Patterns of Cough Medication Prescribing among Patients with Chronic Cough in Florida: 2012–2021
Among patients with chronic cough (CC) in the 2012–2021 statewide OneFlorida Clinical Research Consortium database, we examined trends in cough medication (CM) prescribing prevalence over time in repeated cross-sectional analyses and identified distinct CM utilization trajectories using group-based...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/19/6286 |
| _version_ | 1797575699881525248 |
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| author | Seonkyeong Yang Shu Huang Juan M. Hincapie-Castillo Xuehua Ke Helen Ding Jonathan Schelfhout Mandel R. Sher Bobby Jones Debbie L. Wilson Wei-Hsuan Lo-Ciganic |
| author_facet | Seonkyeong Yang Shu Huang Juan M. Hincapie-Castillo Xuehua Ke Helen Ding Jonathan Schelfhout Mandel R. Sher Bobby Jones Debbie L. Wilson Wei-Hsuan Lo-Ciganic |
| author_sort | Seonkyeong Yang |
| collection | DOAJ |
| description | Among patients with chronic cough (CC) in the 2012–2021 statewide OneFlorida Clinical Research Consortium database, we examined trends in cough medication (CM) prescribing prevalence over time in repeated cross-sectional analyses and identified distinct CM utilization trajectories using group-based trajectory modeling (GBTM) in a retrospective cohort study. Among eligible adults (≥18 years) without cancer/benign respiratory tumor diagnoses, we identified CC patients and non-CC patients with any cough-related diagnosis. In the GBTM analysis, we calculated the number of monthly prescriptions for any CMs (excluding gabapentinoids) during the 12 months from the first qualifying cough event to identify distinct utilization trajectories. From 2012 to 2021, benzonatate (9.6% to 26.1%), dextromethorphan (5.2% to 8.6%), and gabapentinoid (5.3% to 14.4%) use increased among CC patients, while opioid antitussive use increased from 2012 to 2015 and decreased thereafter (8.4% in 2012, 14.7% in 2015, 6.7% in 2021; all <i>p</i> < 0.001). Of 15,566 CC patients and 655,250 non-CC patients identified in the GBTM analysis, CC patients had substantial burdens of respiratory/non-respiratory comorbidities and healthcare service and concomitant medication use compared to non-CC patients. Among CC patients, GBTM identified three distinct CM utilization trajectories: (1) no CM use (n = 11,222; 72.1%); (2) declining CM use (n = 4105; 26.4%); and (3) chronic CM use (n = 239; 1.5%). CC patients in Florida had limited CM use with increasing trends in use of benzonatate, dextromethorphan, and gabapentinoids and a decreasing trend in opioid antitussive use. CC patients, particularly with chronic prescription CM use, experienced substantial disease burden. |
| first_indexed | 2024-03-10T21:41:58Z |
| format | Article |
| id | doaj.art-a4c21b6a88274df88312ef8d0471327c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T21:41:58Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a4c21b6a88274df88312ef8d0471327c2023-11-19T14:36:43ZengMDPI AGJournal of Clinical Medicine2077-03832023-09-011219628610.3390/jcm12196286Patterns of Cough Medication Prescribing among Patients with Chronic Cough in Florida: 2012–2021Seonkyeong Yang0Shu Huang1Juan M. Hincapie-Castillo2Xuehua Ke3Helen Ding4Jonathan Schelfhout5Mandel R. Sher6Bobby Jones7Debbie L. Wilson8Wei-Hsuan Lo-Ciganic9Department of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, FL 32611, USADepartment of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, FL 32611, USADepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USACenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Rahway, NJ 07065, USACenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Rahway, NJ 07065, USACenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Rahway, NJ 07065, USACenter for Cough, Largo, FL 33778, USADepartment of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, FL 32611, USADepartment of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, FL 32611, USADepartment of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, FL 32611, USAAmong patients with chronic cough (CC) in the 2012–2021 statewide OneFlorida Clinical Research Consortium database, we examined trends in cough medication (CM) prescribing prevalence over time in repeated cross-sectional analyses and identified distinct CM utilization trajectories using group-based trajectory modeling (GBTM) in a retrospective cohort study. Among eligible adults (≥18 years) without cancer/benign respiratory tumor diagnoses, we identified CC patients and non-CC patients with any cough-related diagnosis. In the GBTM analysis, we calculated the number of monthly prescriptions for any CMs (excluding gabapentinoids) during the 12 months from the first qualifying cough event to identify distinct utilization trajectories. From 2012 to 2021, benzonatate (9.6% to 26.1%), dextromethorphan (5.2% to 8.6%), and gabapentinoid (5.3% to 14.4%) use increased among CC patients, while opioid antitussive use increased from 2012 to 2015 and decreased thereafter (8.4% in 2012, 14.7% in 2015, 6.7% in 2021; all <i>p</i> < 0.001). Of 15,566 CC patients and 655,250 non-CC patients identified in the GBTM analysis, CC patients had substantial burdens of respiratory/non-respiratory comorbidities and healthcare service and concomitant medication use compared to non-CC patients. Among CC patients, GBTM identified three distinct CM utilization trajectories: (1) no CM use (n = 11,222; 72.1%); (2) declining CM use (n = 4105; 26.4%); and (3) chronic CM use (n = 239; 1.5%). CC patients in Florida had limited CM use with increasing trends in use of benzonatate, dextromethorphan, and gabapentinoids and a decreasing trend in opioid antitussive use. CC patients, particularly with chronic prescription CM use, experienced substantial disease burden.https://www.mdpi.com/2077-0383/12/19/6286coughchronic coughcough hypersensitivity syndromeantitussiveopioid antitussivebenzonatate |
| spellingShingle | Seonkyeong Yang Shu Huang Juan M. Hincapie-Castillo Xuehua Ke Helen Ding Jonathan Schelfhout Mandel R. Sher Bobby Jones Debbie L. Wilson Wei-Hsuan Lo-Ciganic Patterns of Cough Medication Prescribing among Patients with Chronic Cough in Florida: 2012–2021 Journal of Clinical Medicine cough chronic cough cough hypersensitivity syndrome antitussive opioid antitussive benzonatate |
| title | Patterns of Cough Medication Prescribing among Patients with Chronic Cough in Florida: 2012–2021 |
| title_full | Patterns of Cough Medication Prescribing among Patients with Chronic Cough in Florida: 2012–2021 |
| title_fullStr | Patterns of Cough Medication Prescribing among Patients with Chronic Cough in Florida: 2012–2021 |
| title_full_unstemmed | Patterns of Cough Medication Prescribing among Patients with Chronic Cough in Florida: 2012–2021 |
| title_short | Patterns of Cough Medication Prescribing among Patients with Chronic Cough in Florida: 2012–2021 |
| title_sort | patterns of cough medication prescribing among patients with chronic cough in florida 2012 2021 |
| topic | cough chronic cough cough hypersensitivity syndrome antitussive opioid antitussive benzonatate |
| url | https://www.mdpi.com/2077-0383/12/19/6286 |
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