Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA)
Atherosclerosis (AS) is one of the most common cardiovascular system diseases which seriously affects public health in modern society. Finding potential biomarkers in the complicated pathological progression of AS is of great significance for the prevention and treatment of AS. Studies have shown th...
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PeerJ Inc.
2020-11-01
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| Online Access: | https://peerj.com/articles/10001.pdf |
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| author | Shanshan Lu Qin Liang Yanqing Huang Fanming Meng Junwen Liu |
| author_facet | Shanshan Lu Qin Liang Yanqing Huang Fanming Meng Junwen Liu |
| author_sort | Shanshan Lu |
| collection | DOAJ |
| description | Atherosclerosis (AS) is one of the most common cardiovascular system diseases which seriously affects public health in modern society. Finding potential biomarkers in the complicated pathological progression of AS is of great significance for the prevention and treatment of AS. Studies have shown that long noncoding RNAs (lncRNAs) can be widely involved in the regulation of many physiological processes, and have important roles in different stages of AS formation. LncRNAs can be secreted into the circulatory system through exosomes, microvesicles, and apoptotic bodies. Recently, increasing studies have been focused on the relationships between circulating lncRNAs and AS development. The lncRNAs in circulating blood are expected to be new non-invasive diagnostic markers for monitoring the progression of AS. We briefly reviewed the previously reported lncRNA transcripts which related to AS development and detectable in circulating blood, including ANRIL, SENCR, CoroMarker, LIPCAR, HIF1α-AS1, LncRNA H19, APPAT, KCNQ1OT1, LncPPARδ, LincRNA-p21, MALAT1, MIAT, and UCA1. Further researches and a definition of atherosclerosis-associated circulating lncRNA (ASCLncRNA) were also discussed. |
| first_indexed | 2024-03-09T06:45:33Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:45:33Z |
| publishDate | 2020-11-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-a4c3df99c4fe47e8bde40b8e9067e0b42023-12-03T10:36:15ZengPeerJ Inc.PeerJ2167-83592020-11-018e1000110.7717/peerj.10001Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA)Shanshan Lu0Qin Liang1Yanqing Huang2Fanming Meng3Junwen Liu4Department of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, Hunan Province, ChinaDepartment of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, Hunan Province, ChinaDepartment of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, Hunan Province, ChinaDepartment of Parasitology, School of Basic Medical Science, Central South University, Changsha, Hunan Province, ChinaDepartment of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, Hunan Province, ChinaAtherosclerosis (AS) is one of the most common cardiovascular system diseases which seriously affects public health in modern society. Finding potential biomarkers in the complicated pathological progression of AS is of great significance for the prevention and treatment of AS. Studies have shown that long noncoding RNAs (lncRNAs) can be widely involved in the regulation of many physiological processes, and have important roles in different stages of AS formation. LncRNAs can be secreted into the circulatory system through exosomes, microvesicles, and apoptotic bodies. Recently, increasing studies have been focused on the relationships between circulating lncRNAs and AS development. The lncRNAs in circulating blood are expected to be new non-invasive diagnostic markers for monitoring the progression of AS. We briefly reviewed the previously reported lncRNA transcripts which related to AS development and detectable in circulating blood, including ANRIL, SENCR, CoroMarker, LIPCAR, HIF1α-AS1, LncRNA H19, APPAT, KCNQ1OT1, LncPPARδ, LincRNA-p21, MALAT1, MIAT, and UCA1. Further researches and a definition of atherosclerosis-associated circulating lncRNA (ASCLncRNA) were also discussed.https://peerj.com/articles/10001.pdfAtherosclerosisBiomarkerCirculating lncRNAsNon-invasive diagnosis |
| spellingShingle | Shanshan Lu Qin Liang Yanqing Huang Fanming Meng Junwen Liu Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA) PeerJ Atherosclerosis Biomarker Circulating lncRNAs Non-invasive diagnosis |
| title | Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA) |
| title_full | Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA) |
| title_fullStr | Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA) |
| title_full_unstemmed | Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA) |
| title_short | Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA) |
| title_sort | definition and review on a category of long non coding rna atherosclerosis associated circulating lncrna asclncrna |
| topic | Atherosclerosis Biomarker Circulating lncRNAs Non-invasive diagnosis |
| url | https://peerj.com/articles/10001.pdf |
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