Apoptosis, Pyroptosis, and Ferroptosis Conspiringly Induce Immunosuppressive Hepatocellular Carcinoma Microenvironment and γδ T-Cell Imbalance

Apoptosis, Pyroptosis, and Ferroptosis Conspiringly Induce Immunosuppressive Hepatocellular Carcinoma Microenvironment and γδ T-Cell Imbalance

Hepatocellular carcinoma (HCC) is highly malignant and prone to metastasize due to the heterogeneous and immunosuppressive tumor microenvironment (TME). Programmed cell deaths (PCDs) including apoptosis, ferroptosis, and pyroptosis routinely occur in the HCC TME and participate in tumorigenesis. How...

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Bibliographic Details
Main Authors: Yi Hu, Dan Chen, Minjing Hong, Jing Liu, Yijia Li, Jianlei Hao, Ligong Lu, Zhinan Yin, Yangzhe Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
apoptosis
pyroptosis
ferroptosis
immunosuppressive HCC TME
γδ T-cell imbalance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.845974/full

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