Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization
Spreading depolarization (SD), a self-propagated wave of transient depolarization, regularly occurs in the cortex after acute brain insults and is now referred as an important diagnostic and therapeutic target in patients with acute brain injury. Here, we show that the amygdala, the limbic structure...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/9/2183 |
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| author | Mariia P. Smirnova Tatiana M. Medvedeva Irina V. Pavlova Lyudmila V. Vinogradova |
| author_facet | Mariia P. Smirnova Tatiana M. Medvedeva Irina V. Pavlova Lyudmila V. Vinogradova |
| author_sort | Mariia P. Smirnova |
| collection | DOAJ |
| description | Spreading depolarization (SD), a self-propagated wave of transient depolarization, regularly occurs in the cortex after acute brain insults and is now referred as an important diagnostic and therapeutic target in patients with acute brain injury. Here, we show that the amygdala, the limbic structure responsible for post-injury neuropsychological symptoms, exhibits strong regional heterogeneity in vulnerability to SD with high susceptibility of its basolateral (BLA) region and resilience of its centromedial (CMA) region to triggering SD by acute focal damage. The BLA micro-injury elicited SD twice as often compared with identical injury of the CMA region (71% vs. 33%). Spatiotemporal features of SDs triggered in the amygdala indicated diverse patterns of the SD propagation to the cortex. Our results suggest that even relatively small cerebral structures can exhibit regional gradients in their susceptibility to SD and the heterogeneity may contribute to the generation of complex SD patterns in the injured brain. |
| first_indexed | 2024-03-10T00:39:31Z |
| format | Article |
| id | doaj.art-a4c274efe5544a32a167e0fe43ed88c6 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:39:31Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a4c274efe5544a32a167e0fe43ed88c62023-11-23T15:10:30ZengMDPI AGBiomedicines2227-90592022-09-01109218310.3390/biomedicines10092183Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading DepolarizationMariia P. Smirnova0Tatiana M. Medvedeva1Irina V. Pavlova2Lyudmila V. Vinogradova3Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, RussiaInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, RussiaInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, RussiaInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, RussiaSpreading depolarization (SD), a self-propagated wave of transient depolarization, regularly occurs in the cortex after acute brain insults and is now referred as an important diagnostic and therapeutic target in patients with acute brain injury. Here, we show that the amygdala, the limbic structure responsible for post-injury neuropsychological symptoms, exhibits strong regional heterogeneity in vulnerability to SD with high susceptibility of its basolateral (BLA) region and resilience of its centromedial (CMA) region to triggering SD by acute focal damage. The BLA micro-injury elicited SD twice as often compared with identical injury of the CMA region (71% vs. 33%). Spatiotemporal features of SDs triggered in the amygdala indicated diverse patterns of the SD propagation to the cortex. Our results suggest that even relatively small cerebral structures can exhibit regional gradients in their susceptibility to SD and the heterogeneity may contribute to the generation of complex SD patterns in the injured brain.https://www.mdpi.com/2227-9059/10/9/2183spreading depolarizationintracerebral micro-injurybasolateral amygdalacentromedial amygdala |
| spellingShingle | Mariia P. Smirnova Tatiana M. Medvedeva Irina V. Pavlova Lyudmila V. Vinogradova Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization Biomedicines spreading depolarization intracerebral micro-injury basolateral amygdala centromedial amygdala |
| title | Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization |
| title_full | Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization |
| title_fullStr | Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization |
| title_full_unstemmed | Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization |
| title_short | Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization |
| title_sort | region specific vulnerability of the amygdala to injury induced spreading depolarization |
| topic | spreading depolarization intracerebral micro-injury basolateral amygdala centromedial amygdala |
| url | https://www.mdpi.com/2227-9059/10/9/2183 |
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