Cymerus™ iPSC-MSCs significantly prolong survival in a pre-clinical, humanized mouse model of Graft-vs-host disease

Cymerus™ iPSC-MSCs significantly prolong survival in a pre-clinical, humanized mouse model of Graft-vs-host disease

The immune-mediated tissue destruction of graft-vs-host disease (GvHD) remains a major barrier to greater use of hematopoietic stem cell transplantation (HSCT). Mesenchymal stem cells (MSCs) have intrinsic immunosuppressive qualities and are being actively investigated as a therapeutic strategy for...

Full description

Bibliographic Details
Main Authors:	E. Ilker Ozay, Jyothi Vijayaraghavan, Gabriela Gonzalez-Perez, Sudarvili Shanthalingam, Heather L. Sherman, Daniel T. Garrigan, Jr., Karthik Chandiran, Joe A. Torres, Barbara A. Osborne, Gregory N. Tew, Igor I. Slukvin, Ross A. Macdonald, Kilian Kelly, Lisa M. Minter
Format:	Article
Language:	English
Published:	Elsevier 2019-03-01
Series:	Stem Cell Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506119300315

Similar Items

PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment
by: Nidhi Jadon, et al.
Published: (2024-01-01)

iPSC-Derived MSCs Are a Distinct Entity of MSCs with Higher Therapeutic Potential than Their Donor-Matched Parental MSCs
by: Hae-Ri Lee, et al.
Published: (2023-01-01)

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
by: Lucas-Sebastian Spitzhorn, et al.
Published: (2019-03-01)

Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation
by: Yin Yao, et al.
Published: (2018-11-01)

Low-Intensity Pulsed Ultrasound Promotes Osteogenic Potential of iPSC-Derived MSCs but Fails to Simplify the iPSC-EB-MSC Differentiation Process
by: Ziyi Hua, et al.
Published: (2022-05-01)

Therapeutic effect of TSG-6 engineered iPSC-derived MSCs on experimental periodontitis in rats: a pilot study.
by: Heng Yang, et al.
Published: (2014-01-01)

iPSC-derived mesenchymal stromal cells are less supportive than primary MSCs for co-culture of hematopoietic progenitor cells
by: Theresa Vasko, et al.
Published: (2016-04-01)

MSCs vs. iPSCs: Potential in therapeutic applications
by: Kalaiselvaan Thanaskody, et al.
Published: (2022-11-01)

Characterizing the secretome of licensed hiPSC-derived MSCs
by: Yolande F. M. Ramos, et al.
Published: (2022-09-01)

The CIRM iPSC repository
by: Stephen S. Lin, et al.
Published: (2020-04-01)

CiRA iPSC seed stocks (CiRA's iPSC Stock Project)
by: Tadaaki Hanatani, et al.
Published: (2021-01-01)

iPSC for modeling neurodegenerative disorders
by: Valeria Valadez-Barba, et al.
Published: (2020-12-01)

Exosomal miR-9-5p derived from iPSC-MSCs ameliorates doxorubicin-induced cardiomyopathy by inhibiting cardiomyocyte senescence
by: Huifeng Zheng, et al.
Published: (2024-04-01)

EV products obtained from iPSC-derived MSCs show batch-to-batch variations in their ability to modulate allogeneic immune responses in vitro
by: Tobias Tertel, et al.
Published: (2023-10-01)

MFN2 knockdown promotes osteogenic differentiation of iPSC-MSCs through aerobic glycolysis mediated by the Wnt/β-catenin signaling pathway
by: Lidi Deng, et al.
Published: (2022-04-01)

iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy
by: Yuelin Zhang, et al.
Published: (2016-10-01)

Maturing iPSC-Derived Cardiomyocytes
by: Bor Luen Tang
Published: (2020-01-01)

Systemic Supplementation of Collagen VI by Neonatal Transplantation of iPSC-Derived MSCs Improves Histological Phenotype and Function of Col6-Deficient Model Mice
by: Aya Harada, et al.
Published: (2021-11-01)

The Global Alliance for iPSC Therapies (GAiT)
by: Stephen Sullivan, et al.
Published: (2020-12-01)

Pro-maturational effects of human iPSC-derived cortical astrocytes upon iPSC-derived cortical neurons
by: Anne Hedegaard, et al.
Published: (2020)

Generation of iPSC line iPSC-FH2.1 in hypoxic conditions from human foreskin fibroblasts
by: María Questa, et al.
Published: (2016-03-01)

The Utilisation of Hydrogels for iPSC-Cardiomyocyte Research
by: Leena Patel, et al.
Published: (2023-06-01)

The utilisation of hydrogels for iPSC-cardiomyocyte research
by: Patel, L, et al.
Published: (2023)

Human iPSC banking: barriers and opportunities
by: Ching-Ying Huang, et al.
Published: (2019-10-01)

Systematic assessment of variability in the proteome of iPSC derivatives
by: Stephanie D. Beekhuis-Hoekstra, et al.
Published: (2021-10-01)

414 Efficacy and immunogenicity of induced pluripotent stem cell (iPSC) vaccine is independent of iPSC viability in a prophylactic mouse model of breast cancer
by: Hui Huang, et al.
Published: (2023-11-01)

iPSC-derived cells for whole liver bioengineering
by: Kayque Alves Telles-Silva, et al.
Published: (2024-02-01)

Engineering considerations of iPSC-based personalized medicine
by: Sangbae Park, et al.
Published: (2023-07-01)

Modeling of Frontotemporal Dementia Using iPSC Technology
by: Minchul Kim, et al.
Published: (2020-07-01)

The iPSC Awakens ANGPTL3 in Tangier Disease
by: Man K.S. Lee, et al.
Published: (2017-04-01)

The EBiSC iPSC bank for disease studies
by: Rachel Steeg, et al.
Published: (2020-12-01)

Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D
by: John J. Jamieson, et al.
Published: (2019-06-01)

Patient-specific iPSC-derived cellular models of LGMDR1
by: A.J. Mateos-Aierdi, et al.
Published: (2021-05-01)

Suspension culture improves iPSC expansion and pluripotency phenotype
by: Nerea Cuesta-Gomez, et al.
Published: (2023-06-01)

Small Extracellular Vesicles Secreted by iPSC-Derived MSCs Ameliorate Pulmonary Inflammation and Lung Injury Induced by Sepsis through Delivery of miR-125b-5p
by: Wei Peng, et al.
Published: (2023-01-01)

Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line
by: Satoshi Matsui, et al.
Published: (2019-03-01)

Automated high-content imaging in iPSC-derived neuronal progenitors
by: Apostolos Papandreou, et al.
Published: (2023-03-01)

Leukotoxin of Bibersteinia trehalosi Contains a Unique Neutralizing Epitope, and a Non-Neutralizing Epitope Shared with Mannheimia haemolytica Leukotoxin
by: Arumugam Murugananthan, et al.
Published: (2018-05-01)

iPSC-cardiomyocytes in the preclinical prediction of candidate pharmaceutical toxicity
by: Tim Y. T. Lee, et al.
Published: (2024-02-01)

Stochastic biological system-of-systems modelling for iPSC culture
by: Hua Zheng, et al.
Published: (2024-01-01)