format | Article |
| id | doaj.art-a4c02a6ebbef45d7a608864abb50402b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T10:53:20Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a4c02a6ebbef45d7a608864abb50402b2022-12-22T00:26:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e10894410.1371/journal.pone.0108944Maternal parity and the risk of congenital heart defects in offspring: a dose-response meta-analysis of epidemiological observational studies.Yu FengDi YuTao ChenJin LiuXing TongLei YangMin DaShutong ShenChangfeng FanSong WangXuming MoBACKGROUND: Epidemiological studies have reported conflicting results regarding maternal parity and the risk of congenital heart defects (CHDs). However, a meta-analysis of the association between maternal parity and CHDs in offspring has not been conducted. METHODS: We searched MEDLINE and EMBASE for articles catalogued between their inception and March 8, 2014; we identified relevant published studies that assessed the association between maternal parity and CHD risk. Two authors independently assessed the eligibility of the retrieved articles and extracted data from them. Study-specific relative risk estimates were pooled by random-effects or fixed-effects models. From the 11272 references, a total of 16 case-control studies and 3 cohort studies were enrolled in this meta-analysis. RESULTS: The overall relative risk of CHD in parous versus nulliparous women was 1.01 (95% CI, 0.97-1.06; Q = 32.34; P = 0.006; I2 = 53.6%). Furthermore, we observed a significant association between the highest versus lowest parity number, with an overall RR = 1.20 (95% CI, 1.10-1.31; (Q = 74.61, P<0.001, I2 = 82.6%). A dose-response analysis also indicated a positive effect of maternal parity on CHD risk, and the overall increase in relative risk per one live birth was 1.06 (95% CI, 1.02-1.09); Q = 68.09; P<0.001; I2 = 80.9%). We conducted stratified and meta-regression analyses to identify the origin of the heterogeneity among studies. A Galbraith plot was created to graphically assess the sources of heterogeneity. CONCLUSION: In summary, this meta-analysis provided a robust estimate of the positive association between maternal parity and risk of CHD.http://europepmc.org/articles/PMC4189919?pdf=render |
| spellingShingle | Yu Feng Di Yu Tao Chen Jin Liu Xing Tong Lei Yang Min Da Shutong Shen Changfeng Fan Song Wang Xuming Mo Maternal parity and the risk of congenital heart defects in offspring: a dose-response meta-analysis of epidemiological observational studies. PLoS ONE |
| title | Maternal parity and the risk of congenital heart defects in offspring: a dose-response meta-analysis of epidemiological observational studies. |
| title_full | Maternal parity and the risk of congenital heart defects in offspring: a dose-response meta-analysis of epidemiological observational studies. |
| title_fullStr | Maternal parity and the risk of congenital heart defects in offspring: a dose-response meta-analysis of epidemiological observational studies. |
| title_full_unstemmed | Maternal parity and the risk of congenital heart defects in offspring: a dose-response meta-analysis of epidemiological observational studies. |
| title_short | Maternal parity and the risk of congenital heart defects in offspring: a dose-response meta-analysis of epidemiological observational studies. |
| title_sort | maternal parity and the risk of congenital heart defects in offspring a dose response meta analysis of epidemiological observational studies |
| url | http://europepmc.org/articles/PMC4189919?pdf=render |
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