<i>Drosophila</i> INDY and Mammalian INDY: Major Differences in Transport Mechanism and Structural Features despite Mostly Similar Biological Functions

<i>Drosophila</i> INDY and Mammalian INDY: Major Differences in Transport Mechanism and Structural Features despite Mostly Similar Biological Functions

INDY (I’m Not Dead Yet) is a plasma membrane transporter for citrate, first identified in <i>Drosophila</i>. Partial deficiency of INDY extends lifespan in this organism in a manner similar to that of caloric restriction. The mammalian counterpart (NaCT/SLC13A5) also transports citrate....

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Bibliographic Details
Main Authors: Valeria Jaramillo-Martinez, Sathish Sivaprakasam, Vadivel Ganapathy, Ina L. Urbatsch
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Metabolites
Subjects:
I’m Not Dead Yet
caloric restriction
lifespan
<i>Drosophila</i> INDY
mammalian INDY
SLC13A5
Online Access:https://www.mdpi.com/2218-1989/11/10/669

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