The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study
Embryo morphology and morphokinetics have been studied for their association with euploid embryos. However, the results are controversial, especially in the advanced-aged women group, when the risk of aneuploidy increases significantly. This prospective cohort study evaluated the association between...
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/2/626 |
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| author | Pornchanit Santamonkunrot Sonsiri Samutchinda Pornsri Niransuk Chonthicha Satirapod Matchuporn Sukprasert |
| author_facet | Pornchanit Santamonkunrot Sonsiri Samutchinda Pornsri Niransuk Chonthicha Satirapod Matchuporn Sukprasert |
| author_sort | Pornchanit Santamonkunrot |
| collection | DOAJ |
| description | Embryo morphology and morphokinetics have been studied for their association with euploid embryos. However, the results are controversial, especially in the advanced-aged women group, when the risk of aneuploidy increases significantly. This prospective cohort study evaluated the association between embryo development between day-3 cleavage and day-5 blastocyst stages and euploidy rates, determined using preimplantation genetic testing for aneuploidy (PGT-A). Embryos from women aged 35 years and above who underwent intracytoplasmic sperm injections and PGT-A were studied. Day-3 cleavage-stage embryos were evaluated for their cell number, and day-5 blastocyst-stage embryos were evaluated for their morphological grade. Embryo development from day 3 to day 5 was categorized as either good or poor development and evaluated for its association with the PGT-A results. We evaluated 325 embryos from 101 infertile couples. It was found that 55.17% of blastocysts with good development and 29.83% with poor development were euploid. A significant association was found between embryo development and euploidy rates in advanced-aged women (<i>p</i> < 0.001). Also, there were significantly higher rates of euploid embryos with good blastocyst morphological grades, especially blastocyst expansion grades and trophectoderm grades. In conclusion, embryo morphokinetics shows promising results in predicting euploidy in advanced female age. |
| first_indexed | 2024-03-08T09:51:07Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T09:51:07Z |
| publishDate | 2024-01-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-a4c32a984a18408f8538fbd03770d58c2024-01-29T14:03:52ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113262610.3390/jcm13020626The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort StudyPornchanit Santamonkunrot0Sonsiri Samutchinda1Pornsri Niransuk2Chonthicha Satirapod3Matchuporn Sukprasert4Reproductive Endocrinology and Infertility Unit, Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandReproductive Endocrinology and Infertility Unit, Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandReproductive Endocrinology and Infertility Unit, Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandReproductive Endocrinology and Infertility Unit, Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandReproductive Endocrinology and Infertility Unit, Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandEmbryo morphology and morphokinetics have been studied for their association with euploid embryos. However, the results are controversial, especially in the advanced-aged women group, when the risk of aneuploidy increases significantly. This prospective cohort study evaluated the association between embryo development between day-3 cleavage and day-5 blastocyst stages and euploidy rates, determined using preimplantation genetic testing for aneuploidy (PGT-A). Embryos from women aged 35 years and above who underwent intracytoplasmic sperm injections and PGT-A were studied. Day-3 cleavage-stage embryos were evaluated for their cell number, and day-5 blastocyst-stage embryos were evaluated for their morphological grade. Embryo development from day 3 to day 5 was categorized as either good or poor development and evaluated for its association with the PGT-A results. We evaluated 325 embryos from 101 infertile couples. It was found that 55.17% of blastocysts with good development and 29.83% with poor development were euploid. A significant association was found between embryo development and euploidy rates in advanced-aged women (<i>p</i> < 0.001). Also, there were significantly higher rates of euploid embryos with good blastocyst morphological grades, especially blastocyst expansion grades and trophectoderm grades. In conclusion, embryo morphokinetics shows promising results in predicting euploidy in advanced female age.https://www.mdpi.com/2077-0383/13/2/626preimplantation genetic testinganeuploidyadvanced-aged womenmorphologymorphogeneticembryo development |
| spellingShingle | Pornchanit Santamonkunrot Sonsiri Samutchinda Pornsri Niransuk Chonthicha Satirapod Matchuporn Sukprasert The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study Journal of Clinical Medicine preimplantation genetic testing aneuploidy advanced-aged women morphology morphogenetic embryo development |
| title | The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study |
| title_full | The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study |
| title_fullStr | The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study |
| title_full_unstemmed | The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study |
| title_short | The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study |
| title_sort | association between embryo development and chromosomal results from pgt a in women of advanced age a prospective cohort study |
| topic | preimplantation genetic testing aneuploidy advanced-aged women morphology morphogenetic embryo development |
| url | https://www.mdpi.com/2077-0383/13/2/626 |
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